Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

目的观察急性心肌梗死患者早期康复护理的远期效果。方法40例老年急性心肌梗死患者随机分为实验组20例(早期康复组)和对照组20例(常规治疗组),前者接受2周的康复护理,后者接受3周的康复护理。对两组患者进行为期18个月的随访,观察其心功能、活动情况,及心绞痛和再梗死的发生率。结果两组患者的心功能无明显差异,但实验组患者心绞痛的次数和再梗死的发生率低于对照组(P<0.05)。结论对急性心肌梗死患者进行早期康复是安全、可行的,可改善心功能和降低再梗死的发生率,减少并发症的发生。

Recently,targeted therapy plays an important role in the treatment of non-small cell lung cancer.Crizotinib,the first generation of anaplastic lymphoma kinase( ALK) tyrosine kinase inhibitor,has been ap-proved for the treatment of ALK-rearranged NSCLC in the US since 2011.However,the crizotinib therapy is ef-fective only in the early stage of treatment.After a long time treatment,therapy resistance will follow because of the emerging second mutation of the tumor cell.In recent years,as the second generation of anaplastic lymphoma kinase tyrosine kinase inhibitor, alectinib has been approved in Japan for the treatment of ALK -rearranged NSCLC patients.Thus,research progress of Alectinib for NSCLC therapy is summarized in this article.

Chronic refractory autoimmune thrombocytopenia (C/RITP) comprises complex and heterogeneous pathogenesis.Beyond the classic immune disorders such as platelet autoantibodies and cellular immune imbalance,other important considerations that can cause acquired C/RITP include infection,drug,vaccines,autoimmune diseases,tumor,or platelet function disorder.In addition,advances in the molecular mechanism and genetic correlations of C/RITP for children are also discussed.

Purpose To detect the expression of Nek2, Plk1 and Cdk1 in gastric carcinoma and to explore their correlation with clini-copathological factors. Methods We used immunohistochemistry to detect the protein expression of Nek2, Plk1 and Cdk1 in 80 cases of gastric carcinoma. Results The positive rates of Nek2, Plk1 and Cdk1 expressions in 80 cases of gastric carcinoma were 64%, 79% and 85% respectively. While the positive rates of Nek2, Plk1 and Cdk1 expressions in 20 cases normal gastric tissue were 15%, 10% and 20% respectively,with statistical significance (P<0. 01). There were significant associations between Nek2 expression and differentiation of gastric cancer, invasion depth, lymph node metastasis and TNM stage (P<0. 05). There were no significant associa-tions between Nek2 expression and age, gender and tumor size (P>0. 05). The expression of Plk1 and Cdk1 had a correlation with tumor size, differentiation of gastric cancer, invasion depth, lymph node metastasis and TNM stage (P<0. 05). There were no signifi-cant associations between Plk1 and Cdk1 expressions and age and tumor size (P>0. 05). There were significant associations between Nek2 and Plk1, Plk1 and Cdk1, Nek2 and Cdk1 expression (P <0. 01). Conclusions Abnormal expression of Nek2, Plk1 and Cdk1 might be one of the mechanisms of tumorigenesis, especially of abnormal tumour proliferation. They may represent new potential targets for therapeutic intervention.

Objective To observe the clinical efficacy of acupuncture plus Chinese herbal medicine in treating nonalcoholic fatty liver disease.Method Totally 132 patients with nonalcoholic fatty liver disease were randomized into a treatment group of 67 cases and a control group of 65 cases. The treatment group was intervened by acupuncture plus Chinese herbal medicine, while the control group was by oral administration of Silibinin capsules. Liver function, blood lipid level, and type-B ultrasonic check were observed before and after intervention, and the clinical efficacies were compared.Result ALT and AST contents were changed significantly after intervention in both groups (P<0.01). There were no significant differences in comparing ALT and AST contents between the two groups after intervention (P>0.05). After intervention, TC, HDL, TG, and LDL contents were significantly changed in both groups (P<0.01,P<0.05). There were no significant differences in comparing TC, HDL, TG, and LDL contents between the two groups after intervention (P>0.05). The total effective rate was 95.5% in the treatment group versus 90.8% in the control group, and the difference was statistically insignificant (P>0.05).Conclusion Acupuncture plus herbal medication is an effective approach in treating nonalcoholic fatty liver disease, as it can improve liver function and down-regulate lipid level.

BACKGROUND:Kirschner wire fixation is the most extensive method to repair metacarpal and phalangeal fractures,but it has some disadvantages such as poor stability and many complications.Present studies suggest that surface rigidity,stability of fracture fragments and fracture healing of mini-plate were better than other fixation methods.Based on anatomical reduction,mini-plate fixation can firmly fix the bone,does not destroy articular surface,so it can restore hand function to the maximum extent.OBJECTIVE:To compare and analyze the therapeutic effects and adverse reactions of Kirschner wire and mini-plate fixation for repair of metacarpal and phalangeal fractures.METHODS:A total of 76 patients with metacarpal and phalangeal fractures,who accepted surgical treatment in Department of Orthopedics,Yixing No.2 People's Hospital from January 2011 to January 2014,were selected.Patients were randomly divided into observation group and control group,with 38 cases in each group.The patients in the observation group (46 places) were treated by mini-plate fixation,while those in the control group (50 places) were fixed with Kirschner wire.Hand function was evaluated after treatment.Healing and complications were compared in both groups.RESULTS AND CONCLUSION:The excelent and good rate in the observation group was 91％(42/46),and 68％(34/50) in the control group,and the significant differences between the two groups were detected (P＜0.05).Total active flexion degree,length of hospital stay and healing time were respectively (147.2±89.6)°,(5.1±2.1) days and (51.4±18.3) days in the observation group,and (132.4±35.3)°,(6.9±2.4) days and (65.5±23.8) days in the control group.Length of hospital stay and healing time were shorter,but total active flexion was greater in theobservation group than in the control group (P＜0.05).Incidence of infection and delayed healing of bone were significantly lower in the observation group than in the control group (P＜0.05).Results suggest that compared with the Kirschner wire,mini-plate fixation for metacarpal and phalangeal fractures can obviously improve hand function,shorten length of hospital stay and healing time.It is safe and reliable,and is one of good clinical treatment options.

Objective: To evaluate the curative effect of auricular point sticking therapy on vertebral artery type of cervical spondylosis. Methods: With the single-blind randomized controlled trial design, the treatment group of 42 cases was treated by auricular point sticking therapy and the control group of 38 cases was treated with herbal medication. Fifteen days made up a treatment course, and the total treatment period should be no more than 2 course of treatment. Results and Conclusion: The total effective rate was 97.6% in treatment group and 73.7% in control group; there was a statistically significant difference between two groups, and the treatment group is marked superior to control group.

Objective To investigate clinical efficacy of the CT guided mixture Danshen injection into the periganglionic space in the treatment of lumbocrural pain.Methods Mixture Danshen infiltrations were performed in 63 patients with lumbocrural pain under CT guidance.Scores of VAS were compared at 3 and 6 months after the therapeutic procedure with evaluation of the efficacy.Results Significant pain reduction was observed in 51 patients (51/63,80.95%),with the score of VAS 7.60± 2.00 (before therapy) dropping to 3.85 ± 1.60 (after 1 month) and 4.05± 1.70 (after 6 month).Differences of VAS scores before and after the therapy were statistically significant.Differences between one-month and three-month follow-up were not statistically significant.Conclusion Mixture Danshen injection around the spinal nerve roots under CT guidance is safe and useful in the treatment of lumbocrural pain.

Objective Anovel index based on frequency-domain analysis of heart rate variability (HRV) was tested on patients with reduced left ventricular systolic function.This index,namely VHFI,was defined as the very high frequency (VHF) component of the power spectrum normalized to represent its relative value in proportion to the total power minus the very low frequency component.Methods Patients (n=130) were divided into a study group,consisting 66 patients with decreased left ventricular systolic function,and a control group,consisting 64 patients with normal heart structure and function and without severe coronary artery stenosis (＜50%).Results VHFI in the study group was significantly higher than that in the control group (19.17±13.35 vs 11.37±10.77,P＜0.001).Cardiac events occurred in 18 patients during follow-up (33.34±3.26 months).Defining the positive test as VHFI =15 and negative test as VHFI ＜15,achieved a sensitivity of 57.58% and a specificity of 78.13% for predicting decreased left ventricular systolic function,and achieved a sensitivity of 66.67% and a specificity of 64.29% for predicting cardiac events.Univariate Cox regression analysis showed that positive VHFI test was an independent variable in predictive cardiac events.Conclusions The results suggest that VHFI is a useful tool for quick evaluation of left ventricular systolic function and prediction of prognosis.