No abstract available.
Alzheimer Disease*

No abstract available.
Alzheimer Disease*

Objective To investigate the relationship between neurofilament light chain protein （NfL） and clinical features in patients with Alzheimer disease. Methods We included 58 patients with Alzheimer's disease admitted to Ningbo No. 2 Hospital from June 2020 to December 2021. NfL levels were measured for the 58 patients with Alzheimer's disease. Correlation analysis was performed to study the correlation between NfL and age， disease course， hippocampal grade， Activities of Daily Living（ADL） score， Mini-Mental State Examination （MMSE） score， and Hasegawa Dementia Scale （HDS） score. The Pearson correlation coefficient （r） represented the strength of correlation. Results Among the 58 patients， 33 were females， with a mean NfL level of（24.93±17.07）pg/mL， and 24 were males， with a mean NfL level of 28.14 ± 17.98 pg/mL， which were not significantly different. NfL levels for different educational attainments had no significant difference： illiteracy （7/58），（27.87 ± 14.75）pg/mL；primary school（7/58），（15.22±9.62）pg/mL；middle school （14/58）， （27.95±15.60）pg/mL； high school（4/58），（12.84±2.97）pg/mL； technical secondary school（7/58）， （37.35±26.63）pg/mL； junior college （5/58），（33.79±21.81）pg/mL； and university （7/58），（15.22±9.62）pg/mL. NfL was positively correlated with age （r=0.448） and hippocampal grade（r=0.345）， and not significantly correlated with the course of disease（r=0.045，P>0.05）， ADL score （r=0.242，P>0.05），MMSE score （r=‒0.099，P>0.05），and HDS score （r=‒0.096，P>0.05）. Conclusion Serum NfL levels in patients with Alzheimer disease are positively correlated with age and hippocampal grade on magnetic resonance imaging， but not associated with sex， education attainments， the course of disease，ADL score，MMSE score，and HDS score.
Alzheimer Disease

No abstract available.
Alzheimer Disease* ; Dementia ; Presenilins*

No abstract available.
Alzheimer Disease* ; Brain Injuries*

No abstract available.
Alzheimer Disease* ; Neurons* ; Neuropeptides*

No abstract available.
Alzheimer Disease ; Autopsy

No abstract available.
Alzheimer Disease* ; Dementia*

Most of the research activities on dementias have been and are focused on Alzheimer's disease. With regard to the treatment possibility and the cause and pathogenesis of cognitive impairment, however, non-Alzheimer dementias are also very important. We should extend our efforts to other dementing diseases than Alzheimer's disease.
Alzheimer Disease ; Cognition ; Dementia*

Objectives: White matter hyperintensities are known to influence dementia in Alzheimer’s disease. Genetic components are suggested as putative risk factors for vascular pathology and cognitive decline. This study aimed to determine whether there is an association between candidate genetic polymorphisms and the severity of white matter hyperintensities in patients with Alzheimer’s disease. Methods: Seventy-five patients diagnosed with Alzheimer’s disease underwent genetic tests for specific alleles of apolipoprotein E, angiotensin-converting enzyme, and methylenetetrahydrofolate reductase. All patients underwent brain magnetic resonance imaging scans and neuropsychological tests. The severity of white matter hyperintensities was semiquantified using the CREDOS rating scale, and patients were divided into three groups according to their rating. Results:The severity of white matter hyperintensities was related to age and hypertension. However, none of the gene polymorphisms we tested was found to be associated with the severity of white matter hyperintensities. Conclusion:The genetic polymorphisms found in apolipoprotein E, angiotensin-converting enzyme and methylenetetrahydrofolate reductase did not contribute to white matter hyperintensities in Alzheimer’s disease.Only age and hypertension factors were found to be contributory to white matter hyperintensities.
Alzheimer Disease ; Dementia