Sinonasal undifferentiated carcinoma happens rarely, the clinical manifestations of the disease lacked specificity, with nasal obstruction and blood mainly in a unilateral nasal cavity. Two casas were reviewed, one case of tumor located in the middle of inferior turbinate; 1 in the bottom wall of the anterior nasal cavity. The tumor appeared dark red and unsmooth surface. Sinus CT scan showed occupying shadow and significant bone de struction. Complete resection of the lesion was performed. The pathology of neoplasm showed small-medium sized oval nuclei, high nucleus to cytoplasm ratio, and active mitosis. The pathological diagnosis was undifferentiated carcinoma. Comprehensive treatment of postoperative radiotherapy and chemotherapy were given distant metastasis still happened. One survived in 2 years of follow-up, 1 patient died in 18 months.
Aged ; Carcinoma ; Humans ; Male ; Middle Aged ; Nasal Cavity ; Nose Neoplasms

Management of acetabular deficiency in revision of hip arthroplasty can be extremely challenging. A successful outcome requires careful preoperative planning, identification of complex defects, and stable reconstruction. Now, acetabular reconstructions that are conducted with autograft and allograft filling the defect and special techniques are effective. As more revisions of total hip arthroplasty take place in clinic, a systematic approach to diagnosis and treatment becomes more important. This paper reviews the progress made in classification and reconstruction of acetabular defects.

Objective To analyze the risk factors for venous thromboembolism(VTE) in hospitalized patients undergoing to‐tal hip arthroplasty (THA) or total knee arthroplasty (TKA) at the perioperative period .Methods One hundred and seventy‐four in hospitalized patients who was given THA or TKA from October 2012 to July 2013 were enrolled in this prospective cohort stud‐y .There are a total of 205 cases of surgery ,including 132 T HAs in 122 patients and 73 TKAs in 52 patients .All patients were given Color Doppler Ultrasonography of lower limbs to detect DVT in 3 to 5 days after operation and preoperative .Then the patients were divided into two groups ,the DVT group and the non DVT group according the Ultrasonography results .More than ten factors such as age ,gender ,hypertension in DVT formation were detected .Then their correlation was analyzed .The key influencing factors for DVT were selected .Results Forty‐three patients developed DVT after operation ,the incidence of DVT was 24 .7% .Age≥ 70 years ,rheumatoid and relatively lower PT‐INR before surgery has a statistical significance (P<0 .05);elevated plasma D‐dimer val‐ue before surgery and general anesthesia has a highly statistical significance (P<0 .01) .A preoperative plasma D‐dimer cutoff value as a diagnostic test was calculated as 764 μg/L .Conclusion Age≥70 years old ,relatively lower PT INR ,preoperative elevated plasma D‐dimer value ,rheumatoid and general anesthesia were the risk factors for DVT formation after THA or TKA .A preopera‐tive plasma D‐dimer cutoff value as a diagnostic test was obtained as 764 μg/L .

Objective To observe the effect of ankle slow lengthening fusion on old ankle injury .Methods Totally 3 cases of old ankle injury ,were retrospectively analyzed .The new method of ankle slow lengthening fusion was adopted for conducting treat‐ment .Intraoperative ankle osteotomy and Orthofix external fixation were performed ,ankle slow lengthening was started on postop‐erative 7 d ,and the ankle joint gap was pulled for 1-2 cm ,the double lower limbs were basically equal length and the ankle reached completely bony fusion ,the external fixator was taken out and then weight‐bearing walking started .Results The 10 -23 months follow up was performed ,averaged 16 months .Three cases of ankle joint obtained bony fusion in postoperative 9 months and the ex‐ternal fixator was dismantled .By adopting the AOFAS foot score ,the average score in 3 feet was increased from preoperative 25 .6 points to postoperative 76 .3 points at the time of follow‐up .Conclusion Ankle slow lengthening fusion is an effective treatment method for old ankle joint injury .

Objective To investigate the level of coronary endothelial injury and dysfunction, the jeopardy score of coronary artery lesion by angiography, and their correlations in patients with stable angina (SA) or unstable angina (UA). Methods The 20 patients with UA, 17 patients with SA and 18 patients excluding coronary heart disease (control) were studied. Blood samples were collected during percutaneous coronary intervention (PCI). To investigate the coronary endothelial injury and dysfunction, we measured the concentrations of nitric oxide (NO)? endothelin (ET) and the number of circulating endothelial cells (CEC) in coronary sinus blood. The jeopardy score for coronary artery lesion was evaluated according to the method by Califf. Results In angina patients, especially in UA patients, NO concentration in coronary sinus blood was lower, while ET concentration and CEC number were markedly higher than those in control group. The jeopardy scores showed no difference between UA and SA. The coronary endothelial injury and dysfunction showed a positive correlation with jeopardy scores. Conclusion The coronary endothelial injury and dysfunction is not only the initiation factor, but may play a key role in the progression of atherosclerosis and coronary heart disease. Coronary angiography combined with detection of coronary endothelial injury and dysfunction may better describe the lesion of coronary artery, and evaluate the prognosis of patients with coronary heart disease.

Objective To explore the efficacy of endoscopic surgery for juvenile nasopharyngeal angiofibroma.MethodsDuring 27 years from March 1980 to July 2007,we performed endoscopic surgery on totally 19 patients with nasopharyngeal angiofibromas.According to Radkowski Stating,five of the patients were stage ⅠA,ten were stage ⅠB,and 4 were stage ⅡA.Before the endoscopy,superselective embolization was performed in all the cases via bilateral maxillary arteries.Results All tumors were successfully resected by endoscopy.The intraoperative blood loss was 200-600 ml.One of the stageⅡA patient developed cerebrospinal rhinorrhea during the endoscopic resection,and thus received repair of the middle turbinate by a mucosal patch immediately.In this series of patients,no massive epistaxis,intracerebral infection,or blindness occurred.Follow-up at three months after the surgery by nasoscopy showed epithelialisation of the nasal mucous membrane without residual tumor tissues.Meanwhile,otoscopy revealed normal light reflex of the eardrum,no fluid in the middle ear.Of the patients,eleven were followed up for one to five years,during which none of them had recurrent tumors confirmed by nasoscopy or CT scan.Conclusions Endoscopic resection of nasopharyngeal angiofibroma results in little trauma and few blood loss after superselective embolization.Experience and surgical skills are key points for the operation.

Objective To develop integrative Medical Video Network Real-time Communication System based on hospital LAN.Methods According to the practical features in clinical application and the design principles of miniaturization and low power waste,SOPC software and hardware design technologies were utilized to design the system hardware,which mainly includes such 5 function modules as A/D conversion,automatic selection of digital interface,video codec,CPU and system control.The system control software,including transmission module,interception module and control module,was designed under embedded system.Results The integrative Medical Video Network Real-time Communication System based on hospital LAN could encode and decode medical video in real-time,and the transmission and reception parts could automatic position without manual setting,thus facilitating network real-time transmission of clinical medical video.Conclusion Completely meeting the requirement of medical video real-time transmission in hospital scientific research,teaching and academic exchanges,Medical Video Network Real-time Communication System supports hospital scientific research and teaching greatly.

Objective To explore the influence of IFN-? on anti-proliferation and apoptosis of the Caspase-8 silenced neuroblastoma cell line induced by doxorubicin and the influence mechanism.Methods MTT and flow cytometric analysis were used to detect the survival and apoptosis rates before and after the combined treatment of IFN-? and doxorubicin.Immunohistochemical staining was used to detect the expression of caspase-8 protein before and after the treatment of IFN-?.Results The survival rates of doxorubicin(0.03,0.10,0.30?g/ml)used alone for 24h were(95.62?13.03)%,(82.62?7.94)%,(64.84?9.19)%,IFN-?(10,100,1000U/ml)used alone for 48h were(98.37%?11.25)%,(97.15?5.36)%,(98.84?7.41)%.The survival rates of IFN-?(1000U/ml)combined with different concentration of doxorubicin(0.03,0.10,0.30?g/ml)were significantly lower than that of doxorubicin(0.03,0.10,0.30?g/ml)alone.The apoptosis rate of doxorubicin(0.30?g/ml)alone was(22.00?6.55)%,IFN-?(1000U/ml)alone was (8.22?4.00)%,whereas the apoptosis rate of the combined treatment of IFN-? and doxorubicin wassignificantly higher than that of doxorubicin alone;Immunohistochemical staining showed that caspase-8 protein was negative in SH-SY5Y cell line,whereas it become positiveafter the treatment of IFN-?(1000U/ml)for 48h.Conclusion Treating human neuroblastoma cell line SH-SY5Y cell with doxorubicin may induce anti-proliferation and apoptosis.Combined treatment with IFN-? may significantly increase this effect.The mechanism may be realized by upregulating the expression of caspase-8 protein.

Objective By selecting the prescriptions of treating blood group incompatibility in modern literature, and exploring their regularity, to establish the overall thought of traditional Chinese medicine in treatment.Methods 90 articles on maternal-fetal blood group incompatibility were found.Statistical methods were adopted to summarize high frequently used medicines and formula. Results High frequently used medicines were Virgate Wormwood Herb, Baical Skullcap Root, Rhubarb, Cape Jasmine Fruit, White peony Alba, Chinese Angelica,Largehead Atractylodes Rhizome,Motherwort Herb,and Milkvetch Root, which were mentioned for 238 times in the literatures, occupying 72.79% of the total frequency. Conclusion Based on this result,heat-clearing and dampness-removing, activating blood circulation to eliminate blood stasis was setup as the principle for treating this disease.

Objective To study the role of activated microglia transplantation in recovery of hindlimb locomotor function in rats with spinal cord injury(SCI). Methods A total of 40 female adult Wistar rats were selected and divided into four groups randomly(10 rats in each group).The former two groups were locomotor function observation groups,in which rat model with spinal cord was established by striking with improved self-made Allen's strike equipment to fabricate moderate spinal cord injury and divided into transplantation group and control group.The latter two were histological observation groups,the spinal cord injury model was fabricated by the same above-mentioned method and divided into transplantation and control groups.Before fabricating the spinal cord injury model,the microglia of the newborn rats were cultured,separated,purified and identified and the purity of the microglia determined.The injury position was exposed again seven days after transplantation and the cell suspension of microglia was injected around the injury position with microsyringe,which was free in the control group.The hindlimb locomotor function of rats was detected and scored at 1 day,1,2,3 and 4 weeks in the locomotor function observation groups after transplantation respectively.At the same time,two rats were extracted randomly from the control group and the transplantation group in histological observation groups to cut specimen and slice for Naoumenko-Feign paraffin section and dying.Then,the microglia were observed and counted by microscope and analyzed statistically. Results At 1,2,3 and 4 weeks after operation,the BBB score of the control group and the transplantation group was increased gradually with the time.But compared with the control group,transplantation group had higher scores of hindlimb locomotor function at 2,3 and 4 weeks after operation,with statistical difference(P＜0.05).Naoumenko-Feigin paraffin section and dying and microglia counting showed that positive microglia number in the transplantation group was increased more obviously than the control group,with statistical difference(P＜0.05).Conclusion Activated microglia transplantation can promote the recovery of the hindlimb locomotor function in SCI rats.