The experiments were based on animal models of arthritis caused by II collagenous immunity with the theories of wind- damp- cold as its exogenous factor and kidney deficiency as its endogenous factor The animal models of combined type of syndrome and disease were induced by method of complex facotrs based on the study of kidney nature by integrated modality. Exploration was made on the influence of pathogensis in deficient kidney caused by various methods. Preliminary conclusion showed that such influence yielded different results.