Objective To identify the posttraumatic growth (PTG) level of cancer patients and to examine the effects of rumination on posttraumatic growth of cancer patients.Methods A total of 312 cancer patients were recruited by convenience sampling.A cross-sectional study was conducted in cancer patient by means of questionnaires that included demographic scale,Event Related Rumination Inventory and the Posttraumatic Growth Inventory (PTGI).Results A total score of event-related rumination in cancer patients was 25.13±11.11,and the total score of posttraumatic growth was 67,21±14.66.The PTG was positively correlated to event-related rumination in cancer patients (r=0.384,P ＜ 0.01).Multiple stepwise regressions indicated that the variables of deliberate of rumination,gender,age,degree of psychological distress,intrusive rumination and education level were main predictors of PTG.Among those deliberate of rumination positively predicts PTG,while intrusive rumination negatively predicts PTG.The level of PTG in female gender cancer patients were higher than male patients,younger age and high education level,less psychological distress patients related to higher PTG.Conclusions Cancer patients reported a lower level of rumination and PTG.Clinical healthcare providers should inspire and promote cancer patients' deliberate rumination,decrease their intrusive rumination,pay attention to male,more psychological distress,older age and lower education level patients,in order to facilitate patients' PTG and then improve their quality of life.

Objective:To explore the impact of cognitive evaluation, processing and social support on post-traumatic growth of patients with accidental trauma, and analyzed their impact path.Methods:Cognitive evaluation scale, event-related rumination meditation scale, social support scale and Chinese version of post-traumatic growth questionnaire were used to conduct a cross-sectional survey on 336 patients with accidental trauma.Results:The total score of post-traumatic growth (PTG) of patients with accidental trauma (58.74±13.53) and the total score of purposeful rumination and total rumination were positively correlated with the total score of post-traumatic growth and all dimensions ( r=0.578, 0.439, P<0.01); the total score of invasive rumination was negatively correlated with the total post-traumatic growth score ( r=-0.144, P<0.01); the social support was positively correlated with the total post-traumatic growth score ( r=0.492, P<0.01). Positive cognitive evaluation and purposeful rumination meditation played a partial mediating role between social support and post-traumatic growth. The mediating effect was 0.142, accounting for 13% of the total effect. Conclusion:Social support not only directly predicted the post-traumatic growth, but also indirectly affected the post-traumatic growth through social support positive cognitive evaluation, and purposeful rumination.

Objective To research the method for constructing an ECG acquisition platform on Zigbee based network with multi-node. Methods The platform is based on an SOC Zigbee chip CC2430. Furthermore,the hardware design and software ECG sampling process is introduced respectively. Results As the Zigbee can support dynamic routing on the platform,we can get ECG data in abundance,and meanwhile,users get more room and freedom. Conclusion It's a right nice scheme for colleting ECG data.

Objective:To explore the effects of formative assessment using sitcom play in obstetrics and gyne-cology nursing teaching.Methods:Totally 214 undergraduate of grade 2011 nursing students were recruited in the present study.Using envelope method,2 classes were randomly selected as the control group and 2 as the experi-mental group.Students in the control group (n--107) were assessed with traditional assessment method,while those in the experimental group (n =107) were taught using situational drama performance and assessed with form-ative assessment method throughout the process.Students' test scores of obstetrics and gynecology nursing in these two groups were compared,and the opinions on the formative assessment method using sitcom play were investiga-ted among students in the experimental group.Results:Students in the experimental groupscored significantly high-er than those of the control group(78.43 ± 5.21 vs.76.67 ± 6.40,t =2.20,P ＜ 0.05).About 98.31％ of the students approved the formative assessment mode.They reported that this approach was helpful to improve the abili-ty to combine theory and practice andto communicate with others,to cultivate students' creative thinking,and to stimulate their learning interest and learning initiative.Conclusion:The application of formative assessment mode using sitcom play in obstetrics and gynecology nursing teaching is beneficial to enhance teaching effect and improve the ability of nursing students,which is worth popularizing.

12 cases of human placentas were obtained after administration of Chinese medicinal herb (Chuan-Xin-Lian) -induced abortion during mid-pregnancy. Six placentas from curettage induced abortion during mid-pregnancy were used as controls. All the specimens were studied histochemically and immunohistochemically by using antiserum to HCG with PAP method. In most of the specimens from women treated during mid-pregnancy, we observed a decreased immunoreaction of antiserum to HCG and a decrease of RNA content in the syncytiotrophoblasts. Increased activity of acid phosphatase in dccidual cells was observed during mid-pregnancy. These findings indicate that during mid-pregnancy, Chinese medicinal herb (Chuan-Xin-Lian) can reduce the synthesis of HCG in syncytiotrophoblasts and can initiate uterine contractions, so that abortion results. The possibility that the changes of lysosomal enzymes are involved in the initiation of uterine contractions is disscused.

OBJECTIVE To investigate the apoptosis of hepatocytes in arsenic poisoning rats caused by coal-burning and explore the effects of p53-induced mitochondrial apoptotic pathway on arsenic liver injury.METHODS Wistar rats were fed with 164.74 pp m arsenic conta minated grain at the levels of 15%,30% and 60% (arsenic contents were 25,50 and 100 mg·kg -1 ,respectively)for 90 d. The arsenic contents of urine and hair,apoptosis of hepatocytes and mRNA expression of p53,Bax and Bcl2 in peripheral blood and hepatocytes were evaluated.At the sa me ti me,protein expression of p53, Bax and Bcl2 in hepatocytes were analyzed.RESULTS The arsenic contents of urine and hair increased with the elevation of arsenic dose.The apoptotic rate of hepatocytes in arsenic 50 and 100 mg·kg -1 group were 16.49 ±2.06 and 15.83 ±1 .28,respectively which were significantly higher than the control group and arsenic 25 mg·kg -1 group (9.00 ±0.59 and 9.27 ±0.36,respectively,P <0.05).p53 mRNA expression of peripheral blood in arsenic 100 mg·kg -1 group was 2.69 ±1 .84 while p53 mRNA expression of hepatocytes in arsenic 25,50 and 100 mg·kg -1 group were 1 .63 ±0.28, 1 .91 ±0.38 and 1 .71 ±0.18,respectively which were significantly higher than the control group (0.86 ± 0.15 and 1 .22 ±0.12,respectively,P<0.05).Bax mRNA expression of peripheral blood in arsenic 50 and 100 mg·kg -1 group were 1 .36 ±0.30 and 1 .94 ±0.65 while Bax mRNA expression of hepatocytes in arsenic 100 mg·kg -1 group was 1 .34 ±0.23 which were significantly higher than the control group (0.77 ±0.15 and 0.84 ±0.34,respectively,P<0.05).Bcl2 mRNA expression of hepatocytes in arse-nic 100 mg·kg -1 group was 0.98 ±0.50 which was significantly lower than the control group (2.14 ± 1 .15,P<0.05).p53 protein expression of hepatocytes in arsenic 25,50 and 100 mg·kg -1 group were 1 .06 ±0.56,1 .15 ±0.77 and 0.74 ±0.27,respectively while Bax protein expression of hepatocytes in arsenic 50 and 100 mg·kg -1 group were 0.74 ±0.43 and 0.69 ±0.37 which were significantly higher than the control group (0.36 ±0.1 9 and 0.25 ±0.09,respectively,P<0.05).CONCLUSION Arsenic can induce hepatocytes apoptosis and p53-mediated mitochondrial apoptotic pathway may be involved in the develop ment of rat liver injury in arsenic poisoning rats caused by coal-burning.

Aim To observe the effect of Ginkgo biloba extract 50(GBE50)on L-type calcium current and cytosolic[Ca~(2+)]_i in ischemic guinea pig ventricular myocytes.Methods Single ventricular myocytes were isolated by enzymatic dissociation. I Ca-L was recorded by whole-cell patch clamp technique in voltage clamp mode.[Ca~(2+)]_i was detected by laser confocal micros-copy and represented by relative fluorescent intensity (FI).Results During ischemia, the peak Ca~(2+) current was reduced, and the I-U curve of I Ca-L was shifted upward.50 mg·L~(-1) GBE50 reversed the change induced by ischemia(n =6, P >0.05).After perfusing ischemic solution for 12 min, intracellular calcium concentration was increased(n =10, P <0.01).After perfusion with ischemic solution containing 50 mg·L~(-1) GBE50, the increase of intracellular calcium concentration was markedly inhibited(n =10, P >0.05).Conclusion GBE50 can reverse the decrease of I Ca-L and partially inhibit calcium overloading during ischemia.

Endemic arsenicosis is one of the national key endemic diseases in our country. However, due to obscure mechanism of arsenic poisoning, lack of early diagnostic indicators and specific validated therapy, the ideal control of endemic arsenicosis has not yet been obtained. To date, considerable progress has been made to address endemic arsenic poising and also formed various hypotheses, whereas simultaneously there are some problems and the insufficiency such as unclear relationship among those hypotheses and the gap between mechanism studies and translational application. In consequence, enhancing the interactive effects among various mechanisms of arsenic poising and improving its translational application could have more realistic significance for scientific prevention and control of endemic arsenicosis.

Traditional Chinese medicine (TCM) has been used to prevent disease for thousands of years. However, the actual value of TCM has not been recognized adequately due to the lack of scientific approaches to its study . Fortunately, metabolomics becomes practically available and consists with the holistic thinking of TCM. The metabolomics can serve as a new strategy for evaluating the efficacy of TCM . This review summarized applications of metabolomics in special TCM field with an emphasis on biomarker discovery.

In recent years,the influence of endemic arsenic poisoning on immune system has caught people's attention.Changes in histone modification patterns may be one of the mechanisms of arsenic regulated gene expression,arsenic plays an important role in differentiation,proliferation and function of immune cells.Arsenic has a certain effect on the differentiation and function of T cells,and it is rarely studied whether the process is regulated by histone methylation.In this paper,the study of histone methylation in arsenic induced T cellular immune damage is reviewed.