Introduction: Pursuing higher education has always been considered to be stressful as students need to adapt to new social and academic environment. Higher education in recent years has shifted from teacher centred authoritarian approach to student centred learning with amicable learning environment. In this changing scenario, this study aims to identify the indicators of stress and stress levels among 21st century university students and fathom the demographic factors influencing it. Method: A cross-sectional survey was conducted on students attending a private university in Malaysia using Stress Indicators Questionnaire. The data was analysed with descriptive and inferential statistical tests. Results: A total of 1050 university students aged between 18-30 years from different faculties voluntarily participated in the study. All respondents reported stress varying from very low to dangerous levels. Among the indicators of stress, sleep and emotional indicators were at dangerous levels, physical indicators and personal habits were at high level and behaviour indicators were perceived at medium level. A significant difference in total stress score between students of different age groups and ethnicity were observed, while no significant difference was noted with regards to gender. Conclusion: This study reveals that various indicators of stress are prevalent among the present-day university students. It may help guide policy makers and teachers in early identification of stress among their pupils and plan effective strategies aimed at balancing a good quality of life and academic achievement for the learners in institutions of higher learning.