Objective To analyze the effect of Ligustrazine combined with cephalosporin on the elderly patients with acute attack of chronic bronchitis. Methods From April 2015 to May 2017 selected 72 patients with chronic bronchitis acute attack were divided into group A and groupB according to the different treatment options, 36 cases in each group. Group B were received single cephalosporin antibiotics, while group A were given ligustrazine combined with cephalosporin antibiotics. The improvement of cough and other symptoms and the antipyretic time and other indexes were compared in the two groups. Results The time of disappearance of the positive signs of the lung, the antipyretic time and the time of cough disappearance in group A were significantly shorter than those in group B(P<0.05). The total effective rate in group A was 94.44％, which is significantly higher than the 72.22％ in group B(P<0.05). Conclusion Ligustrazine combined with cephalosporins on the treatment of the elderly patients with acute attack of chronic bronchitis can significantly improve the curative effect, which is worthy of clinical application.

Objective To investigate the effect of auricular point sticking on insomnia in patients undergoing maintenance hemodialysis.Methods Sixty-four patients undergoing maintenance hemodialysis as well as suffering from insomnia were randomly divided into observation group and control group with equal number:The control group were treated by administering 1mg estazolam before going to bed and the observation group by auricular point sticking based on TCM theory.The two groups were compared in terms of score by Pittsburgh sleep quality index(PSQI)as well as the curative effects at weeks 4 and 8,respectively.Results The scores by PSQI in the observation group were significantly lower that those of the control group at the two time points(P<0.05,for both)and the sleep curative effect in the former was significantly better than the latter(P<0.05).Conclusion The auricular point sticking based on TCM theory is more effective than therapy right with western medicine in the treatment of insomnia in patients undergoing maintenance hemodialysis.

The author thinks the causes of foreign language anxiety includes the imbalance between input and output,the neglect of individual differences because of the teacher-centered input model and the passive affects of dull classroom environment etc. Meanwhile,from the author's point of view,teachers should realize the passive affects of foreign language anxiety,and try to overcome it in the teaching process.

The cultivation of clinical ability is also very important for postgraduate students in neurosurgery besides the cultivating of innovative scientific research ability and the quality-ori-ented education.We think that attention should be paid to issues such as emphasizing the educa-tion in humanities and the cultivation of good medical ethics and medical style,stressing the training of medical communication capability,re-teaching of basic neurosurgical knowledge,im-proving basic clinical skills,and strengthening the cultivation of scientific clinical thinking.

Objective To study the clinical value of combined detection of the serum levels of AFP, CA125, CA199 and CEA in the diagnosis of primary hepatic carcinoma (PHC). Methods Serum levels of AFP, CA125, CA199 and CEA in 68 patients with PHC, 50 patients with benign liver disease and 58 normal controls were measured by Electrochemiluminescence immuno-assay (ECLIA). Results The levels of AFP, CA125, CA199 and CEA in PHC group were significantly higher than those in benign liver disease and normal controls. Sensitivities of AFP, CA125, CA199 and CEA were 76.4 %, 35.3 %, 44.1%, 29.4 %, respectively. Sensitivity of combined detection of four kinds tumor markets was 94.1%. Conclusion Combined detection of four kinds of serum tumor markers is useful to increase the detective positive rate in the diagnosis of PHC.

Asian Continental Ancestry Group ; Cardiovascular Diseases ; ethnology ; prevention & control ; Humans

Hypoxia-inducible factor-1(HIF-1) is a key factor in hypoxic response of cells.It plays an important role in embryonic development,cerebral infarction,cerebral hemorrhage,hypoxic-ischemic encephalopathy,neurodegenerative diseases,cancers and other physiological or pathological processes.Studies have confirmed that in developing rats,the expression of HIF-1 α mRNA and HIF-1α in hippocampus after status epilepsy enhanced obviously,and it is related to proliferation of neural stem cells.Although some experiments have explored the relationship between certain signaling pathways and HIF-1 α,no experiments come to the signal-regulation in the expression of HIF-1α after epilepsy.

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting joints. Proteomics is a new field of studying the protein and its dynamic axiom of transmutation in cells. Two-dimensional gel electrophoresis, mass spectrometry and bioinformatics are the three major technology. Recently,the research in rheumatoid arthritis proteomics has made great progress. Application of proteomics technology is designed to study the pathogenesis from the proteins levels,finding out the marker proteins in order to improue RA diagnosis, treatment and prognosis.

Multiple myeloma (MM) is a malignancy of the plasma cells, characterized by complex karyotype and chromosome instability. These cytogenetic changes are important prognostic indicators in MM patients. Fluorescence in situ hybridization (FISH) can analyze a large number of interphase cells without metaphase. It is simple, reproducible, highly sensitive and specific. It has more prominent advantages in the research of MM without informative metaphase. FISH can detect microdeletions in genetic loci that are closely related to disease prognosis, therefore significantly improves the abnormal clone detection rate. FISH provides a theoretical foundation for the diagnosis, clinical classification and prognosis prediction, and can guide the personalized therapy of MM.

Objective To compare the effects of two types of peripheral venous insertion of catheter in elderly patients with neurogliocytoma.Methods A total of 336 neurogliocytoma patients received intravenous drug treatment were randomly divided into two groups:midline catheter group (n =168) and periphery catheter group (n=168).The time course of venous insertion of catheter,frequency of insertion,time of catheter reservation,incidence of insertion complications and degree of satisfaction in patients were recorded.Results The time course of venous insertion and the time of catheter reservation were longer in midline group than in periphery group [(25.3±1.8) min vs.(0.8±0.1) min,(27.5±1.0) d vs.(2.9±0.4) d,respectively,both P＜0.05].The frequency of insertion and the incidence of phlebitis were lower in midline group than in periphery group [(1.1±0.3) vs.(12.2±0.4),8 cases (4.8％) vs.51 cases (30.4％),respectively,both P＜0.05].There were no significant differences in catheter occlusion,migration and removal between the two groups (all P＞ 0.05).The degree of satisfaction was higher in midline group than in periphery group (89.0％ vs.63.0％,P ＜ 0.05).Conclusions It is suitable for elderly patients with neurogliocytoma to recieve intravenous drug treatment by midline catheter insertion.Midline catheter insertion can reduce the incidence of phlebitis and puncture damage,and elevate the degree of satisfaction.