Administration, Topical ; Humans ; Labyrinth Diseases ; drug therapy

To evaluate effects of the topical administration of non-steroidal antiinflammatory drug on anterior uveitis, suprofen eye drop was instilled into the left eye of 10 pigmented rabbits and then experimental anterior uveitis was induced by injecting 750 mocro gram/kg endotoxin of Shigella flexneri serotype 1A into their peritoneal cavities. The pupillary diameters were measured, and cell and flare gradings were recorded in 20 eyes of 10 rabbits for one week at an interval of 12 hours for the first day and then daily. Differences between the treatment and control groups were investigated. All the above parameters showed greatest changes at 12 or 24 hours after the injection of endotoxin and became normal by one week. The treatment and the control groups demonstrated statistically significant difference at 12 hours, day 1, and day 2 as for pupillary diameter and at day 1 and day 2 as for cell and at 12 hours and day 1 as for flare. Thus, it is concluded that prostaglandin plays a role in miosis and the appearance of inflammatory cells and flare in anterior uveitis and the topical administration of non-steroidal anti-inflammatory drug can alleviate signs of anterior uveitis. The specific relationship between leucotriene B4 and polymorphonuclear leucocytes influx was not demonstrated.
Administration, Topical ; Miosis ; Rabbits ; Shigella flexneri ; Suprofen ; Uveitis, Anterior*

Administration, Topical ; Humans ; Mouth Diseases ; drug therapy ; Mouth Mucosa

Administration, Topical ; Ear, Inner ; pathology ; Humans ; Meniere Disease ; therapy

The outcomes of microvascular surgery may be jeopardized by factors that reduce the blood flow across the freshly the performed anastomosis Arterial vasospasm is one of such factors causing the failure of an anastomosis. Vascular spasm has treated by systemic or topical administration of pharmacologic agents. However, despite the works done to prevent and elucidate the cause of vasospasm, a apasmolytic agent Capable of consistently protecting against it or reversing it has not been found. Vascular freezing as an powerful spasmolytic maneuver has recently been reported. The purpose of the present study was to determine optimal vascular freezing time. The effect of vascular freezing time was examined on the relief of arterial vasospasm. The vascular was freezing was performed on the artery of rats whit hand-held liquid nitrogen oxide spray. the artery was frozen for 5, 15,or 30 seconds. Vascular spasm and patency were evaluated immediately after and 1, 3, 7, 14, and 56 days after the freezing. Femaral arteries were havested at 1, 3, 7, 14, and 56 days after freezing for histologc examination The results obtained were as follows : 1. immediately after the freezing-thawing, the vasospasm was relieved and not induced by spasmogenic induction manipulation in all groups. 2. Immediately after the freezing-thawing, the artery become dialated, the diameter of which was slightly more than the intial, ranging between 0-17% and the diameter of 5-second group was smaller than those of 15-and 30-second group(P<0.05). 3. One to 56 days after freezing, arteral diameter was still 1-22% larger than the initial and there was no significant difference among groups. 4. One to 56 days after the freezing, vasospasm was not induced by spasmogenic induction manipulation in all groups. 5. One day after the freezing, almost all the vessel wall died and the normal architeture of the layer was deranged in all group. The shorter was the duration of freezing, the more early was the healing of artery occurred, 6. Fifty-six days after the freezing, cellularity was increased and the architecture was regenerated, There was no significant differance among groups. It was suggested that vascular freezing for 5 seconds is useful to relieve the vasospasm and to lessen the injury of artery.
Administration, Topical ; Animals ; Arteries ; Freezing* ; Nitrogen ; Rats* ; Spasm

Administration, Topical ; Cariostatic Agents ; administration & dosage ; therapeutic use ; Child ; China ; Dental Caries ; prevention & control ; Fluorides ; administration & dosage ; therapeutic use ; Humans

Administration, Topical ; Cinnamomum zeylanicum ; Episiotomy ; methods ; Female ; Gels ; administration & dosage ; Humans ; Phytotherapy ; methods ; Plant Preparations ; administration & dosage ; Pregnancy

Iododerma is a rare cutaneous eruption that occurs after oral, parenteral or topical administration of iodides. Acneiform papulopustular lesions are the most common skin reactions of iododerma and erythematous, vesiculobullous, vegetative, and pustular psoriasis-like lesions appear less commonly. A 40-year-old woman with post-thyroidectomy presented with pustular and crusted patches with erythematous and indurated bases on the face and well-defined purplish crusted desquamative plaques on the lower legs at 10 days after radioactive iodine-131 ablation. Based on clinicopathological findings and history, she was diagnosed with iododerma following radioactive iodine ablation. Hypersensitivity to iodine is more uncommon in iodine-131 therapy compared with other iodine-containing substances since the quantity of sodium iodide is infinitely small. As iododerma following radioactive iodine ablation is a rare entity, so clinicians need to know about the possibilities of developing the skin lesion along with other early side effects before administering iodine-131 therapy.
Administration, Topical ; Female ; Humans ; Hypersensitivity ; Iodides ; Iodine ; Leg ; Skin ; Sodium Iodide ; Thyroid Gland ; Thyroid Neoplasms

Failure of a glaucoma filtering surgery mainly results from scarring at thefiltering wound. Postoperative proliferation of fibroblasts plays an imrortant role in scar tissue formation. Colchicine is a cytoplasmic microtubule inhibitor capable of inhibiting fibroblast proliferation. The effect of colchicine on fibroblast proliferation at the filtering wound after filtering surgery was investigated. Posterior lip sclerectomies were performed in each eye of albino rabbits.Intraocular pressures, conjunctival fibrosis, histologic findings and drug tox-icities were examined postoperatively under the topical or oral administration of colchicine. Reductions of intraocular Pressure and conjunctival fibrosis in colchicinetreated groups after filtering surgory were statistically significant (p< 0.05), and changes in the topical administration group were more significant than in the oral administration group (pl 0.05). Histologicallyr reductions of active fibroblasts and collagen fibers at the filtering wound and the subconjunctival area were seen in colchicine treated eyes.Histologic changes were more prominent in the topical administration group. Signs of orular and systemic toxicity were absent. The above results suggest that administration of colchicine, especially topicaladministration, can increase the success rate of filtering surgery.
Administration, Topical ; Animals ; Colchicine/*pharmacology ; Fibroblasts/*drug effects ; Glaucoma/*surgery ; Rabbits

Subcutaneous and topical epinephrine are widely used for hemostasis during dermatologic procedure. There was substantial variation in the amount of systemic absorption on the basis of patient's general condition, blood supply of wounds. Increased or unpredictable absorption after topical administration may increase anesthetic and cardiovascular risks. There have been no reports about cardiovascular complications developed during laser resurfacing. We experienced a case of transient hypertension, cardiac arrhythmia and ST-depression during whole face resurfacing by Erbium-Yag laser due to application of high concentration epinephrine gauze on the face. The hypertension and arrhythmia were normalized in 2 minutes, and ST-depression was sustained for about 4 hours.
Absorption ; Acne Vulgaris* ; Administration, Topical ; Arrhythmias, Cardiac* ; Cicatrix* ; Epinephrine ; Hemostasis ; Hypertension* ; Wounds and Injuries