With the appearance of new biological agents represented by infliximab,the medical therapy of crohns' disease has made breakthrough of progress.However,the controversial still remains about the use of infliximab during perioperative period in Crohn's disease patients.The aim of this article is to explore the influence of infliximab on postoperative complications in Crohn's disease patients.

Humans ; Lead ; urine ; Lead Poisoning ; diagnosis ; urine ; Spectrometry, Fluorescence ; methods ; Spectrophotometry, Atomic ; methods

Objective To investigate the clinical outcomes of patients with chronic hepatitis B and its influencing factors,and provide reference for the prognosis of patients with hepatitis B.Methods 102 patients with chronic hepatitis B from January 2009 to June 2014 were selected and divided into the case group of 32 patients and the control group of 70 patients according to whether to occur with cirrhosis or liver cancer.The two groups of patients were analyzed and compared for general information,HBV DNA,serum ALT and other indicators.Results The cumulative cases of negative HBsAg,chronical hepatitis B,liver cirrhosis and liver cancer were 5,65 and 32,respectively.Univariate Logistic regression analysis showed that the differences between the two groups in age,sex,drinking history,HBV DNA levels and serum ALT levels were statistically significant (all P ＜ 0.05).Whether to cirrhosis or liver cancer was the dependent variable,the statistically significant single factors between the two groups were the independent variable,multivariate Logistic regression analysis showed that older age,male sex,alcohol abuse,high level of HBV DNA and high level of serum ALT were the risk factors of leading to cirrhosis,liver cancer for the patients with chronic hepatitis B (OR values were 9.94,14.36,8.25,13.01,120.32,respectively).Conclusions The older age,male,alcohol history,high level of HBV DNA and high level of serum ALT are higher risk factors for patients with chronic hepatitis B to development of cirrhosis and liver cancer.Patients with risk factors should be gave systematic interventions to reduce progression to cirrhosis,liver cancer and improve the quality of life.

Periodicals as Topic

China ; Humans ; Liver Diseases

Genetic Therapy ; Hepatitis B ; therapy ; Hepatitis C ; therapy ; Humans ; RNA Interference ; RNA, Small Interfering ; genetics ; RNA-Induced Silencing Complex ; genetics

Antiviral Agents ; therapeutic use ; Hepatitis B, Chronic ; drug therapy ; Humans

Consuming an adequate amount of iodine during pregnancy is critical for fetal neurologic development.Even a mild deficiency can impair cognitive ability.The World Health Organization recently has increased their recommended iodine intake during pregnancy from 200 to 250 μg/d and suggested that a median urinary iodine concentration of 150 ～ 249 μg/L indicates adequate iodine intake in pregnant women.Whether mild-to-moderate maternal iodine deficiency produces more subtle changes in cognitive function in offspring is unclear;no controlled intervention studies have measured long-term clinical outcomes.This review summarizes the iodine nutrition of pregnant women,and the effects of iodine deficiency in pregnancy on neurodevelopment in the child.To prevent fetal damage,iodine should be given before or early in pregnancy.

BACKGROUND:It is reported that long-term endurance training can induce the transformation of muscle fibers and the myosin heavy chain (MHC) isoforms from the fast type into the slow type. But the change of MHC isoforms mRNAs in the movement training needs further study.OBJECTIVE: To observe the effect of the treadmill training on the contractile function of gastrocnemius MHC in male SD rats.DESIGN: A randomized controlled animal experiment.SETTING: Medical Experimental Center of Xi'an Jiaotong University.MATERIALS: Totally 40 male SD rats aged 7 weeks with the body mass of (230±16) g were selected. All the animals had not experienced the treadmill exercise before the experiment. Reagents: The primary antibodies were the murine anti-actin and anti-MHC Ⅱ of fast contractile type of skeletal muscle monoclonal antibodies, ABCam products. The secondary antibody was the alkaline phosphatase-conjugated anti-murine IgG, SIGMA product.METHODS: The experiment was conducted at the Medical Experimental Center of Xi'an Jiaotong University from March to October 2005. All the rats were randomly assigned into control group (n =10) and training group (n =30). The rats in the training group took movement training for 4-6 weeks with the exercise intensity of 75%VO2max (18.5-24 m/min,gradient of 0°), once 50 minutes and twice a day. The rats in the control group did free exercise, and did not receive any intervention. At weeks 4, 5 and 6, MHC mRNA content was measured by reverse transcription-polymerase chain reaction (RT-PCR) and change of myosin muscle fibers and size of cross section area (CSA) were determined by immunohistochemical method in 10 rats. The rats were anesthetized before the gastrocnemius liberated gently. Tension transducer and electrical stimulator were applied to give square wave pulse stimulation. The gastrocnemius was extended gradually till the Lmax position of initial length of muscle, at which the isometric contraction tension reached the maximal value for 10 minutes. The muscle length and tension were recorded. The right-side gastrocnemius was obtained to measure the wet weight, and the ratio with the body mass was calculated. The ratio of muscle mass to body mass was determined by the following formula: muscle mass (mg)/body mass (g) ×100%.MAIN OUTCOME MEASURES: ①MHC mRNA content of gastrocnemius, ②change of myosin muscle fibers and size of CSA, ③body mass of rats and gastrocnemius mass, and ④maximal tension of isometric contraction of gastrocnemius.RESULTS: A total of 40 included rats were involved in the result analysis. ①MHC mRNA content of gastrocnemius: The expression of total MHC mRNA of the training group was 105% of that of the control group after the endurance training for 4 weeks (P ＜ 0.01). The expression of MHC Ⅱ a was higher than that in the control group (1.27±0.08,1.17±0.06, P ＜ 0.05). The expression of MHC Ⅱ x mRNA was higher than that in the control group (1.29±0.04,1.19±0.05, P ＜ 0.01 ).②change of myosin muscle fibers and size of CSA: the MHC of rats had the main expression of the Ⅱ slow contractile type of muscle fibers, but less expression of Ⅰ fast contractile type of muscle fibers ratio after 4-6 weeks aerobic exercise. The CSA of type Ⅰ and type Ⅱ muscle fibers of the rats in the control group were (1 958.0±30.5), (1 656.1± 35.3) μm2, respectively. However, as compared with the control group, the CSA of type I and type Ⅱ muscle fibers of the rats in the four-week-training group increased by 24.5 % and 22.1% (P ＜ 0.01) respectively. In the five-week-training group, the related value increased by 26.4 % and 51.5 % (P ＜ 0.01), respectively. In the six-week-training group, the related value increased by 33.2% and 48.9% (P ＜ 0.01), respectively. ③body mass of rats and gastrocnemius mass:The wet weight of gastrocnemius [(135.6±3.1 ), (139.2±5.1), (148.4±6.2) mg] was higher in the training group than the control group [(103.2±3.4), (87.5±2.9), (68.3±3.3) mg,P ＜ 0.01] at weeks 4, 5 and 6. Relative weight of gastrocnemius [(0.55±0.01), (0.56±0.02), (0.59±0.03)] was higher in the training group than the control group [(0.43±0.02), (0.37± 0.04), (0.29±0.05),P ＜ 0.05-0.01] at weeks 4, 5 and 6. ④maximal tension of isometric contraction of gastrocnemius:The maximal tension of isometric contraction increased significantly in the training group as compared with the control group after square wave pulse stimulation at week 6 (P ＜ 0.01).CONCLUSION: Expression of MHC Ⅱ x and MHC Ⅱ b, the CSA of muscle fibers and the maximal tension of isometric contraction are all increased after the short-term endurance training. It indicates that the aerobic exercise may promote the contractile function of MHC.

Objective Study on the clinical application valence of desensitization treatment bronchial asthma and the relationship of inhalation allergen and bronchial asthma.Method Using inhalation allergen,the patients of bronchial asthma were intradermal tested;80 asthmaic patients are randomly divided into 2 groups:1 of 2 desensitization treatment,the second as control group.The therapy endures 8～12 months.Clinical effects are observed.Results 80 cases in 80 cases bronchial asthma test were poisitive (100%);desensitization treatment for 8～12 months can achieve optimal symptom control.Recurrence rate of 2 years in 56 cases desensitization treatment were magnificently lower than control group (χ2=9.95,P<0.01).Conclusion Desensitization treatment is an effective method in the therapy of bronchial asthma.