Objective To explore the correlative factors of mental disorder in patients with head injury. Methods 255 subjects sustained with head injury and survived from traffic accident in Chengdu were assessed with Structured Clinical Interview for DSM-Ⅳ axis Ⅰ disorders (SCID-I/P) , Personality Disorder Questionaire for CCMD-2-R(PDQC), Structured Clinical Interview for CCMD-2-R(SCICP), WAIS-RC, WMS, brain electric activity mapping (BEAM) after completion of clinical management. Based on the diagnostic criteria of organic mental disorder in CCMD-3, mental disorders in 255 subjects were diagnosed. Results The incidence of mental disorders in the patients with head injury was 72.5% (185/255). Mental disorders in patients with head injury were correlated with educational level, type and severity of the head injury, or injuries involving the left frontal lobe injury, the left temporal lobe or multiple lobes and BEAM abnormality. Conclusion The incidence of mental disorder is high in the patients with head injury. Educational level, type and severity of the head injury, the location of the injured brain, injury involving multiple lobes of the brain may affect morbidity of mental disorders in patients with head injury.

Objective To investigate the effect of dapagliflozin on vascular function and progres-sion of renal function in patients with diabetic nephropathy(DN).Methods A total of 122 DN patients were randomly divided into control group and observation group,with 61 cases in each group.The control group received conventional treatment,while the observation group received conventional treatment and dapagliflozin.Glycometabolism,vascular function,renal function indicators and adverse reactions were compared between the two groups.Results After treatment,there were no significant differences in fasting plasma glucose(FPG)and 2-hour postprandial glucose(2 hPG)between the two groups(P＞0.05),but the glycosylated hemoglobin(HbA1c)level in the observation group was sig-nificantly lower than that in the control group(P＜0.05).The flow-mediated dilation(FMD)for 1 minute at resting state and FMD for 5 minutes at ischemia state were significantly higher in the observa-tion group than those in the control group(P＜0.05);the estimated glomerular filtration rate(eGFR)and 24-hour urinary sodium level in the observation group were significantly higher than those in the control group,while the 24-hour urine protein level was significantly lower than that in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Dapagliflozin can effectively alleviate vascular function damage and inhibit the progression of renal function damage in DN patients.

Objective To investigate the effect of dapagliflozin on vascular function and progres-sion of renal function in patients with diabetic nephropathy(DN).Methods A total of 122 DN patients were randomly divided into control group and observation group,with 61 cases in each group.The control group received conventional treatment,while the observation group received conventional treatment and dapagliflozin.Glycometabolism,vascular function,renal function indicators and adverse reactions were compared between the two groups.Results After treatment,there were no significant differences in fasting plasma glucose(FPG)and 2-hour postprandial glucose(2 hPG)between the two groups(P＞0.05),but the glycosylated hemoglobin(HbA1c)level in the observation group was sig-nificantly lower than that in the control group(P＜0.05).The flow-mediated dilation(FMD)for 1 minute at resting state and FMD for 5 minutes at ischemia state were significantly higher in the observa-tion group than those in the control group(P＜0.05);the estimated glomerular filtration rate(eGFR)and 24-hour urinary sodium level in the observation group were significantly higher than those in the control group,while the 24-hour urine protein level was significantly lower than that in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Dapagliflozin can effectively alleviate vascular function damage and inhibit the progression of renal function damage in DN patients.