1.A case of agranulocytosis following psychotropic agent therapy.
Journal of Korean Neuropsychiatric Association 1993;32(4):589-593
No abstract available.
Agranulocytosis*
2.The effect of granulocyte colony stimulating facto(G-CSF) in a patient with propylthiouracil-induced agranulocytosis.
Kwang Hyen YOU ; Seung Si SON ; Seung Yel SONG ; Myoung Seon PARK ; Yong Gu LEE ; Chung Gu CHO
Journal of Korean Society of Endocrinology 1993;8(3):347-350
No abstract available.
Agranulocytosis*
;
Granulocytes*
;
Humans
3.Rapid preoperative preparation for thyroidectomy of a severely hyperthyroid patient with Graves’ Disease who developed agranulocytosis
Daveric Pagsisihan ; Aimee Andag-Silva ; Olivia Piores-Roderos ; Ma. Ailsa Escobin
Journal of the ASEAN Federation of Endocrine Societies 2015;30(1):48-52
Preoperative preparation of the hyperthyroid patient for thyroidectomy is imperative to avoid perioperative complications due to severe thyrotoxicosis. The mainstay of preparation is the administration of anti-thyroid drugs (ATD). When ATDs cause adverse reactions, an alternative regimen to prepare the patient for definitive management is crucial. We present the case of a 35-year-old Filipino female with Graves’ disease who developed methimazole-induced agranulocytosis. She refused to undergo radioactive iodine (RAI) therapy. She was admitted for thyroidectomy with elevated thyroid hormone levels. She was rapidly prepared for thyroidectomy using high-dose steroid, beta-adrenergic blocker, propylthiouracil (PTU) and Lugol’s solution. The patient’s free thyroxine level decreased after 8 days of treatment, without complications. She then underwent an uneventful subtotal thyroidectomy. In conditions with very limited options, although contraindicated, administration of another ATD may be the last alternative for patients who developed agranulocytosis.
Hyperthyroidism
;
Thyroidectomy
;
Agranulocytosis
;
Iodine
4.Conversion of primary hypothyroidism to hyperthyroidism: A case report
Journal of the ASEAN Federation of Endocrine Societies 2018;33(2):190-193
A 51-year-old Caucasian male developed Graves’ thyrotoxicosis following long-standing treatment for hypothyroidism. After a short period of treatment with carbimazole, he developed agranulocytosis and required total thyroidectomy. In this relevant case report, we review several pathogenetic mechanisms that explain the transformation of autoimmune hypothyroidism into Graves’ disease and the possible approaches to the management of agranulocytosis secondary to antithyroid medications. Further studies are required to determine the best way to manage severe thyrotoxicosis when agranulocytosis develops due to antithyroid medications.
Hypothyroidism
;
Antithyroid Agents
;
Carbimazole
;
Agranulocytosis
5.A case of Methimazole-Induced Cholestatic Jaundice With Agranulocytosis.
Sang Gu KANG ; Jong Oh BAE ; Eun Young LEE ; Seong Min LIM ; Sang Kun CHO ; Ji Hye KIM ; Sun Kyung SONG
Journal of Korean Society of Endocrinology 2005;20(5):519-523
Methimazole is a widely used and generally well-tolerated antithyroid agent. Adverse reactions occur in 1~5% of patients taking methimazole medication, but these are most commonly transient, benign leukopenia and a skin rash. Severe cholestatic jaundice, combined with agranulocytosis, has been known as a rare complication. Herein, a case of methimazole induced cholestatic jaundice, with agranulocytosis, is reported.
Agranulocytosis*
;
Exanthema
;
Humans
;
Jaundice, Obstructive*
;
Leukopenia
;
Methimazole
6.Two cases of congenital agranulocytosis treated with recombinant human granulocyte colony-stimulating factor.
Byoung Ho CHA ; Seung Hwan OH ; Chukl Joo LYU ; Chang Hyun YANG ; Kir Young KIM
Korean Journal of Hematology 1992;27(2):325-329
No abstract available.
Agranulocytosis*
;
Granulocyte Colony-Stimulating Factor*
;
Granulocytes*
;
Humans*
7.A Case of Clozapine-Induced Eosinophilia Combined with Bilateral Pleural Effusion, Ascites, Cholecysctitis, and Hepatitis.
Hyun Ju HONG ; Chan Hyung KIM ; Dong Ho SONG ; Se Jun LEE ; Hong Shick LEE
Korean Journal of Psychopharmacology 1999;10(2):191-195
Several blood dyscrasias associated with clozapine have been well known to clinicians and potentially life threatening agranulocytosis has been widely reported. However, there is little report regarding incidence, progression and associated features of eosinophilia associated with clozapine. In clinical studies, the onset of eosinophilia usually occurs artier 3 to 5 weeks of treatment and rarely were cases fatal with medical complication. We report the first case of severe eosinophilia, bilateral pleural effusion, asicites, hepatitis and cholecystitis associated with clozapine that would be fatal. Eosinophilia occurred after 19 days of treatment with clozapine and all the clinical conditions improved along with interruption of clozapine treatment. It is suggested that eosinophilia may be more severe side effort than has ether been known and close hematologic monitoring should be done during early treatment of clozapine.
Agranulocytosis
;
Ascites*
;
Cholecystitis
;
Clozapine
;
Eosinophilia*
;
Ether
;
Hepatitis*
;
Incidence
;
Pleural Effusion*
8.Agranulocytosis and Neutropenia in Clozapine-Treated Patients.
Hyun Sang CHO ; Suk Kyoon AN ; Chan Hyung KIM ; Hong Shick LEE
Korean Journal of Psychopharmacology 1999;10(2):166-172
OBJECTIVE: Clozapine is effective in the treatment of refractory schizophrenic patients, but can cause reversible and fatal food dyscrasias. This study documents the incidence of agranulocytosis and neutropenia and the characteristics of patients with clozapine-inducted agranulocytosis. METHOD: An analysis was made of the hematological, demographic, and other characteristics data from Clozaril Patient Monitoring System(CPMS) data on 2139 patients on clozapine over about 3 years in Korea. RESULTS: During the study period, agranulocytosis developed in 11 patients and 9 (81.8%) patients occurred within 18 weeks. The cumulative incidence of this side effect was 0.57% at 6 months and 0.65% at 1 to 3 years and the crude incidence was 0.51%. Neutropenia occurred in 157 patients and 114(72.6%) ones developed within 18 weeks. The crude incidence of this blood abnormality was 6.9% at 1 year and 7.3% at 3 years. The cumulative incidence was 9.0% at 1 year and 28.7% at 3 years. The hazard rates far agranulocytosis and neutropenia peaked during the 3rd month and 2nd month, respectively. CONCLUSIONS: These results showed that the incidence of agranulocytosis in Korea may be lower than in USA and UK, at least during the early years of clozapine marketing. Also those suggest that the CPMS in Korea serves as a effective early warning system to promote the safety and benefits of clozapine.
Agranulocytosis*
;
Clozapine
;
Humans
;
Incidence
;
Korea
;
Marketing
;
Monitoring, Physiologic
;
Neutropenia*
9.Therapeutic Effect of Risperidone on the Refractory Schizophrenia: a Single-Blinded Comparison with Haloperidol.
Kwang Won LEE ; Tae Ho YOON ; Chul LEE ; Ki Yong JANG ; Ki Soo SEONG ; In Jeh SONG
Journal of Korean Neuropsychiatric Association 1998;37(6):1111-1120
OBJECTIVES: We attempted to investigate clinical efficacy of risperidone a new antipsychotic agent with high safety and without life-threatening side effect such as agranulocytosis, in refractory schizophrenia compared with a haloperidol, well-known antipsychotic agent. METHODS: Thirty-four subjects(risperidone group 16, haloperidol group 18), who had been proved to be refractory schizophrenics with prospective antipsychotic treatment with at least 2 antipsychotic agents belonging to different chemical groups from each other, were examined with Clinical Global Impression(CGI) and 18-item Brief Psychiatric Rating Scale(BPRS) at 0, 2nd, 4th, 8th, and 12th week from start of drug administration. Those scales were rated in the single-blind manner. RESULTS: End-point response rate of risperidone was 25%(4 subjects), and that of haloperidol was zero. Difference of the response rates between risperidone and haloperidol was statistically significant. Broader spectrum of symptoms was improved with risperidone treatment than with haloperidol. CONCLUSION: Risperidone is an antipsychotic agent that clinicians can primarily and effectively try in the refractory schizophrenics with high safety.
Agranulocytosis
;
Antipsychotic Agents
;
Haloperidol*
;
Prospective Studies
;
Risperidone*
;
Schizophrenia*
;
Weights and Measures
10.Levamisole-Induced Reversible Agranulocytosis in Children with Steroid Dependent Nephrotic Syndrome.
Su Jin LEE ; Su Ja HWANG ; Eun Seon YOO ; Seung Joo LEE
Journal of the Korean Pediatric Society 1999;42(4):576-579
Levamisole has been used for nephrotic syndrome due to its immunostimulating, immunomodulating, and steroid-sparing effects. Agranulocytosis, a serious side effect of levamisole, was rare and mostly associated with autoimmune disease, neoplastic disease and HLA B27 except one case in a nephrotic syndrome who was treated with high-dose(5mg/kg QOD) levamisole. This 15 year-old girl with steroid dependent nephrotic syndrome, who was negative for HLA B27, was treated with the usual recommended dose of levamisole(2.5mg/kg QOD). She developed agranulocytosis after 5 weeks of therapy and completely recovered in 11 days after discontinuation of levamisole.
Adolescent
;
Agranulocytosis*
;
Autoimmune Diseases
;
Child*
;
Female
;
Humans
;
Levamisole
;
Nephrotic Syndrome*