Objective To observe the effect of radiotherapy combined with chemotherapy for patients with cardia cancer who could not take operational treatment.Methods 37 patients with advanced cardia cancer received treatment of 6MV-X linear accelerator convention radiotherapy for 6 weeks.After taking radiotherapy,they received chemotherapy with DDP(20mg) and 5-Fu(500mg) for 3～6 cycles.Results The clinical symptom obviously alleriates,X-ray barium medicinal preparation absorbs the piece to demonstrate the complete response rate of 8%(3/37),the total effectiveness rate was 87%(32/37).1,3-years survival rates respectively were 65% and 11%.Conclusion Radiotherapy combined with chemotherapy for advanced cardia cancer can improve the clinical symptom and improve the surviral quality and lengthen the life.