The distribution of 30 HLA-DRB1 alleles in 85 individuals and 10 HLA-DQB1 alleles in 91 muong populations respectively was studied and compared with those of 8 other Asian populations, including kinh population (103 people), a major ethnic of Viet Nam. The difference was observed in some HLA alleles between the muong and kinh ethnics, the most striking presented in HLA-DQ1*0502 allele (frequency of 48%) in the muongs and in DRB1*1202 in the kinhs. In term of genetic distance, our data support a close relationship between muong, Buyi and Dai Lue, another Southern Chinese ethnic group. conversely, these three populations are distant from North Chinese. This was discussed basing on the ethnic relation.
HLA-DRB1 antigen ; Vietnam ; Alleles ; Ethnic Groups

Like every biological body, the cells under 4 phases: generation growth, development and end. There are 2 ways of the end of cell: necrosis death or apoptosis. The apoptosis related with some diseases that these disorders may be etiological mechanism of diseases. Today, the etiological mechenism of apoptosis has been discovered. The ways of inhibition or stimulation of this process in diseases of increased apoptosis are being studied.
Apoptosis ; cells

This study introduced about recent advances of resistance to HIV, problem of HIV to receptor and co-receptor and The action between HIV and HIV infected body.
HIV ; HIV Infections

The Nobel Prize in biomedicine is given for Guenter Blobel in Karolita Sweden in 12th December 1999. He discovered the “signs in protein which directs the transport and migration of its in the cell”. The value of theme becomes more efficient when many signal procedures in protein synthesis, especially adhesive molecules that common the relation of cell with anothers in live body during their action. Without these molecules on there is unnormal for them will lead to pathological conditions. However, the biological technology of genetransfer has opened many opportunities of treatment, today.
Nobel Prize ; biology ; medicine

Stockholm Carolinska Institute promulgated Nobel prize for three American Scientists on October 12, 1998. Murad is clinical physician, he determined a agent of monooxyt nitric as chemical mediator of circulation system. Its important opened new study way. Study on NO function not only restrict in circulation sector but also extend in nervous system and immune system
Nitric Oxide ; Nobel Prize

The Nobel prize for the medicine in 2000 was dedicated to Arvid, Carlsson (Swiden), Paul Greengard and Eric Kandel (Ameria) by Swiden Royal academic institute. Their invent plays a vital role in discovering the normal functions of the brain and how the disorder in the sign transmission system can cause the nervous and psychological diseases. From these, researchers have prepared the new drugs including prozac as well as elucidated the cause and treatment of Parkinson, Schizophrenia and cerebral and nervous system disorders.
Nobel Prize ; medicine

The Nobel Prize in Bio-Medicine 2001 was handed to 3 researchers (2 English and 1 American) by the Swiden Academic Institute Korolinska for their invent on the “Major regulotor in the cycle of cell division”.
Nobel Prize ; medicine ; biology

Biomedical is biological application for human in pathological condition. More specifically, the biology applied for analysis of samples from blood or other biological products to contribute to the diagnosis as well as monitoring and treatment
Research, Biomedical

With the progress of molecular biology and the mapping of total human genome, treatment of monogene diseases by the method of gene engineering was possible as preliminary achieved success, but there were still unsolved problems. The most difficult problem had been that the insert of a healthy gene into a modified cell could product a deficit protein, but what is the mechanism of controlling and regulating its activity because homeostatic equilibrium is an important principle of a living body. This principle will not be assured when a gene activated without an equilibrium mechanism. When the new gene begins to activate, an other condition will be occurred, for instance an access of the previously deficit protein, i.e. an artificial cancer
Genes ; Therapeutics ; Disease

During study in HIV/AIDS, US researchers of National Institute of Allergy and Infectious Diseases found that sometime gene mutations in immune-competent cells could help body have better resistance to cardiovascular diseases. These mutations are in some receptors of chemokines in membrane of immune cells. Results of experimental trial in mouse had gene mutation in receptor CX3CR1 showed that this mutant could make better resistance to high-risk factors and genetic factors in pathogenesis of cardiovascular diseases. This finding provided a new way to study drugs that have effects right on chemokine receptor CX3CR1 of high-risk patients with atherosclerosis
Cardiovascular Diseases ; Chemokines ; Mutation