Introduction: Gout is one of the most common inflammatory arthritis in Malaysia. It is due to persistent hyperuricemia that leads to the formation and deposition of intra- and periarticular monosodium urate crystals either due to excessive production or insufficient excretion of uric acid. Incidence and prevalence of gout is increasing worldwide, with a higher rate among men compared to women. Malay is the largest ethnic group in Malaysia, followed by Chinese and Indian. SLC2A9 is a renal urate transporter that controls renal uric acid excretion and genetic variants in SLC2A9 are associated with the risk of gout in several populations. This study aimed to test if the SLC2A9 variant (R265H, rs3733591) is also associated with gout among Malays in Malaysia. Methodology: A total of 89 patients with gouty arthritis and 100 normal subjects who consented and were recruited in this study. The serum urate and creatinine were measured. The SNP genotyping was performed using PCR-RFLP method for rs3733591 and BST 1236 was used as a restriction enzyme to cut the targeted amplicons. Result: SLC2A9 variant was associated with gout, p-value of 0.007, OR=4.713 [95%CI 1.530-14.513], however this association was not significant after adjustment for age and gender with p=0.465 (OR=1.950; 95%CI[0.325-11.718]). Conclusion: Our data suggest that the genetic variant of SLC2A9 may contribute to the susceptibility of gout among Malays in Malaysia.

To investigate the effects of comprehensive and integrated therapy on the recovery of facial nerve function,60 patients with post-stroke facial nerve injury were divided into two groups:Group A (control group) was administered a simple conventional medication,and Group B underwent acupuncture by total considered therapy and was administered a simple conventional medication.Thirty patients were enrolled in each group.The Portmann modified clinical symptom score,intracranial hemodynamics,and electrophysiological parameters were analyzed before and after treatment.Thirty days later,the clinical symptom score in Group B increased significantly compared with that in the control group ( Group B,17.0 ±2.5 ; Group A,13.0 ±2.0; P ＜0.01 ).Group B showed significant improvements in middle cerebral artery blood flow [ Group B,(90 ± 17 ) cm/s; Group A,( 52 ± 15 ) cm/s ; P ＜ 0.01 ],facial nerve conductivity [Group B,latency of the ipsilateral orbicularis muscle,(3.35 ± 0.67) ms; Group A (3.95 ±0.58) ms;P ＜ 0.01 ].These results indicate that the total considered therapy improved the recovery of post-stroke facial nerve function and that this improvement was related to the increase in intracranial blood supply.

Objective To observe the intrapartum analgesic effect of Doula GT-4a pulse acting working station and the influence of it on labor and mother-to-child. Methods The observation group use intrapartum analgesia of 98 primigravida,and the control group was other 98 primigravida without intrapartum analgesia in the same delivery period. Two groups of gravidas were delivering by a high qualification of midwife while your cervix expand for 2 ～3cm. The observation group was given with GT-4a pulse acting working station. Results The analgesia VAS scores of the observation group,significantly different with that of the control group:The first stage of labor active period accelerated significantly,the second stage of labor was shortened. The cesarean section rate,the vaginal birth rate and the neonatal mild choking rate significantly declined compared with the control group. Though there were no statistical differences between two groups with the third stage of labor, postpartum hemorrhage, and neonatal severe choking rate.Conclusion The andlgesie effect of doula combined with GT-4 pulse theraphy for labor was good. It reduced cesarean section rate, improved maternity quality and had no adverse effects.

Medical students participating in chnieal medical early is one of the good ways to cultivate students'all-around qualities From freshman year medical students begin to enter chnical medical service system and make clinical practice in spare time,They are also trained to link theory with practice to caltivate clinical thinking ability,strengthen its humanistic care idea and doctor-patient communication ability so that medical students will know the sacred profession of being adatov and from the idea of sewing patients work of the sacred doctor,set up'professional service to patients'concept.

Objective To study the non-drug treatment factors which affecting the control rate of hypertension in the elderly. Methods A questionnaire survey was made in total 260 cases 60～83 years old hypertensive patients in Beijing Normal University. Results Among the hypertension patients, who under 70 years old ,female, nonsmoker and those with stage 1 hypertension, a short duration of hypertension and non-diabetes-hypertension have higher control rate (P<0.05). Conclusions Actively intervening plan for the risk factors and rationally utilizing the non-drug treatment in the people greatly improve the control rate of hypertension.

AIM: To determine the effects of anisodamine (Ani) administered intraperitoneally on the gastric mucosal lesion induced by reserpine.METHODS:In reserpine-treated rats, gastric mucosal lesion, gastric acid secretion, gastric barrier mucus secretion, gastric contraction, gastric mucosal blood flow (GMBF), gastric mucosal nitric oxide synthase (NOS) activity and nitric oxide (NO) content were examined.RESULTS:Ani in doses of 1,5 and 10 mg/kg significantly inhibited the formation of gastric lesions induced by reserpine, with the suppressive rate of 60.0%, 66.7% and 76.6%, respectively. Ani (10 mg/kg) significantly inhibited the secretion of gastric acid, but had no effect on the volume of gastric juice. Ani (10 mg/kg) significantly prompted the secretion of gastric barrier mucus. Our findings also showed that Ani (10 mg/kg) significantly suppressed the frequency and amplitude of gastric contraction. Ani (10 mg/kg) significantly prompted GMBF. In reserpine treated rats, gastric mucosal NOS activity and NO content were decreased and Ani (10 mg/kg) could inhibit the decrease in NOS activity and NO content.CONCLUSIONS:The protective effect of Ani may results in part from inhibiting gastric acid secretion, prompting gastric barrier mucus secretion, suppressing gastric contraction and improving GMBF. NO seems to play an important mediator role in the Ani protective mechanisms.

Colorectal Neoplasms ; diagnosis ; prevention & control ; rehabilitation ; therapy ; Combined Modality Therapy ; Duty to Recontact ; Humans ; Neoadjuvant Therapy ; Quality Control

The mortality cases caused by influenza virus are offen associated with the secondary bacterial infection, Streptococcus pneumoniae infection in particularly. The mechanisms underlying the interaction between the virus and the bacteria are unclear at present. The damage of normal protective epithelial layer and changes in airway function caused by influenza virus provides increased numbers of attachment sites and culture spaces for the bacteria. The effect of influenza on immune system is a further opportunity for subsequent bacterial infection. The synergistic effect between influenza virus and Streptococcus pneumoniae might not be unidirectional. The bacteria caused the secondary infection could enhance the pathogenicity of the virus. The bacterium-derived proteases could cleave hemagglutinin to its active components that are required for infectivity of the virus. The effect of the bacteria on the virus could enhance the lethality of the primary viral disease, which can explain why antibiotic therapy was less successful to treat the influenza patient with subsequent bacteria infection. Effective strategies to prevent and treat the severe diseases could be suggested based on the knowledge of interaction between virus and bacteria.

Objective To investigate the relationship between carotid artery intima-media thickness(IMT) and blood pressure(BP) as well as QT dispersion in 18 - 35 young people. Methods Body mass index (BMI) and BP of 107 people in 18 - 35 years of age were measured, the carotid artery was also detected by 2-dimensional and color Doppler ultrasound. According to BMI,a]I candidates were divided into group A(norrnal BMI) and group B(obesity), then the relationship between IMT and BP, QT dispersion were analyzed. Results Compared with group A,BP,IMT,QT dispersion in group B were increased, there was significant diference between the two group (P <0.05). Relationship was positive correlative between IMT and systolic BP(LIMT: r=0.224, P=0.021;RIMT:r=0.193,P=0.047) ,but negative correlative between IMT and diastolic BP(LIMT: r=0.123, P=0.210; RIMT: r=0.138, P=0.159). The risk estimate of abnormal IMT was higher when QT dispersion >50 ms than that ≤50 ms(OR=6.223, P<0.05). Conclusions The systolic BP is positive correlative with IMT of carotid artery at age 18-35,increasing QT dispersion is a high risk factor of abnormal IMT. IMT should be detected when QT dispersion >50 ms and systolic BP >120 mm Hg.