Objective To get more understanding on the symptom,and laboratory characteristics of nonsecretory myeloma(NSM).Methods 11 patients with NSM were examined by immunoglobulins IgG,IgA,IgM,IgD,IgE and their light chains,electrophoresis(PE),immunofixation electrophoresis(IFE)and serum free light chain(FLC).Results All 11 patients had more serious bone pains.all had osteolytic bone lesions.All patients were negative in PE,IFE,urine FLC tests.2 newly diagnosed patients had increased serum FLC,abnormal k/λ ratio.1 patient had normal serum FLC and normal k/λ ratio.All 11 patients had more than 30%bone marrow plasma cells.Their overall survivals were same with the typical multiple myeloma(MM).Conclusion Most NSM have more serious bone pains,and osteolytic bone lesions.PE,IFE,urine FLC tests are negative.Newly diagnosed or refractory patients have increased serum FLC,abnormal k/λ ratio,plateau phase patients have normal or reduced serum FLC.Most NSM have more than 30%bone marrow plasma cells.The therapy and prognosis of NSM are same with typical MM.

The paper conducted a descriptive analysis of the current situation of the faculty in the School of the Traditional Chinese Medicine of Capital Medical University.Then,using the framework of SWOT analysis,the paper discussed the external and internal factors related with the faculty development.According to the suggestions collected via expert consultation,strategies for the faculty development were put forward in the last part of the paper.

MicroRNA (miRNA) is a class of endogenous,single-stranded non-coding small RNA that contains 21 to 23 nucleotides and is widely distributed in eucaryon,miRNA plays an important regulatory role in cell proliferation,apoptosis,growth and development through the regulation of gene translation after transcription and expression,miRNA has a close relationship with pathogenesis and development of hepatocellular carcinoma.And in this process,part of miRNA acts as oncogenes or tumor suppressor genes.A number of miRNA,such as miR-30d,miR-221,miR-222 and miR-101,had been found to express abnormally in hepatoeellular carcinoma.Here we summarize the related progress in research of miRNA and hepatocellular carcinoma.

Multiple myeloma is one of the common hematological malignant disease,but the treatment response was not very promising with conventional and high-dose chemotherapy.There are many new medicines or new therapies having been developed in recent years,such as thalidomide and its derivant,proteasome inhibitors,arsenic trioxide etc,they are more effective than conventional chemotherapy,such as oral melphalan and prednisone(MP);vincristine,doxorubicin,and dexamethasone(VAD).This paper summarize the recent advances in the new options for the treatment of multiple myeloma

Objective To make an assessment method for the efficiency of spraying air cleaning products used in the indoor air. Methods 1.5 m3 chamber was used, the temperature was (21?2.5) ℃ and the relative humidity was (40?5)%. The formaldehyde of 10 times of the standard limit was added in the chamber, then the products were sprayed, the air cleaning efficiency was assessed at different times. Results The polluted indoor air by formaldehyde could be purified by air the cleaning products, the CADRq≥2.0?10-2 m3/(min?g) within 60 min. Conclusion The assessment method is accurate and applicable to the assessment of efficiency of spraying air cleaning products used in the indoor air cleaning.

Objective To study the expression of E-cadherin and ?-catenin in endometrial and endometriotic tissues of patients with endometriosis (EM) and to compare their expression in endometriosis at different stages. Methods Twenty-four EM patients were enrolled and the expression of E-cadherin and ?-catenin in endometrial and endometriotic tissues were determined by immunohistochemistry method. Normal endometrial tissue from 21 individuals was included as the control group. Results Compared with the control group, in E-cadherin and ?-catenin expression was shown in no difference between the secretory and the proliferative phase of endometrial tissue from EM patients. Furthermore, the expressions of E-cadherin and ?-catenin in normal endometrial tissue were stronger than that of EM patients(P

Objective Exploration of best effect on washing medical instrument between automatic cleaning sterilizer and ultrasonic cleaners.Methods Suppose washing method A and method B.A:directly put medical instrument into automatic cleaning sterilizer,wash,sterilize and dry it step by step.B:place medical instrument into ultrasonic cleaners,wash with ultra sonic,shower with cool water,sterilize and dry with hot water.Results By comparison,after washing method A,there remains 0.33‰ residue on the medical instrument while after B there are 0.03‰ remains.It has an evident difference between result of the two methods(?~2=46.546,P=0.000).Especially on the cleaning result of saw-shaped medical instrument:A method has 0.52‰ residue while method B is 0.04‰,which is of great significance.But there exists no significant difference of washing result on non saw-shaped instrument(?~2=2.667,P=0.102).Conclusion Ultrasonic cleaners can reach the optimum washing effect on saw-shaped medical instrument,with a great decline on residue after cleaning.And automatic cleaning sterilizer can wash large quantity of non saw-shaped,saving labor and enhancing efficiency by automation cleaning process.Therefore,adpoting different equipment to wash different instrument can efficiently improve cleaning effect and ensure safe and qualified stelization.

The paper analyzed the experiences of clinical subjects development at hospitals of Capital Medical University.On this basis,the authors raised such development suggestions as further improvement of the management systems,progressive affiliation mechanism,information platform,and better performance appraisal mechanism,for the purposes of empowering the standard and strength of clinical subjects of the hospitals.

Objective:To detect the expression of ALDH1 and ABCG2 in the specimens from different levels of cervical lesions.Methods:Use SP immunohistochemistry to detect the expression of ALDH1 and ABCG2 in 76 cases of cervical squamous cancers,52 cases of HSIL,and 37 cases of chronic cervicitis tissues,and analyze the results.Results:①The positive expression rates of ALDH1 and ABCG2 in chronic cervicitis tissues were 5.41％ (2/37) and 8.11％ (3/37),in HSIL tissues were 23.08％ (12/52) and 28.85％ (15/52),and in cervical cancers tissues were 53.95％ (41/76) and 61.84％ (47/76),respectively.The positive expression rates in cervical cancers tissues were significantly higher than in HSIL and Cc hronic cervicitis tissues,(P ＜ 0.05).②The positive expression of ALDH1 in cervical cancer tissues had correlation with tumor grade and lymphnode metastasis (P ＜0.05),while the positive expression of ABCG2 in cervical cancer tissues had correlation with tumor grade,clinical stage and lymph-node metastasis(P ＜0.05).③The expressions of ALDH1 and ARCG2 in cervical cancer were positive relative(r =0.535,P ＜ 0.05).Conclusions:The increased expressions of ALDH1 and ABCG2 in cervical squamous cancer may play a role in the occurrence,development and metastasis of cervical squamous cell carcinoma.ALDH1 and ABCG2 may have synergistic effect in occurrence of cervical cancer.

OBJECTIVE:To prepare clobetasol propionate gel and to establish a method for its quality control METHODS:With carbamer941 as veihele,the 0 05% clobetasol propionate gel was prepared;An ultraviolet spectrophotometry at 241nm for the determination of clobetasol propionate in gel was established RESULTS:The calibration curve of clobetasol propionate was linear in the concentration range of 6～24?g/ml,A=0 0 324C-0 0 863(n=3),r=0 9 999 The average recovery rate was 99 44%(n=5),RSD=1 14% CONCLUSION:The preparation of clobetasol propionate gel was simple,its quality was stable;The method of quality control was rapid and accurate