ss of wound healing after administration ofmitomycin-C, which inhibits granulation tissue formationand collagen synthesis, resulting in chronic wounds. Thevitreous gel of cow eyeballs contains a high level ofhyaluronic acid, which has a role in inflammation,granulation, re-epithelialization, and remodelling. This studyaims to understand the effect of 1% povidone iodine andvitreous gel of cow eyeballs on wound healing afteradministration of mitomycin-C.Methods: This was an invivostudy with quasi-experimentalmethods on 32 Wistar mice. Full-thickness wounds weremade and then treated with mitomicyn-C. The mice weredivided into 4 groups: a control group with NaCl 0.9%vitreous gel of cow eyeball (VGCE), 1% povidone-iodine, anda combination of VGCE and 1% povidone-iodine groups.Macroscopic and microscopic observations of the processof wound healing were performed on days 3, 7, and 14.Results: Vitreous gel administration produced significantwound healing rates within the first three days, andhistological analysis revealed an increased number offibroblasts and polymorphonuclear cells. However, thepovidone iodine group and the combination group withvitreous gel did not produce significant results.Conclusion: The single administration of VGCE canaccelerate the wound healing process, increase the numberof fibroblasts, and reduce inflammation in a chronic woundmodel.

Introduction: Testicular torsion is a urological emergency causing spermatic cord twisting. Delayed management can cause poor outcome, i.e. orchiectomy. Here, we investigated several prognostic factors, including age, onset, clinical symptoms, leukocyte count, for testicular torsion outcomes (orchiectomy vs. orchiopexy) in children in Indonesia. Methods: A retrospective review of 23 patients with testicular torsion who underwent scrotal exploration from July 2013 to November 2018 at our institution was done. Results: The age at testicular torsion diagnosis was 12.8 (interquartile range, 4.6-15.1) years. Only fever showed strong significant prognostic factor for orchiectomy (OR=20; 95% CI=1.6 – 248; p=0.017), while other factors were not, with p-value of 0.54, 1.0, 1.0, 0.19, 1.0, 0.62, 0.62, 0.58, and 0.62, for age, onset, scrotal pain, abdominal pain, hyperemia, edema, nausea, vomitus and white blood cells count, respectively. Furthermore, logistic regression test also revealed that fever is a strong prognostic factor for orchiectomy (OR=22.6; 95% Cl=1.3 – 394.2; p=0.033). Conclusion: The patient with testicular torsion with fever tends to undergo orchiectomy. Further multicenter studies with a larger sample size are necessary to confirm our findings.