Breast Neoplasms ; etiology ; genetics ; pathology ; Chromosome Aberrations ; Comparative Genomic Hybridization ; Epithelial Cells ; pathology ; Female ; Fibroadenoma ; genetics ; Humans ; Loss of Heterozygosity ; Phyllodes Tumor ; etiology ; genetics ; pathology ; Stromal Cells ; pathology

The epidermal growth factor receptor ( EGFR)-small molecule tyrosine kinase inhibitor (TKI) has become the focus of clinical trials for first-line treatment of advanced non-small cell lung cancer ( NSCLC). Though TKI and concurrent chemotherapy show no advantage for survival, the use of TKI in combination with chemotherapy ( sequenced or maintenance) prolongs progression-free survival. In those patients with EGFR mutation, TKI as monotherapy in first-line setting has a significant effect on progression - free survival compared with chemotherapy. These data shows that EGFR mutation is effective predictor for TKI treatment.

Invasive fungal infection(IFI) is becoming increasingly important issue in pediatrics and pediatric intensive care unit. IFI often occurs in newborns and children with immune dysfunction. Candida and Aspergillus spp. are the most commonly isolated organisms. Early diagnosis can improve the prognosis of IFI. The 1,3-β-D-glucan(G)test,galatomannan antigen(GM)test and PCR test can aid earlier dignosis for IFI in high-risk children.

Aged ; Female ; Hemangioma, Cavernous ; complications ; Humans ; Kasabach-Merritt Syndrome ; complications ; Liver Neoplasms ; complications

This article analyses the chemical test results of several common repair mesh, and concludes the currently several common repair mesh are safe and reliable.
Prostheses and Implants ; Surgical Mesh ; standards

Excitatory Amino Acids ; secretion ; Humans ; Neurotransmitter Agents ; secretion ; Pain, Postoperative ; etiology ; metabolism ; prevention & control

Atherosclerosis ; Humans

No abstract available.
Humans ; Quality of Life* ; Self Care*

Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Infant ; Lung ; diagnostic imaging ; pathology ; Lung Diseases, Interstitial ; diagnostic imaging ; pathology ; Male ; Pediatrics ; Pulmonary Fibrosis ; diagnostic imaging ; pathology ; Radiation Dosage ; Radiographic Image Enhancement ; Tomography, X-Ray Computed

CD163 is one of transmembrane glycoproteins expressed only in activated monocyte-macrophage cell membrane, which acts as a marker of activated macrophages. In sepsis, CD163 activates the intracellular signal transduction pathways in macrophages,regulates TNF-α, IL-10 and IL-6 expression, have antiinflammatory and antioxidant effects in the inflammatory process. Soluble CD163 (sCD163) is a soluble form of CD163 ,which could play anti-inflammatory and immunoregulatory effects by inhibiting T cells proliferation and activation. Serum concentration of sCD163 may be highly increased when severe infection. Detection of serum sCD163 is helpful to diagnose sepsis,and to evaluate the prognosis of severe infection and sepsis.