Introduction: Erectile dysfunction (ED) has numerous links to cardiovascular disease. Numerous studies show the severity of ED is strongly associated with atherosclerosis and endothelial dysfunction implicated in the pathogenesis of coronary artery disease (CAD). These common vascular pathways have led to evidence that ED onset may be used as a marker of the severity of CAD as well as a preclinical marker of early onset-CAD. The researchers aim to determine the association of ED and CAD in terms of prevalence, clinical presentation and severity and extent of vessel involvement by SYNTAX score among CAD patients undergoing coronary angiography. Methods: This is a prospective, cross sectional, analytical study design set at Perpetual Succour Hospital – Cebu Heart Institute, a private, tertiary hospital with cardiac specialty units located in Cebu City. This study includes all Filipino patients admitted at Perpetual Succour Hospital suspected to have coronary artery disease based on symptoms of angina, dyspnea or other anginal equivalent with indications to undergo coronary angiography during the period of October 1, 2014 to September 30, 2015 were included. Results: A total of 160 patients were included in the study. The mean age is 57.23 years with most of the patients admitted for stable ischemic heart disease (SIHD) of 54.7%, non-ST elevation acute coronary syndromes (NSTEACS) 33.5% and ST-elevation myocardial infarction (STEMI) 11.8% with multiple cardiovascular risk factors like hypertension, diabetes mellitus, smoking and dyslipidemia. Eighty-two percent complained of ED symptoms with a mean International Index of Erectile Function (IIEF) score of 15.15. Most ED patients identified had mild to moderate ED (31.7%), mild ED (21.7%), moderate ED (17.4%) and severe ED (11.8%). There were only 17.4% of patients who had undergone coronary angiography for CAD complaints that had no ED symptoms on admission. Per clinical presentation, there was a significant association between patients presenting with severe ED, moderate ED and mild to moderate ED with those presenting with SIHD and ACS-NSTEMI on admission, moderate ED and mild to moderate ED. ED was significantly associated with obstructive CAD (p=0.001) and correlated directly with the number of vessels involved (p<0.01) and inversely related to SYNTAX scores (p<0.001). ED symptoms were noted to precede CAD diagnosis by 4.9 to 5.9 years. Conclusion In conclusion, there is a high prevalence of ED among CAD patients and its existence is significantly associated with obstructive CAD varying directly with extent and number of vessel involvement. There is a significant inverse relationship with severity of ED and SYNTAX scores. The existence of ED was present in all subsets of CAD patients, regardless of presentation of admission and preceded CAD symptoms and diagnosis by four to five years.
Erectile Dysfunction ; Coronary Artery Disease

Objectives: This cross-sectional study evaluates the degree of agreement between the 2018 American College of Cardiology/American Heart Association (ACC/AHA2018) and 2020 Philippine Guideline (PG2020) treatment algorithms for the primary prevention of dyslipidemia among Filipinos. Methodology: This review included 159 charts of statin-naive Filipinos who are 45-79 years old. Using risk profile and lipid measurements, statin treatment recommendation was determined through the PG2020 algorithm and ACC/AHA-ASCVD Risk Estimator Plus web application. The degree of agreement was measured by Cohen’s kappa statistic with the two algorithms as independent raters. Results: A total of 159 patients were included in the final analysis. There was a slight agreement with a kappa coefficient of 0.209 or 4.4% (95% CI 0.078-0.340, p=0.003). Statin treatment was recommended in 69 out of 159 patients (43.4%) by the PG2020 overlapping with ACC/AHA2018 in 56 cases (81.2%). On the other hand, 109 cases (68.6%) were recommended for statin treatment by ACC/AHA2018 overlapping with PG2020 in only 51.4%. Conclusions The low degree of agreement between the two treatment algorithms highlights the key demographic and ethnic variations in dyslipidemia management necessitating outcome-based studies to translate these differences. Overestimation of ASCVD risk calculation in the ACC/AHA2018 and consideration of important, unique risk factors among Filipinos favors the applicability of the Philippine guideline.
Dyslipidemias ; Hypercholesterolemia ; Algorithms ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Primary Prevention