Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

Humans ; Periodontal Diseases ; complications ; microbiology ; Periodontium ; microbiology ; Systemic Inflammatory Response Syndrome ; microbiology

China has not established the national long-term care insurance system, the long-term care expenses being mainly borne by the family, which leads to an unclear long-term care service utilization. This paper analyzes the impact of medical and pension insurance on the long-term care expenses for the Chinese disabled elderly by con-structing a two-part model based on the data of Chinese elderly longitudinal healthy longevity survey conducted in 2011 . The results showed that the long-term care expenditure of the urban elders with disabilities is significantly high-er than that of the rural ones. Although free public health insurance, the New Rural Cooperative medical insurance and endowment insurance have certain impact on the elderly long-term care expenditure, their effectiveness is differ-ent between the rural and urban areas. The urban elders' medical and pension insurance exerts influence on both the existence and the amount of the long-term care expenses. However, the rural elders' medical and pension insurance only have impact on the existence of the long-term care expenses, but the effect is not significant. It is suggested that China has to strengthen medical and pension insurance and build long-term care insurance system to lighten the finan-cial burden of the families of elders with disabilities.

OBJECTIVE:To establish an RP-HPLC method for the determination of Berberine hydrochloride in Keyang-min tincture.METHODS:The sample separation was performed on Agilent Eclipse XDB C18(250 mm?4.6 mm,5 ?m),and the mobile phase was acetonitrile-5 mmol?L-1 perfluorooctane sulfonate(32∶68) at flow rate of 1 mL?min-1.The detection wavelength was 346 nm and the temperature of column was 35 ℃.RESULTS:The linear range of Berberine hydrochloride was 0.059 2～0.888 3 ?g(r=0.999 9).The average recovery rate was 99.71%(RSD=1.18%,n=6).CONCLUSION:The met-hod is sensitive,accurate,and reproducible,and suitable for the determination of Berberine hydrochloride in Keyangmin tincture.

OBJECTIVE:To objectively look upon and analyse the influence of WTO entry on wholesale and retail of Chinese pharmaceutical businessMETHODS:Using comparative method,the influence of WTO entry was analysed concerning wholesale and retail of drugs,economically developed and developing districts,psychological and practical pressureRESULTS & CONCLUSION:Based on the analytic results,Chinese pharmaceutical business should avoid pell-mell development,enhance confidence,actively deal with the impact and seize the opportunity to seek to live on and to develop

OBJECTIVE:To establish a method for the content determination of Vincristine sulfate for injection. METHODS:HPLC was performed on the column of Agilent HC-C8 with mobile phase of 1.67% Diethylamine aqueous solution(adjusted to pH 7.5 with phosphoric acid)-methanol(38:62,V/V)at a flow rate of 1.0 ml/min,the detection wavelength was 297 nm,the column temperature was 35℃,and the injection volume was 10μl. RESULTS:The linear range of vincristine sulfate was 0.032-3.2 mg/ml (r=0.999 9);RSDs of precision,stability and reproducibility tests were lower than 1%;recovery was 99.3%-101.7%(RSD=0.6%,n=9). CONCLUSIONS:The method is accurate,reliable and sensitive,and can be used for the content determination of Vincristine sulfate for injection.