Objective To investigate the effect of ceftidine in operating room intervention and its effect on the quality of intervention. Methods Select 2016 May to May 2017, hangzhou normal university affiliated hospital operating room of our hospital, 366 cases of patients with skull, 2 groups randomly divided into two groups, control group routine surgery, the team combined use of cephalosporins he totally, compared two groups of two groups patients therapeutic effect. Results The intracranial infection was significantly lower in the two groups than in the control group (P<0.05). In the two groups, the number of live bacteria and the comparison of enzyme value were significantly lower than that in the control group (P <0.05). Intervention quality compared two groups of 2 groups of patients, the team of PCT in patients with calcitonin (former) and CRP (CRP), TNF alpha (tumor necrosis factor alpha) and white blood cell count were significantly lower than control group (P< 0.05). Conclusion Children with oral ulcer treatment, the therapeutic effect of smecta ideal, clinical application shall be the head to prevent the use of cephalosporins in patients with surgical intervention in the operating room he totally, can improve the quality of intervention, reduce the incidence of infection.