Objective To evaluate the safety and feasibility of the implication of Cypher~(TM) drug-eluting stent in primary PTCA of acute myocardial infarction.Methods From November,2002 to November,2004,77cases of acute myocardial infarction patients enrolled into our hospital were treated by PCI within 12 hours after the heart attack.All patients were divided into two groups:Cypher~(TM) drug-eluting stent group(38) and conventional stainless steel stent group(39).Results The success rate of PCI were 100% in either group.38 Cypher~(TM) drug-eluting stent and 39 conventional stainless steel stent were implanted respectively.There was no significant difference in CAG result or clinical state among these two groups.Conclusion Cypher~(TM) drug-eluting stent can be safely and efficiently used in patients with acute myocardial infarction.

Objective To explore the influence of macrophage migration inhibitory factor (MIF)on signal transmit route of collagen synthesis in vascular smooth muscle cell (SMC).Methods The expression of signal transmit phosphorylated ERK of SMC in the rat aorta was measured by the western blotting procession after stimulation by MIF,Ang Ⅱ,MIF +PD 98059,AngⅡ +PD 98059. Results The expression of phosphate ERK of the SMC raised significantly after MIF and Ang Ⅱ stim-ulation (P <0.05).The mount of phosphorylated ERK in the Ang Ⅱ group was higher than that in the MIF group.After adding PD 98059,the phosphorylated ERK in both groups decreased significantly (P <0.05).Conclusion Both MIF and Ang II can activate MAPK/ERK route,and it might act in the same signal transmit route of collagen synthesis between MIF effect and Ang II effect.

Objective To explore the influence of macrophage migration inhibitory factor (MIF)on signal transmit route of collagen synthesis in vascular smooth muscle cell (SMC).Methods The expression of signal transmit phosphorylated ERK of SMC in the rat aorta was measured by the western blotting procession after stimulation by MIF,Ang Ⅱ,MIF +PD 98059,AngⅡ +PD 98059. Results The expression of phosphate ERK of the SMC raised significantly after MIF and Ang Ⅱ stim-ulation (P <0.05).The mount of phosphorylated ERK in the Ang Ⅱ group was higher than that in the MIF group.After adding PD 98059,the phosphorylated ERK in both groups decreased significantly (P <0.05).Conclusion Both MIF and Ang II can activate MAPK/ERK route,and it might act in the same signal transmit route of collagen synthesis between MIF effect and Ang II effect.