OBJECTIVE:To investigate the method for preparation and quality control of ornidazole oral membrane.METHODS:Ornidazole oral membrane was prepared with polyvinyl alcohol and sodium carboxymethylcellulose as its adju-vants;The content of ornidazole was determined by ultraviolet spectrophotometry at the wavelength of316nm.RESULTS:There was a good linear correlation within a range of6.0～18.0?g/ml(r=0.9997)of ornidazole concentration,the average recovery was100.19%(RSD=0.66%,n=5).CONCLUSION:The established technique is simple,and the content deter-mination is quick,precise and reliable.

Objective Evaluation of enema application of Yiyi-Fuzi-Baijiang powder combined with oral sulfasalazine enteric-coated tablets in treating ulcerative colitis. Methods The patients with ulcerative colitis were randomly divided into 2 groups, 42 cases in each group. The control group was treated with sulfasalazine, and the observation group with sulfasalazine and Yiyi-Fuzi-Baijiang powder. Both groups were treated for 4 weeks. ELISA method was used to detect the levels of IL-6, IL-8 and TNF-α. The changes of disease activity index (Sutherland DAI) were observed before and after treatment, and the clinical efficacy was evaluated. Results After treatment, the Sutherland DAI (3.89 ± 0.91 vs. 4.91 ± 1.08, t=3.082) in the observation group was significantly lower than that in the control group (P=0.042). The level of TNF-α (20.82 ± 4.31 ng/L vs. 26.51 ± 5.25 ng/L, t=3.602), IL-6 (31.73 ± 4.82 ng/L vs. 40.18 ± 5.63 ng/L, t=3.817), and IL-8 (35.39 ± 4.62 ng/L vs. 40.59 ± 5.35 ng/L, t=3.341) in the observation group were significantly lower than those in the control group (P<0.05). The total efficiency of observation group was 92.9% (39/42), and the control group was 73.8% (31/42). There was significant difference between the two groups (χ2=4.200, P=0.040). Conclusions The Yiyi-Fuzi-Baijiang powder combined with sulfasalazine could relieve the clinical symptoms of ulcerative colitis patients with spleen-kidney yang deficiency, and inhibition inflammatory response.

The paper elabrates the function of bibliographic management software in either managing literatures or writing papers, as well as the noted problems of college and university libraries carrying out bibliographic management software training. It also points out the importance of the software application in medical information literacy education.

AlM: To establish the frequency, associations and risk factors for age-related macular degeneration ( AMD ) in hospital population.
METHODS: ln this hospital based study, 589 subjects above 60 years of age were screened randomly for AMD. Participants underwent ocular evaluation and were interviewed for lifestyle variables and dietary intake of carotenoids by structured food frequency questionnaire. AMD was defined according to the international classifications and grading system.
RESULTS: Either form of AMD was detected in 48 participants. AMD was significant among diabetes, diabetic retinopathy, body mass index, heavy cigarette smokers and alcoholics ( P < 0. 05 ). Dietary lutein/zeaxanthin ( L/Z) and β-carotene intake were associated with the reduction in risk for AMD(P<0. 05).
CONCLUSlON: Higher dietary intake of carotenoids, especially L/Z, is associated with lower risk for AMD. Risk of AMD is prevalent among subjects with diabetes. Cessation of smoking and alcohol may reduce the risk of AMD in this population.

Planar cell polarity pathway regulates cell polarity and polarized cell movements.Recent studies in mouse models have found mutations in several genes in this pathway and specifically in the Vangl2 gene,which results in abnormalities in cardiac development,suggesting Vangl2 and this pathway play an important role in heart development.This review mainly elucidates the mechanisms regulated by the Vangl2 gene and PCP pathway during outflow tract development and the formation of the coronary vasculature.

Objective To observe the clinical curative effect of Bushen Tiaochong method on treating early unexplained recurrent spontaneous abortion (URSA). Methods 200 patients who conformed to the inclusion criteria were randomly and paralleled control study divided into two groups.The control group (routine tocolysis group,n =100 ),with 8 cases fell off. The experimental group (routine tocolysis group +traditional Chinese medicine group,n =100 ),with 10 cases fell off. Results After the treatment,the total efficiency of the control group was 70.65%,and the experimental group was 88.89%. The total efficiency of comparative difference was statistically significant (p<0.05 ). And compared the experimental group with the control group,the former group improved the level of human chorionic gonadotropin(HCG)in patients. Conclusion Bushen Tiaochong method with traditional Chinese medicine combined western medicine treatment can significantly improve the symptoms of URSA patients with threatened abortion. Compared with simple western medicine therapy,the former group has better curative effect on early unexplained recurrent spontaneous abortion.

National Cancer Institute initiated the project of building the cancer genome anatomy project in order to find a series of indices to retrieve information about genes,proteins and other biological markers related to cancers in 1996.At present,the project has been speeded up with the help of advances in the development of bioinformatics that could provide enormous biological information.Several bioinformations techniques that are commonly used include: Expressed Sequence Tags,Unigene,Serial Analysis of Gene Expression and Digital Differential Display.Each method has its own advantages,which together make up the bioinformatics technology.In this article,we reviewed the application of bioinformatics in cancer research and predict its trend.

Etiquette education is an essential part of modern nursing quality education.In order to improve the general quality of the nursing students by etiquette education,the nursing teachers can infiltrate the essence of etiquette education into education reform,by theory teaching,demonstration, portrayal training,scenario training,and so on.

OBJECTIVE:To discuss the disposal of essential oil in the preparation process of solid preparations containing Ligusticum chuanxiong and Angelica dahurica.METHODS:Based on pertinent literature in recent years,the disposal of essential oil in the preparation process of solid preparations containing Ligusticum chuanxiong and Angelica dahurica was discussed from aspects of chemical components,pharmacology and extraction process etc.RESULTS & CONCLUSION:It is necessary to combine research on preparation process with the pharmacological effect and pharmacodynamic action,and to formulate effective measures to control quality of the essential oil during the whole preparation process to facilitate a solution for the disposal of essential oil.

Background:With the increase in pace and pressure of modern life,the aging of population,the change in dietary pattern and the challenge of social psychological problems,the overall prevalence of chronic constipation is increasing in general population in recent decades. Aims:To investigate the prevalence and associated factors of chronic constipation in medical staff. Methods:A total of 1 000 medical staffs were enrolled at random in Shanghai Ren Ji Hospital for fulfilling a questionnaire on associated factors of chronic constipation. Diagnosis of chronic constipation met the Rome Ⅲ criteria. Chi-square test and Logistic regression model analysis were performed to screen the potential risk factors for chronic constipation. The statistically significant variables revealed by chi-square test were taken into the Logistic regression model. Results:Nine hundred and eighty-six medical staffs completed the questionnaire,of them 115 were diagnosed as chronic constipation with a prevalence of 11. 7% . Multivariate Logistic regression analysis revealed that reading/ playing cell phone when defecation,working pressure,anxiety,and depression were the risk factors,which might increase the prevalence of chronic constipation;while regular life style,regular diet,drinking water,and regular bowel movement were the protective factors,which might decrease the prevalence of chronic constipation. Conclusions:Chronic constipation is prevalent in medical staff in Shanghai. Psychological factors,dietary pattern and life style,etc. are considered to be implicated in the pathogenesis of chronic constipation. Favorable life style,dietary pattern,bowel habit and mental status are associated with the reduced risk of chronic constipation.