Objective Observe the effect of simple closure for the treatment of perforated duodenal ulcers and the efficacy of laparoscopic repair in the condition of modern medical treatment.Methods 65 cases with duodenal ulcer perforation were operated on simple closure with open or laparoscopy.All patients were received triple therapy of lansoprasole 30 mg qd+am oxycillin 1g bid+furazolidone 0.1 g tid for a week and were followed up for 3～31 months.Results The ulcer cure rate was 96.9% after the triple therapy had been finished for one month.Postoperatevely,the ulcer recurrence rates within one and two years were 4.2% and 5.9%.No one was reoperated because of ulcer recurrence.The length of hospital stay had a very significant difference between open operation group and laparoscopy group.Conclusion The operation of simple closure,especially laparoscopic repair is simple and safe,and should has a priority to treat perforated duodenal ulcers.