2.One case with first seizure showing status epilepticus.
Chinese Journal of Pediatrics 2003;41(6):478-478
Child
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Electroencephalography
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Humans
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Male
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Seizures
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diagnosis
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Status Epilepticus
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diagnosis
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Time Factors
6.The study on plasma concentration of high-dose methotrexate chemotherapy for children with acute lymphoblastic leukemia
Ai-dong, LU ; Le-ping, ZHANG ; Gui-lan, LIU
Journal of Applied Clinical Pediatrics 1986;0(01):-
Objective To investigate the relationship among methotrexate(MTX) plasma concentration,dosage,clinical effecicy and toxicity, and to evaluate it′s clinical significance.Methods MTX was measured by a flurorescence polarization immunoassay in plasma samples obtained from acute lymphoblastic leukemia(ALL) patients treated in different doses of MTX, and these results were analyzed combined with clinical manifestations.Results 1.The average of plasma concentration at 24 hours increased with the increasing doses of MTX. The relapse rate decreased with increased plasma concentration;2.The cerebrospinal fluid(CSF) concentrations prior to the intrathecal MTXinstillation were all below the effective concentration, so the intrathecal MTX instillation was needed;3.No severe toxicity was observed in the study, because the plasma concentration was below the high risk.Conclusion The study of MTX plasma concentration provides us an objective basis for the individualized chemotherapy.
7.Significance of Changes of Plasma Levels of Adrenomedullin and Endothelin-1 in Infants with Congenital Heart Disease Complicated with Congestive Heart Failure
ming, LU ; ai-hua, GUO ; yi, WU ; chun-ping, XU
Journal of Applied Clinical Pediatrics 1986;0(01):-
Objective To investigate the roles of adrenomedullin(ADM) and endothelin-1(ET-1) in left-to-right shunt congenital heart disease(CHD) complicated with congestive heart failure(CHF).Methods Plasma ADM and ET-1 concentrations were measured by radioimmunoassay in heart failure stage and recovery period of 18 infants with left-to-right shunt CHD.Also 20 healthy infants acted as control group were measured.Results Plasma concentrations of ADM and EF-1 were significantly higher in heart failure stage of left-to-right CHD infants than those in their recovery period,and both in their heart failure stage and in their recovery period were higher than that in control group(P