目的观察急性心肌梗死患者早期康复护理的远期效果。方法40例老年急性心肌梗死患者随机分为实验组20例(早期康复组)和对照组20例(常规治疗组),前者接受2周的康复护理,后者接受3周的康复护理。对两组患者进行为期18个月的随访,观察其心功能、活动情况,及心绞痛和再梗死的发生率。结果两组患者的心功能无明显差异,但实验组患者心绞痛的次数和再梗死的发生率低于对照组(P<0.05)。结论对急性心肌梗死患者进行早期康复是安全、可行的,可改善心功能和降低再梗死的发生率,减少并发症的发生。

Objective To study the reasons why PLoS One has set off an upsurge in China especially in hospitals, the academic level of papers published in PLoS One, and how to correctly judge the SCI-covered papers published by hospitals.Methods Papers published in PLoS One by hospitals in China were retrieved.The number of papers published in PLoS One by hospitals in China, the institutions that published the papers in PLoS One, and the num-ber of fund-supported papers were analyzed.Results A total of 9739 papers were published in PLoS One by hospitals in China from 2007 to October 2015, with an average cited frequency of 5.29.The majority of authors who published the papers were from affiliated hospitals of scientific research institutions and teaching hospitals of colleges and uni-versities.Of the 9739 papers, 87.78%were supported by funds from different foundations.Conclusion Nothing is strike about the academic level of papers published in PLoS One by hospitals in China with their average cited fre-quency lower than that (8.14) in our country.The SCI-covered papers published by hospitals should not be con-sidered as the only criterion in assessing the performances of staff in hospitals.

MicroRNA (miRNA) is a kind of small non-protein coding RNA and can negatively regulate the expression of target genes at the transcriptional level. In tumors miRNA can act as oncogenes and tumor suppressor genes, and its deregulation in tumors may be a possible reason for tumor progression. Several studies have established the potential usefulness of miRNA as therapeutic targets for tumor metastasis.

After the connotation of collaborative innovation service was described, the difficulties for libraries to carry out collaborative innovation service were analyzed, including the unbalanced distribution of benefits, difference in its understanding , difficulties for theleading libraryto play its role, and the approaches were put forward for libraries to implement their collaborative innovation service in libraries.

Congenital long QT syndrome ( LQTS) is a cardiac ion channel dysfunction, leading to prolonged myocardial repolarization time. It is characterized by the typical ECG QT interval prolongation and torsades de pointes. It shows clinical recurrence of cardiogenic syncope and even lead to sudden death. Molecular genetic studies have revealed a total of 12 forms of congenital LQTS caused by mutations in genes of the potassium, sodium and calcium channels or membrane adapter located on chromosomes 3, 4, 7, 11, 12, 17, 20 and 21. This review summarized the studies of the pathogenesis of LQTS and gene-related treatments.

Objective To investigate the regularity and characteristic of adverse drug reaction (ADR).Method 987 ADR cases collected in our hospital from 2005 to2010 were analysed statistically.Results Numbers of ADR reports increased quickly.The incidence of new and severe ADR increased every year.Numbers of ADR reports written by nurses and pharmacists increased every year.The incidence of ADR in female was higher than in male.Antimicrobials showed the highest proportion (76.46％) among all kinds of drugs which were involved in these ADR cases.Among all antimicrobials,penicilins which advanced cephalosporins and quinolones showed the highest proportion.83.49％ which were largest were caused by intravenous administration.Main clinical manifestation were lesion of skin and its appendants (44.66％).Conclusion Publicity and training of ADR knowledge,ADR monitoring and rational drug use should be strengthened in order to use drug safely.

Neutrophil genatinase-association lipocalin(NGAL)is a kind of lipocalin of binding proteins that seems to be a popular topic studied much recently,which at first was considered as endogenous bacteriostatic agent.It is bound up with the occurrence,development and prognosis of many kidney diseases.Therefore,it can provide new idea and method on clinical diagnosis and treatment by further study on expression and significance of NGAL in kidney diseases.

Depressive disorders are very common in older people.Most of the patients suffered from depressive disorders seek help from non-mental health professional in general hospitals.To help physicians in general hospitals to recognize and treat depressive disorders in the elderly,a case report on unrelieved chest pain after coronary artery stents is presented in this paper,and then clinical manifestation, diagnostic criteria, clinical assessment, principles for antidepressants and psychotherapies to alleviate depressive symptoms are introduced.

Pancreatic cancer is one of the most malignant gastrointestinal tumors,characterized by a poor prognosis,absence of specific clinical symptoms and signs,prone to metastases and lack of response to conventional therapy.1 year survival rate of this disease increased to about 20 ％ by gemcitabine,but the morbidity and mortality rates are still higher and higher in the whole worldwide.DNA methylation is one of the mechanisms of epigenetics which is the study of heritable changes in gene expression that are not coded in the DNA sequence itself.It seems that DNA methylation indeed plays an important role in the development and progression of pancreatic cancer.

Newborns,especially premature newborns,because of immature of immune function,have high incidence of sepsis.Today sepsis is still an important cause of neonatal death and poor prognosis.Unfortunately,clinical signs of sepsis are non-specific,so early diagnosis and treatment of the newborn infant with suspected sepsis are essential to prevent severe complications.Blood culture is the gold standard for diagnosis of sepsis,but the positive rote is low.Indicators in diagnosis of sepsis included acute phase reaction proteins,cytokines,cell surface antigen and bacterial DNA testing.This article compares and analyzes the indicators in diagnosis of neonatal sepsis.