Objective:To explore the relationship between the latent classes of online emotion regulation among college students and the distribution difference of different types on variables such as gender,grade,ages of surfing the net and so on.Methods:Totally 421 college students were assessed with Online Emotion Regulation Questionnaire (OERQ).Latent class analysis was used to identify online emotion regulation classes,and then analyzed the distribution of latent classes among different genders,grades and ages of surfing the net.Results:Two latent classes of online emotion regulation were identified,including online emotion inhibiting/ignoring class (37.6％) and online emotion venting class (62.4％).The prevalence of online emotion venting class among girls (56.6％ vs.3.8％),sophomores (36.3％ vs.11.9％),juniors (23.4％ vs.3.1％),those with more than 36 months of surfing the net (31.6％ vs.18.8％) were significantly higher than the other of the respective kind.Whereas,the rate of inhibiting/ignoring class among boys (32％ vs.7.6％),freshmen (20％ vs.5％) were significantly higher.Conclusion:It suggests that online emotion regulation could be divided into two different latent classes and prevalence of each class is significantly different in different genders,grades,and ages of surfing the net.

Objective To explore the effect of treadmill training on expression of glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor (BDNF) after cerebral ischemia-reperfusion in rats. Methods 30 male Wistar rats were randomly divided into sham group, model group and treadmill training group, with 10 rats in each group. The latter 2 groups were modeled with middle cerebral artery occlusion for 2 hours and reperfusion. The treadmill training group underwent treadmill exercise on the 3rd day after modeling for 12 days. Neurological function was evaluated with modified Neurological Severity Scores (mNSS). The neuronal pathological change in ischemic cortex was observed with HE staining. The expressions of GFAP and BDNF in cortex were determined by Western blotting. Results Com-pared with the model group, the mNSS scores decreased in the treadmill training group (F=9.931, P<0.01), the pathological damage in the ischemia cortex significantly lessened, and the expressions of GFAP (t=6.73) and BDNF (t=3.78) increased (P<0.05). Conclusion Treadmill training may increase the expression of GFAP and BDNF after cerebral ischemia-reperfusion in rats, and promote the recovery of neurologi-cal function.

Objective To investigate the clinical efficacy of acupuncture in treating subhealth.Methods One hundred and fifty-four patients with subhealth were allocated, using a random number table, to observation and control groups, 77 cases each. The control group received basic treatment by diet, exercise, rest and rest and psychological intervention and the observation group, acupuncture therapy in addition. Subhealth scale subscores and the 36-Item Short-Form Health Survey (SF-36) subscore were recorded and blood biochemical indicators were measured in the two groups before and after treatment. the clinical therapeutic effects were compared between the two groups.Results The total efficacy rate was 96.1% in the observation group and 83.1% in the control group; there was a statistically significant difference between the two groups (P<0.05). There were statistically significant pre-/post-treatment differences in subhealth scale subscores in the two groups (P<0.05). After treatment, sleep, digestion, urination, positive emotion, ability and social relation subscores were higher, and fatigue, discomfort and negative emotion subscores were lower in the observation group than in the control group (both P<0.05). There were statistically significant pre-/post-treatment differences in blood biochemical indicators in the two groups (P<0.05). After treatment, blood uric acid (UA), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were significantly lower and high-density lipoprotein cholesterol (HDL-C) was significantly higher in the observation group than in the control group (both P<0.05). The 36-Item Short-Form Health Survey (SF-36) subscore were higher in thetwo groups after treatment than before treatment (P<0.05). After treatment, physiological function, role-physical, role-emotional, body pain and general health subscore were significantly higher in the observation group than in the control group (P<0.05).Conclusions Acupuncture helps to improve subhealth status in population, regulate blood biochemical indicators and enhance the clinical therapeutic effect to raise the quality of life in the patients.

Objective:To explore the correlation between fibrinogen levels and chemotherapy effect of platinum drugs in ovarian cancer patients. Methods:Totally 91 ovarian cancer patients and 95 patients with benign ovarian tumor were involved in our retrospec-tive study, and the associations between preoperative fibrinogen levels and clinic pathologic parameters in the patients were analyzed. Results:High fibrinogen levels were observed in 36.26％ (33/91) of the patients with ovarian cancer ( >4.0 g·L-1), which was significantly higher than that in the patients with benign tumor(P<0. 05). The high fibrinogen levels in ovarian cancer patients were associated with the higher FIGO stage and poor chemo-response, while were not associated with the patients' age, CA-125 levels and histological type and grade (P>0. 05). More importantly, no correlation was observed between high blood fibrinogen and CA-125 lev-els (P>0.05). Chemotherapy resistance was more in the patients with high fibrinogen levels than that in the other patients(P <0. 05). The OR value of high fibrinogen levels was 3. 571, 95％ CI was 1. 276-10. 000, which suggested high fibrinogen level is a dangerous factor for chemotherapy resistance. Conclusion:The study suggested that elevated fibrinogen level was a dangerous factor for chemotherapy response, which has a potential role in the poor prognosis of ovarian cancer patients independent of CA-125.

Ultrasound imaging is widely used in clinical daily diagnosis and treatment, and is considered to be a preferred examination in a variety of diseases. With the rapid development and continuous integration of computer technologies and related cross-field technologies, the novel ultrasound technologies have emerged, which greatly expand the application fields of ultrasound. From the clinical viewpoint, this article reviews several new ultrasound technologies and their application progress in recent years.

To prepare oroxylum indicum ( OLI) buccal tablets. Methods:The extract of oroxylum indicum as the main component, the buccal tablets were prepared using a wet granulation compression method. According to the results of single factor ex-periments, an orthogonal design was used to select the optimal formula based on the appearance, taste, disintegration time and friabili-ty. The average weight variation and average disintegration time were tested to evaluate the quality of three batches of the buccal tablets with the optimized formula. Results:The optimal formula was composed of 50%mannitol, 5%sucrose-stevioside (100∶1), 5% pep-permint oil and 35%PVP-K30-85% ethanol (6∶10). For the three batches of the buccal tablets with the optimized formula, the aver-age weight variation was (1. 83 ± 0. 29) % and the average disintegration time was(14. 7 ± 0. 6) min, which met the requirements of quality control on buccal tablets in Chinese pharmacopoeia. Conclusion:The optimal formula and process of OLI buccal tablets show fine reproducibility and stability.

The new curriculum reform brought forth under the context of a new round of knowledge transformation has endowed teaching process with new meanings. A new type of teacher-student realationship characteristized with equality, democracy and dialogue is the precondition of successful teaching under the context of new curriculum reform; Knowledge and meaning reconstruction by the way of presetting and generating is the main feature of teaching process; The development process consisting of knowledge and life of both teachers and students is the ideal goal of new curriculum reform.

Objective:To observe the clinical efficacy of traditional tuina plus modern rehabilitation in the treatment of lower limb extensor spasticity during stroke recovery.Methods:A total of 93 stroke patients who met the inclusion criteria were randomly divided into an observation group and a control group.Forty-four patients in the observation group were treated with traditional tuina plus modern rehabilitation,and 49 patients in the control group were treated with modern rehabilitation.The modified Ashworth scale (MAS),the Fugl-Meyer assessment scale (FMA) and the modified Barthel index (MBI) were used to evaluate the knee extensors state,lower limb motor function and activities of daily living (ADL) of the two groups.Results:After treatment,the overall efficacy of the observation group was better than that of the control group,and the difference was statistically significant (P＜0.05).After treatment,the MAS scores of both groups were significantly lower,FMA and MBI scores were significantly higher,and the differences were statistically significant in each group (P＜0.01).After treatment,the MAS score of the observation group was lower than that of the control group,and the difference between the groups was statistically significant (P＜0.01).The MBI score of the observation group was higher than that of the control group,and the difference between the two groups was statistically significant (P＜0.05).There were significant differences in the post-treatment changes in MAS,FMA and MBI scores between the two groups (all P＜0.05).Conclusion:Traditional tuina plus modern rehabilitation therapy can effectively alleviate or prevent lower limb extensor spasticity after stroke,and improve limb mobility and ADL.Hence,it is worthy of clinical promotion.

Amyotrpnic lateral sclerosis (ALS) is one of motor neuron diseases, which could result in the progressive muscular atrophy and paralysis. This article reviewed the recent researches for ALS treatment.

Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively optic nerve and spinal cord. NMO-IgG, an auto-antibody against aquaporin-4 (AQP4), identifies NMO as a disease entity separating from a severe variant of multiple sclerosis (MS). AQP4 is particularly abundant on the central nervous system, and is involves in regulation of water among of glial cells, and the blood and cerebrospinal fluid. NMO-IgG can target the AQP4 and initiate immune response leading to AQP4 protein loss in lesions, which is the key pathological mechanism of NMO.