1.Correlation between positive psychological capital and quality of life in patients with diabetic retinopathy
Chinese Journal of Practical Nursing 2021;37(10):726-732
Objective:To explore the correlation between positive psychological capital and quality of life in patients with diabetic retinopathy, and to provide a reference for the development of targeted nursing measures to improve the quality of life of patients.Methods:A total of 226 patients with diabetic retinopathy who were hospitalized in the Department of Ophthalmology and Endocrinology of the First Affiliated Hospital of China Medical University from May to December in 2019 were selected by convenient sampling. The data were investigated by general data questionnaire, positive psychological capital questionnaire for patients with diabetic retinopathy, and National Eye Institute 25-Item Visual Function Questionnaire.Results:The positive psychological capital score of patients with diabetic retinopathy was (72.08±9.42) points; the quality of life score was (52.10±18.22) points; positive psychological capital was positively correlated with quality of life ( r value was 0.571, P<0.01). Conclusions:The positive psychological capital of patients with diabetic retinopathy is positively related to the quality of life. Nursing staff should take measures to improve the level of positive psychological capital of patients, promote their mental health, and improve their quality of life.
2.Efficacy of percutaneous laser disc decompression combined with injection of collagenase through a target location for treatment of lumbar intervertebral disc protrusion
Kaiqiang WANG ; Aiping HUANG ; Lei XIE ; Jindi ZHENG ; Haosheng BI
Chinese Journal of Anesthesiology 2010;30(12):1459-1461
Objective To investigate the efficacy of percutaneous laser disc decompression(PLDD)combined with injection of collagenase through a target location for treatment of lumbar intervertebral disc protrusion.Methods Ninety patients with lumbar intervertebral disc protrusion scheduled for discolysis,aged 31-52 yr,weighing 58-70 kg,were randomly divided into 3 groups: PLDD group(group P,n = 29),collagenase injection group(group C,n = 31),PLDD combined with injection of collagenase through a target location group(group PC,n = 30).The puncture was performed under the guidance of CT.Group P was treated using PLDD.Group C was treated with collagenase injection.Group PC was treated with injection of collagenase after PLDD was completed.The therapeutic effect was assessed before operation and on day 7,30,60 and 90 after operation using M-JOA score.Results M-JOA grade was significantly higher at the each time point after operation in group P and PC,and on day 30,60 and 90 after operation in group C than that before operation(P < 0.05).M-JOA grade was significantly lower on day 30 after operation in group P,while higher on day 30,60 and 90 after operation in group C and PC than that on day 7 after operation(P < 0.05).M-JOA grade was significantly lower at the each time point after operation in group P and C than in group PC.Conclusion The therapeutic effect of PLDD combined with collagenase injection through a target location is stable for treatment of lumbar intervertebral disc herniation and better than that of PLDD or collagenase injection alone.
3.Effects of sperm morphology, sperm DNA fragment index and seminal plasma zinc on pregnancy outcome of IVF-ET
Songcheng GAO ; Chunyu XIE ; Yan CHEN ; Aiping WANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(6):369-371
Objective To investigate the influence of sperm morphology, sperm DNA fragmentation index and seminal plasma zinc on pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET).MethodsA total of 341 infertile couples underwent IVF-ET were selected from January 2016 to June 2016 in our hospital.Sperm morphology, sperm DNA fragmentation index and seminal plasma zinc level were compared according to pregnancy.ResultsIn 341 cases, 204 cases pregnancy and 137 cases of no pregnancy, with the pregnancy rate of 59.8%(204/341).Compared with the pregnancy group, the percentage of normal sperm percentage was low, the abnormal sperm index was higher in the non-pregnant group (P<0.05), the sperm DNA index was higher (P<0.05).The percentage of normal sperm, sperm DNA fragmentation index and seminal plasma zinc and pregnancy rate in sperm morphology were linear (P<0.05), And there was a negative correlation between abnormal sperm index and sperm DNA fragment index (P<0.05), and other indicators were positively correlated (P<0.05).ConclusionSperm morphology, sperm DNA fragmentation index and seminal plasma zinc levels may influence the outcome of IVF-ET.The above parameters can be used to predict pregnancy outcome of IVF-ET.
4.The influence of the Pro12Ala mutation of PPARgamma2 receptor gene on beta-cells restoration and insulin resistance in type 2 diabetes with hypertension.
Aiping, ZHANG ; Muxun, ZHANG ; Jianhua, ZHANG ; Yikai, YU ; Junhui, XIE
Journal of Huazhong University of Science and Technology (Medical Sciences) 2005;25(6):648-50
The aim of this investigation was to determine whether a PPARgamma2 Pro12Ala polymorphism was associated with insulin resistance, beta-cell function and hypertension in Chinese populations. 289 unrelated Chinese subjects first diagnosed Type 2 diabetes (HbAC1 < 6.0) were investigated, including 132 hypertensive diabetic (HTD) subjects, 157 normotensive diabetic (NTD) subjects. Blood pressure and anthropometric measurements were collected from all participants, as well as several venous blood samples during oral glucose tolerance test (OGTT). Biochemical measurements (high-density lipoprotein (HDL) and low-density lipoprotein-cholesterol (LDL), triglycerides) and PPARgamma2 Pro12Ala genotype were also determined. And insulin resistance and beta-cells function was assessed by HOMA-IR and HOMA-beta respectively. The frequency of subjects bearing the Pro12Ala was lower in the hypertension group (3.03%) than in the non-hypertension group (5.7%) (P < 0.05) after adjusted for age, BMI and gender. Hypertensive diabetic Pro12Ala subjects had lower fasting plasma glucose level (P = 0.0127), and better glucose tolerance 60 min after oral glucose (P = 0.0361). Moreover, plasma insulin concentrations at 60 min was lower than those without A variant (P = 0.0275), and both hypertensive Ala/Pro in HOMA-beta (P = 0.0455) and AUC for insulin (P = 0.0473) were higher, and HOMA-IR was lower (P = 0.0375) as compared with hypertensive Pro/Pro subjects. No association was observed between Pro12Ala genotype and BMI, total cholesterol, HDL- cholesterol or triglycerides in either group. Our findings suggested that the Ala 12 allele of the PPARgamma2 gene may improve insulin resistance and ameliorate beta-cell function reserves in T2DM with hypertension, and protect patients from hypertension in T2DM. As an important thrifty gene, environment factors may exerts an effect of PPAR gamma2 on glucose homeostasis and insulin resistance.
Alanine/genetics
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Diabetes Mellitus, Type 2/complications
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Diabetes Mellitus, Type 2/*genetics
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Genetic Predisposition to Disease
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Hypertension/*complications
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Hypertension/genetics
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Insulin Resistance/*genetics
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Insulin-Secreting Cells/*physiology
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Mutation
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PPAR gamma/*genetics
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Proline/genetics
5.Application of PDCA in hospital medical record management
Meiying LI ; Zhihai XIE ; Yaozhi ZHI ; Liqing CHEN ; Yuewei XIE ; Aiping CHEN
Chinese Journal of Primary Medicine and Pharmacy 2016;23(11):1755-1758
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6.Efficacy of minimally invasive percutaneous intervertebral disc approach for treatment of sympathet-ic cervical spondylosis
Chunchun XUE ; Jianfeng CAI ; Xiaofeng LI ; Aiping HUANG ; Lei XIE ; Zhen GU ; Xia LI ; Kaiqiang WANG
Chinese Journal of Anesthesiology 2016;36(9):1106-1109
Objective To evaluate the efficacy of minimally invasive percutaneous intervertebral disc approach for treatment of sympathetic cervical spondylosis. Methods Fifty?six patients diagnosed as having sympathetic cervical spondylosis from January 2009 to August 2014, aged 22-64 yr, with the dis?ease course ranged from 6 months to 15 yr and a follow?up period of 6 months, were enrolled in the study. The related minimally invasive approach was selected according to the height of the diseased intervertebral space. When the ratio of the height of diseased intervertebral space∕normal intervertebral space≤1∕3, per?cutaneous radiofrequency ablation was used ( groupⅠ, n=19); when the ratio within the range of 1∕3-2∕3, percutaneous laser disk decompression was used ( groupⅡ, n=12); when the ratio≥2∕3, low?tem?perature plasma radiofrequency ablation was used ( group Ⅲ, n=25) . Before operation, at 2 weeks after operation, and at 1, 3 and 6 months after operation, the sympathetic symptoms were evaluated using the 20?point score. At 2 weeks and 6 months after operation, the patients′ subjective satisfaction was assessed and graded ( excellent, good, medium and poor ) . Results All the patients were followed up for 6 months. The sympathetic symptom scores were significantly lower at each time point after operation in Ⅰand Ⅲ groups and at 2 weeks and 3 and 6 months after operation in group Ⅱ than those before operation
( P<0.05) . The excellent and good rate of patients′subjective satisfaction was 67.9% at 2 weeks after op?eration, and 76.8% in the last follow?up period at 6 months after operation. Conclusion The minimally invasive percutaneous intervertebral disc approach has a marked short?term effect on sympathetic cervical spondylosis.
7.Clinical research of endoscopic great saphenous vein harvesting in coronary artery bypass grafting
Gang WANG ; Tao ZHANG ; Jian LI ; Lijun WANG ; Jing WANG ; Aiping XIE
Chinese Journal of Interventional Cardiology 2016;24(4):191-194
Objective To analtze and compare phe earlt clinical effecps of endoscopic versus convenpional greap sapenous vein harvesping undergoing and afper coronart arpert btpass grafping. Methods Endoscopic greap saphenous vein harvesping was performed in 298 papienps undergoing coronart arpert btpass grafping from Mar. 2010 po Jan. 2013. Clinical dapa of phe 298 papienps (EVH Group) were compared wiph anopher 309 papienps (CVH Group) in respecp of phe preoperapive dapa, operaping dapa and pospoperapive complicapions. Results No significanp difference was found bepween phe pwo groups in phe dapa of acquisipion pime, lengph of greap saphenous vein, number of btpasses, operaping pime, hospipalizapion pime afper operapion, rapes of incision sipe infecpion and hemapoma formapion, local skin necrosis and dermapipis (all P > 0. 05). Less complainp of lower limb pain (17. 4% vs. 51. 1% ), limb edema (0. 7% vs. 32. 7% ) and ltmphapic leakage (0 vs. 7. 4% ) was observed in phe EVH group as compared po phe CVH group (all P < 0. 01). Conclusions Use of endoscopic vein harvesping in coronart arpert btpass grafping can alleviape phe operapive wound and decrease phe incidence of local complicapion.
8.Effect of Sulfureted Hydrogen Bath on Spinal Cord Injury
Yi LI ; Aiping ZHANG ; Yinghong XIANG ; Xiaohua LI ; Jiangling LIU ; Weina XIE
Chinese Journal of Rehabilitation Theory and Practice 2012;18(9):863-865
Objective To explore the effects of motor training in sulfureted hydrogen miniral spring on neurological function after spinal cord injury (SCI). Methods 80 SCI patients were divided into treatment (n=40) and control group (n=40). They all accepted comprehensive rehabilitation, while the treatment group accepted motor training in sulfureted hydrogen miniral spring in addition. They were assessed with ASIA scale, modified Barthel index (MBI), Ashworth scale, visual analogue scale (VAS) and limbs circumference. Results There was not significant difference between both groups after treatment in ASIA scores of motor and sense, but was in Ashworth scale (P<0.05), VAS (P<0.01), limbs circumference (P<0.01), MBI (P<0.01, not in walk), which the treatment group improved more. Conclusion Motor training in sulfureted hydrogen miniral spring can further improve the activities of daily living and neurological function
9.Association between hormone receptors and response to neoadjuvant anthracycline-based chemotherapy in breast cancer patients
Yan WEI ; Jinfeng LI ; Tianfeng WANG ; Yuntao XIE ; Zhaoqing FAN ; Tie FAN ; Aiping LU ; Tao OUYANG ; Benyao LIN
Journal of Peking University(Health Sciences) 2003;0(05):-
Objective:To investigate the associations between the hormone receptors,Ki67 expression and response to neoadjuvant anthracycline-based chemotherapy in breast cancer patients.Methods:One hundred sixty-eight primary breast cancer patients received anthracycline-based neoadjuvant chemotherapy.The expression of estrogen receptor(ER),progesterone receptor(PR),and Ki67 were determined by immunohistochemistry assay in core-needle biopsy specimens prior to the chemotherapy,and pathologic response was assessed by Miller & Payne grade(G1 to G5).Results:40%(67/168)of the patients had a good pathologic response,defined as complete pathologic response(pCR or G5)and minimal residual disease(G4).Among the patients,20%(33/168)had a complete pathologic response(G5).ER or PR status was significantly associated with pathological response.Patients with PR-negative tumors had a higher pathological response rate or pCR than those with PR-positive tumors(17/67 vs 45/90,P=0.002;6/67 vs 25/90,P=0.003,respectively),whereas patients with ER-negative tumors had a higher pathological response rate than those with ER-positive tumors.Moreover,Patients with both ER-and PR-negative tumors exhibited a remarkable pathological response as compared with those with any single factor(36/17 vs 26/86,P=0.009).No association between Ki67 expression and pathological was found in this cohort of patients.There was a linear correlation between the expression of Ki-67,ER or PR status and pathologic response.Conclusion:There is a significant association between the hormone receptors and pathological response to neoadjvant anthracycline-based chemotherapy in breast cancer patients,and patients with PR-negative tumors are more likely to respond to chemotherapy.
10.Expression of urea transporters in sweat gland tissue of normal subjects and uremic patients.
Jing LIU ; Liyi XIE ; Aiping YIN
Journal of Southern Medical University 2013;33(7):951-955
OBJECTIVETo explore the expression of urea transporters (UTs) in the skin and sweat glands of normal subjects and patients with uremia.
METHODSAbdominal skin biopsy samples of patients with uremia and normal patients and apocrine sweat gland tissue from patients with bromidrosis were examined for the expression of UTs using immunohistochemistry and fluorescence immunoassay for quantitative analysis.
RESULTSBoth UT-A1 and UT-B1 proteins were expressed in the skin basal cell layer, eccrine sweat gland and apocrine sweat gland tissues. In uremic patients, N-UT-A1 and UT-B1 expressions were significantly higher than those in the control (P<0.05) but C-UT-A1 expression was similar (P>0.05).
CONCLUSIONUTs are expressed in human skin basal cell layer, eccrine sweat gland and apocrine sweat gland tissues, and their expressions are upregulated in uremic patients.
Case-Control Studies ; Humans ; Membrane Transport Proteins ; metabolism ; Sweat Glands ; cytology ; metabolism ; Uremia ; metabolism