Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

Objective To promote students health knowledge and behavior and to create work that would provide the basis for evaluating the health promoting school. Method In 102 of the health promoting schools, using cluster random sampling method, in each applied school last digit survey date was used as a random number, selected classes were investigated about the infectious disease, chronic disease, vaccination, emergencies and other items. The subjects of the investigation were totally 5 368 people, 2 673 girls, and 2 695 boys, including primary school students 2 848 (rural students 1 272, 1 576 urban), middle school students 2 520 (rural students 1 127, 1 393 urban). All the 5 368 questionnaires were returned, 5 366 were valid. Chi-square test was used to evaluate health knowledge awareness and behavior formation rate, P<0.05 was regarded as having statistical significance. Result Overall, the awareness rate of knowledge (84.5%) and behavior formation rate (76.5%) of girls were higher than those of boys (83.4%, 75.1%) (χ2=26.17, 13.23, P<0.05). The awareness rate of knowledge of primary school girls (83.1%) and their behavior formation rate (76.9%) were also higher than those of primary school boys (81.9%, 74.5%) (χ2=13.70, 21.58, P<0.05) city primary school students; knowledge rate (85%) and behavior formation rate (77.6%) of urban students were higher than those of rural students (80.2%, 74.1%) (χ2=226.99, 49.28, P<0.05). The awareness rate of knowledge of middle school girls (86.1%) was higher than that of middle school boys (85.1%) (χ2=9.73, P<0.05);awareness rate of knowledge (85.8%) of middle school urban students was higher than that of rural students (84.3%) (χ2=22.37, P<0.05). The awareness rate of silver and bronze school knowledge (84.0%, 84.0%) was higher than that of gold (80.6%) (χ2=19.02, 20.08, P<0.05);the gold medal school behavior formation rate (83.3%) was higher than that of silver and bronze school (76.2%, 75.4%) (χ2=30.57, 38.76, P<0.05), silverbehavior formation rate (76.2%) was higher than the that of bronze medal schools (75.4%) (χ2=3.99, P<0.05). Conclusion The school health promotion work is still focusing on health knowledge education stage, the awareness rates of knowledge and behavior formation rates are not completely consistent. Health promotion has not become a liability and the concept of the schools surveyed.

Renal function is closely associated with the risk of mortality ,cardiovascular events ,and progression to end stage of renal disease for patients with chronic kidney disease ( CKD ).Equations for estimated glomerular filtration rate ( GFR) based on serum creatinine or Cystatin C are frequently used in clinical evaluation of renal function.Although renal function can be more accurately assessed due to improvement in equations for estimated GFR ,it is difficult to overcome the inherent defect of creatinine based GFR estimation.Abundant ,evidence showed that Cystatin C based GFR estimation presented higher accuracy of prognosis assessment in CKD patients than creatinine based GFR estimation ,thus reduce the unnecessary nephrologist referral and measurements for low risk patients ,and also guarantee the timely recognization and intervention for high risk patients.This article deeply reviewed the role of serum creatinine or Cystatin C played in CKD diagnosis and prognosis assessment.

Objective To investigate the clinical significance of detecting the homocysteine (Hcy) level by enzymatic cycling as‐say before and after radiotherapy in nasopharynx cancer .Methods 62 cases of definitely diagnosed nasopharynx cancer in our hos‐pital from September 2013 to September 2014 were included into the observation group and 60 individuals undergoing the physical examination were enrolled as the control group .The venous blood was collected once in the control group and was collected before radiotherapy and at 1 week ,1 month after the radiotherapy beginning in the observation group .The enzymatic cycling assay was used to test the Hcy level .Then the detection results were compared between the two groups .Results The Hcy level had no statis‐tically significantly difference among different stages of nasopharynx cancer before radiotherapy (F= 0 .15 ,P= 0 .86) .The Hcy level before radiotherapy and at 1 week after radiotherapy in the observation group were significantly higher than that in the control group ,the difference was statistically significant (t= - 12 .1 ,P< 0 .05 ;t= - 7 .32 ,P= 0 .00) .The Hcy level at 1 month after radio‐therapy in the observation group had no statistical difference compared with that in the control group (t= - 1 .45 ,P = 0 .15) .The Hcy level at 1 week and 1 month after radiotherapy in the observation group was significantly reduced ,which showed statistical difference compared with before radiotherapy (t= - 5 .22 ,P= 0 .00 ;t= - 13 .56 ,P= 0 .00) .Conclusion The Hcy level in the pa‐tients with nasopharynx cancer is significantly increased ,whereas with the conducting radiotherapy ,which shows the decreasing trend ,indicating that the Hcy level has certain guidance value for the diagnosis and treatment of nasopharynx cancer ,but the Hcy level has no obvious difference among different stages of nasopharynx cancer .

The paper introduces concept, value, content, composition and frame theory of the overall informatization framework, an-alyzes the requirements of regional health informatization, summarizes the main modes of regional health informatization construction in China and elaborates the overall framework of regional health informatization and positioning of each composing factors, in order to provide references for regional health informatization construction in various regions.

Objective To establish the rat myocardial infarction model to observe the effects of different kinds of doses of simv-astatin for inhibiting the oxidative stress after myocardial infarction ,and to explore the potential mechanism of different doses of simvastatin for improving the rat ventricular remodeling and cardiac function .Methods The coronary artery anterior descending branch was ligated for establishing the myocardial infarction rat model and the different doses of simvastatin (20 ,40 ,60 mg · kg -1 · d-1 ) were given for intervention .After 4 weeks ,the cardiac ventricular remodeling indicators ,superoxide dismutase(SOD) and cop-per zinc superoxide dismutase(CuZn-SOD) activity in myocardium ,blood H2 O2 level were detected and the detection results were compared with those in the sham operation group .Results The rat ventricular remodeling in the myocardial infarction group (M group) was significant ,the left ventricular mass index (LVWI) was elevated ,the heart rate was increased and the hemodynamics was disordered(P<0 .05) .The SOD and CuZn-SOD expression in the myocardium and blood H2O2 expression were elevated(P<0 .05) .The LVW1 in different doses of simvastatin intervention groups were decreased compared with the myocardial infarction group(P<0 .05) ,the heart rate was decreased ,SOD and CuZn-SOD expression and blood H2 O2 expression were decreased ,the he-modynamics was improved(P<0 .05) ,especially which in the high dose atorvastatin intervention group (60 mg · kg -1 · d-1 ) were more significant .Conclusion Simvastatin reduces the expression of oxidative stress after acute myocardial infarction ,which may be one of the mechanisms for improving the ventricular remodeling and heart function ,and has certain positive correlation with dose .