Breast Neoplasms ; etiology ; genetics ; pathology ; Chromosome Aberrations ; Comparative Genomic Hybridization ; Epithelial Cells ; pathology ; Female ; Fibroadenoma ; genetics ; Humans ; Loss of Heterozygosity ; Phyllodes Tumor ; etiology ; genetics ; pathology ; Stromal Cells ; pathology

No abstract available.
Humans ; Quality of Life* ; Self Care*

BACKGROUND:Pathogenesis of endometriosis involves many factors that ultimately lead to the emergence of endometrial glands and stroma outside the uterine cavity. OBJECTIVE:To review the research progress in the theory of endometrial stem cel s, and to provide suggestions for the pathogenesis and treatment of endometriosis. METHODS:VIP database and PubMed database were retrieved for articles addressing endometriosis stem cel theory, including original research, experimental analysis, case analysis and review, published from January 2005 to October 2015. Keywords wereendometriosis, stem cel sin Chinese and English, respectively. After removal of repetitive articles, 48 articles were included for final analysis. RESULTS AND CONCLUSION:Endometrial stem/progenitor cel s may exist in the endometrium, and these cel s and bone marrow stem cel s are speculated to be involved in the occurrence of endometriosis. Therefore, treatment of endometriosis is targeted to endometrial stem/progenitor cel s and abnormal regulation on signal transduction pathway, which provides new insight into the mechanism of action and treatment of endometriosis.

This article analyses the chemical test results of several common repair mesh, and concludes the currently several common repair mesh are safe and reliable.
Prostheses and Implants ; Surgical Mesh ; standards

Atherosclerosis ; Humans

Excitatory Amino Acids ; secretion ; Humans ; Neurotransmitter Agents ; secretion ; Pain, Postoperative ; etiology ; metabolism ; prevention & control

Objective To establish a better and easier method for producing resveratrol and soybean isoflavone from polydatin and genistin by microbic metabolic enzyme. Methods The fungal strain Aspergillus niger S was fermented with solid medium. The enzyme isolated from Aspergillus niger S was purified by precipitation with ammonium sulfate and column chromatography with Q sepharose fast flow and superdex G200. The purified enzyme could be used to transform both resveratrol and soybean isoflavone. An analytical method for all the transformed products was established by the improved RP-HPLC. The HPLC separation was performed using a C18 250mm?4.6mm column and a gradient elution program. The eluent was acetonitrile/0.1% acetic acid in a flow rate of 1ml/min. The wavelength for ultraviolet detection was 280nm. Results The molecular weight of the enzyme isolated from Aspergillus niger S was about 165 kD, which was quite different from other reported glucosidases. The optimal temperature for this enzyme was 50℃, and the enzymatic activity decreased when the temperature dropped below 40℃ or elevated over 60℃. The optimal pH values were 5-10, and the enzyme would lose its activity if the pH was below 4. It was revealed by improved RP-HPLC that the products were polydatin and genistin at 27min and 39min, respectively, before enzyme treatment, while the transformed products at 45min and 64min after the enzyme treatment were resveratrol and genistein, respectively. Conclusions This purified enzyme isolated from Aspergillus niger S can transform both resveratrol and soybean isoflavone from low active form to high active form. It is a convenient and accurate method for the determination of resveratrol and soybean isoflavone. This method may be very useful in industry as well as clinical experimentation.

The antero-posterior chest rcentgenogram of mitral valve disease before and after valve prosthesis were presented for the preliminary evaluation of the surgical effects. The criteria included cardio-thoracic ratio, DPA/DHT X 100, diameter of Rt descending oranch of pulmonary artery, diameter of Rt upper pulmonary vein, total huar width, pulmonary hypertension, changes of pulmonary artery tributaries, K-B line, interlobar pleural thickening and pleural effusion. 15 cases of mitral valve dilation were selected randomly for control. The cardiopulmonary changes of the prosthetic group showed significant improvement 1/2 month postoperatively. the rate of improvement was rapid within the first 2 month and then slowed down gradually but improved steadily during the first year of convalescence. Statistical-ly most criteria showed P

Transforming growth factor-beta(TGF-?)signal pathway plays a critical role in the pathogenesis of diabetic nephropathy(DN)through inducing cell hypertrophy of glomerulus and renal tubule,accelerating the accumulation of extracellular matrix(ECM),and promoting glomerulosclerosis and tubulointerstitial fibrosis,etc.Smad was a newly discovered protein regulating the intracellular signal pathway of TGF-? super family.This article reviewed the studies on TGF-? signal pathway and its activating factors,roles and relevant treatments targeting the pathway in DN patients,hoping to provide references for the therapy and research of DN.

Objective:To study the influences of estrogen and progesteron on bone histomorphometry and renal expression of 1,25-dihydroxyvitamin D_3 receptor(VDR) mRNA in ovariectomized rats.Methods: Twenty-five adult female SD rats were equally randomized into 5 groups:sham-operation(Sham),ovariectomization(OVX),ovariectomization plus estrogen treatment(OVX+E),ovariectomization plus progesteron treatment(OVX+P) and ovariectomization plus both estrogen and progesteron(OVX+E+P) groups.All animals were killed to assess renal VDR mRNA expression by RT-PCR after 3.5 months feeding.Undecalcified proximal tibia was used to assess the bone histomorphometry with digitizing image analysis system.Results: OVX group,with weakened bone structure,had decreased cancellous bone and increased parameters of osteal formation and resorption compared with Sham,OVX+E and OVX+E+P groups(P