Objective To explore the antagonistic effect of Schistosoma japonicum soluble adult worm antigen (SWA)and solu-ble egg antigen (SEA)in the mice with type 1 diabetes.Methods The 24 successful modeling type 1 diabetes mice were randomly divided into three groups (A,B,C group,n=8).SWA and SEA of Schistosoma japonicum were prepared.Mice in A group were immunized by abdominal subcutaneous multi-point injection SWA.Mice in B group were immunized by abdominal subcutaneous multi-point injection SEA.And mice models of C group were immunized by PBS instead of antigen through abdominal subcutaneous injection.The mice got immunization once a week,a total of four times.4 weeks later,the mice were sacrificed,and serum speci-mens were collected for the determination of serum levels of IL-4 and IFN-γby double-antibody sandwich ELISA,while pancreas tissues were collected and the pathological changes were observed.Results The serum IL-4 level of B group [(23.87 ±4.85)pg/mL]was higher than C group [(4.39 ± 0.56 )pg/mL],with significant differences (P < 0.01 ),while the serum IFN-γ level [(271.85±26.04)pg/mL]was lower than C group [(362.79 ±32.50)pg/mL],also with significant differences (P <0.01).The serum IL-4 and IFN-γof A group were (5.09±0.37)pg/mL and (379.56±34.47)pg/mL,which had no difference with C group (P >0.05).The islet structure of mice in B group was not intact,however,the lymphocytic infiltration in B group was less than C group,and there was no lymphocytic infiltration in pancreatic islets in B group.Compared with C group,the pancreas of mice in A group did not have significant changes,lymphocytes infiltration was still visible in islets.The number of residual islet cells de-creased,and visible minority islet structure was destroyed.Conclusion SEA of Schistosoma japonicum has certain antagonism effect on type 1 diabetes in experimental mice.Its mechanism may be the reduction of Th1 response and the enhancement of Th2 response through increasing IL-4 level and decreasing IFN-γlevel.

The interventional therapy of chemoembolization is the first management of choice in treating unresectable hepatic carcinomas but with some side effects including liver function damage and bone marrow restraints which may affect the patients'life expectancy and living quality in the long run.The advancement of the combination of interventional treatment with Chinese drugs in managing liver carcinomas is a special presentation by the auther for further recommondation.

Basic research in interventional radiology,including transcatheter artery perfusion especially,is progressing slowly due to lack of proper method.Microdialysis technique,a kind of accurate sampling technique in vivo,may help to solve the problem.Just as its name implies,microdialysis means tiny dialysis with advantages of authenticity,exactness and less error.Furthermore it has been applied widely and should be received with great attention and popularity.

The articles concerning intensive effect and progress of interventional therapy for hepatocellular carcinoma (HCC) recurrence were comprehensively reviewed. Along with unceasing abundance of all interventional methods (including transcatheter arterial chemoemblization (TACE),percutaneous dehydrated ethanol injection,radio frequency ablation,percutaneous microwave therapy,argon-helium cryoablation,high-intensity focused ultrasound and radionuclide interventional therapy,etc),combined interven-tional therapies mainly TACE were increasingly appreciated in postoperative HCC recurrence,but still have to be further standardized. With further emerging and maturing of new technologies,such as antiangiogenesis,gene therapy and targeted therapy on HCC metastatic and recurrence specific cycle; the effect of combined therapy will be further promoted. Interventional therapy will play an important role in the prevention and treatment of postoperative HCC recurrence in the foreseen furture.

Objective:To study the cognitive features of text anxiety. Methods: The cognitive features of text anxiety were explored by exploratory factor analysis and confirmatory factor analysis on the basis of interview,questionnaire surveying and criterion.Results:There were 6 cognitive factors leading to test anxiety: self-test, worrying, magnifying conclusion, resistance, preparing, self-efficacy.Conclusion: The 6 factors of cognition about text are related to text anxiety

Objective: To explore the differences between the internal social adaptation and external social behaviors of freshmen. Methods: Make a survey of 198 freshmen on the internal adaptation and external by General Well-Being Schedule and Undergraduate Social Adaptation Questionnaires. Results:Freshmen' social adaptation mainly involves three factors: interpersonal communication, the state of campus life and performance of studies. The Cronbach alpha of 3 factors were 0.82, 0.87 and 0.90,and the re-test reliability was r=0.73 (P

The advances in domestic knowledge service ability were outlined from the aspects of its concept, constitutional elements, construction and assessment based on an analysis of papers on knowledge service ability covered in CNKI.The related problemsand certain aspects that need to be further studied were pointed out.

Objective To observe the effects of different environmental intervention on the learning-memory ability and choline acetyltransferase (ChAT) expression around the infarct in rats with unilateral local cerebral infarction.Methods SD rats were subjected to electric coagulation of MCA and then were assigned randomly to ①control group(5 in each group housed in a standard cage),②learn training group(housed in a maze cage),③enriched environment group(housed in a enriched environment cage).24 days later,rats were trained by water maze,and then killed for immunohistochemistry staining.The expression of ChAT in peri-ischemic cortex was examined.Results The escape latency of rats in enriched environment was the shortest((26.9 ± 4.8)s),and the times striding over the platform was the most(6.1 ±1.1),longer (33.6 ± 5.1)s and less (4.8 ± 1.2)in the learn training group,the longest ((41.4 ± 6.4) s) and least (3.3 ± 0.9) in the control group.The positive cells of ChAT in enriched environment group (40.3 ± 8.4) were higher than those in learn training group (35.6 ± 7.8) and those in control group (25.4 ± 6.5).Conclusion Enriched environment after MCAO could promote the learning-memory ability and up-regulate the expression of ChAT in the peri-ischemic regions.

Objective To analyze the epidemiological status and drug resistance to common antibiotics of non-fermentative bacilli in our hospital,in order to provide the guideline for reasonable use of antibiotics.Methods A total of 825 strains of non-fermentative bacilli from various clinical specimen were analyzed retrospectively.Results A total of 825 strains of non repetitive non-fermentative bacilli were isolated.The first of the three vibrionaceae were 301 strains Pseudomonas Aeruginosa accounted for 36.48％,279 strains of Acinetobacter baumannii accounted for 33.81％,a few malt raise form afterbirth fungus 245 plants accounted for 26.69％.Strains isolated from phlegm,urine and pharynx swab were 580(70.30％),105(12.73％) and 68(8.24％) respectively.Infections with non-fermentative bacilli occurred in the department of respiratory medicine,surgery and ICU were 290 (35.15％),212 (25.70％) and 125 (15.03％) respectively.The susceptibility results of antibiotics showed that the resistant rate of bactrim,Cefotaxime,and Ceftriaxone was beyond 85.00％ with Pseudomonas Aeruginosa.Acinetobacter baumannii strains of Amikacin,Aztreonam,cefotaxime resistance rate was beyond 36.00％,while beyond 95.00％strains of Pseudomonas Aeruginosa and Acinetobacter baumannii were sensitive with Imipenem and Meropenem.The resistant rate of Cefepime,Imipene,m,Meropenem,Cefotaxim-c,Aztreonam was beyond 100.00％ with Stenotrophomonas maltophilia,while which were sensitive with Minocycline.Conclusion Non-fermentative Bacilli hospital infection is the main pathogenic bacteria,and existence multiple drug resistance to antimicrobial agents.

Objective: To investigate the safety and feasibility of Laparoscopic left hepatic lobe resection in the treatment of bile duct stones. Methods: Eighty cases in our hospital with bile duct stones for left hepatic lobectomy were randomly divided into control group and experimental group. The control group was received open left hepatic lobectomy. The experimental group was received laparoscopic left hepatic lobectomy. The operative time, incision length, blood loss, hospital stay, hospital costs and incidence of postoperative complications were compared of two groups. Results: The incision length and length of hospital stay of experimental group was significantly shorter than control group. The difference was statistically significant (t=4.46, t=5.38; P<0.05). While operative time, blood loss, hospital costs and postoperative complication rate of two groups showed no significant difference (t=0.32, t=0.73, t=0.37; x2=0.47; P>0.05). Conclusion:Laparoscopic left hepatic lobe resection is safe and feasible in the treatment of bile duct stones with the advantage of less trauma and quicker recovery. It’s worthy of clinical widely used.