1.Late presentation of ALCAPA syndrome in an elderly Asian lady
Kuan Leong Yew ; Zarrin Kang ; Ainaa Anum
The Medical Journal of Malaysia 2016;71(4):217-219
Coronary artery anomalies are often discovered incidentally
during cardiac catheterization or computed tomography
coronary angiography and may involve the affected
coronary artery origin and its course. Coronary artery
anomalies are associated with congenital heart disease. The
affected coronary arteries may have an unusual high take off
origin, origin from contralateral or non-coronary sinus,
origin from the pulmonary artery, single coronary system or
coronary artery fistula.
Bland White Garland Syndrome
2.The Effect of Piper betle on Wound Healing in Male Sprague Dawley
Nur Ain J ; Ainaa Diyana S ; Nur Hazirah R ; Nur Fathiah AS ; Fairus A ; Teoh SL ; Yasmin Anum MY
Medicine and Health 2018;13(1):165-174
Long term glucocorticoids administration induces oxidative stress which leads to alteration of bone structure and strength. Palm oil is rich in tocotrienol, an antioxidant. It can be used for the prevention of oxidative stress related diseases. The main objective of this study was to determine the mechanism of palm tocotrienol in maintaining the bone structure and strength in glucocorticoid-induced osteoporosis. Thirty two adult male Sprague-Dawley rats, aged 3 months, weighing 300-320 g rats were used in this study. Sixteen rats undergone adrenalectomy and were administered with 120μg/kg/day intramuscular injection of dexamethasone. Eight rats were supplemented with oral palm tocotrienol 60 mg/kg/day (Adrx+Dex+PTT) and the other eight rats were given oral vehicle palm olein 0.1 ml/kg/day (Adrx+Dex). Eight rats underwent sham procedure and were given vehicle palm olein 0.05 ml/kg/day by intramuscularly and oral 0.1 ml/kg/day (Sham). The rats were euthanized after two months of treatments. Eight rats were euthanized after acclimatic action without receiving any treatment (Baseline). The right femurs were used for bone biomechanical strength and histomorphometry analysis while the left for gene expression and oxidative stress enzymes activities. The results indicated that long-term glucocorticoid treatment significantly increased bone resorption marker, CTX (6060.7 ± 410 pg/ml) and decreased bone structure and strength. Osteoblast and osteoclast related genes expressions indicated an increase in bone turnover. Supplementation of palm tocotrienol had maintained serum resorption (2619.4 + 209 pg/ml) marker level and preserved bone structure and strength. Gene expression analysis showed decrease in bone resorption. The findings suggested that palm tocotrienol has potential benefits against glucocorticoid-induced osteoporosis by regulating osteoblast and osteoclast related gene expression