[Objective]To determine the efficacy of early versus late reconstruction for anterior cruciate ligament rupture.[Method]The author searched MEDLINE(1950-2007.4),OVID(1950-2007.6),PUBMED(1950-2007.7),the CBM(1978-2007.6),WanFang(1981-2007.6),and hand-searched several related journals for randomized controlled trials(RCTs)and quasi-randomized controlled trials(quasi-RCTs)involving the efficacy of early versus late reconstruction for anterior cruciate ligament rupture,the quality of the included trials was assessed.RevMan 4.2.8 software was used for statistical analysis.[Result]Ten studies were included(1RCT,9 CCT).The results of meta-analysis indicated that the huge heterogeneity consist in as follows:intraarticular meniscus tears of the knee,extension deficit of the knee,comparison of lysholm of the knee after the operation.No statistically significant differences between the two operative procedures were observed as follows:including the result of incidence of intraarticular chondral damage of the knee,comparison of Lachman test of the knee found after the operation as well as the result of incidence of comparison of Pivot test of the knee found after the operation.Statistically significant differences were more observed in the late reconstruction in the clinical outcome of both intraarticular arthofibrosis and flexion deficit of the knee found after the operation than that of early reconstruction.[Conclusion]Although result obtained on the basis of CCT with a lager bias and one RCT,the author still conclude that statistically significant differences are more observed in the late reconstruction in the clinical outcome of both intraarticular arthofibrosis and flexion deficit of the knee found after the operation than that of early reconstruction.More high quality,large-scale randomized controlled trials are required for the accurate conclusion in treating it.