No abstract available.
Abdomen, Acute*

Introduction: Different solvents extraction was used to extract the good fatty acid composition of Dabai fruits. Nevertheless, solvents extraction may exhibit harmful effects. The present study was aimed to evaluate the safety of using supercritical carbon dioxide extraction (SCO2) of dabai pulp oil by acute toxicity study in Specific Pathogen Free (SPF) Sprague-Dawley (SD) rats. Methods: The CO pulp oil extract was prepared by SCO2 extraction of the freezedried pulp and was administered orally to SPF SD rats (consisted of 5 rats/sex/group) at upper limit dose 5000 mg/kg body weight (BW) for 14 days. The study includes the control and treatment groups, each consisting of 5 male and female rats. The rats were fed and allowed to drink sterilized water ad libitum. Fatty acid composition (FAC) of the extract was determined using GC-FID. Electrolytes and biochemical parameters in blood, as well as relative organs weight were measured. Results: The extract at a single dose of 5000 mg/kg did not cause any acute toxicity effects or mortality to the treatment of rats during observation periods in 14 days. FAC of the SCO2 extracted oil exhibited high content of palmitic and linoleic acids. The relative organs weights (ROW) and histopathology of rats were within normal range. Conclusion: Thus, the LD50 was estimated to be more than 5000 mg/kg of CO pulp oil extract and can be considered for further investigation for its therapeutic efficacy in a larger animal model
Acute toxicity

Introduction: Thymoquinone (TQ), a bioactive compound from Nigella sativa is known for its various medicinal properties. Due to the low solubility of TQ, nanostructured lipid carrier (NLC) has been used as a delivery system to improve its efficacy. Nevertheless, the effect of TQ-NLC when administered intravenously is unclear. This study investigated the acute toxicity profile of intravenous administration of TQ-NLC in an in vivo model. Methods: Twelve female Sprague dawley rats were assigned randomly into two groups (n=6); a control and a treatment group that received normal saline and 25 mg/kg TQ-NLC, respectively, via intravenous injection. The rats were observed for 14 days for any alterations to their usual physical conditions such as behaviour and mortality, body weight, food intake, organ-to-body weight ratio, and haematological, biochemical and histopathological profile. Results: There were no significant changes (p>0.05) in the body weight, food intake, organ-to-body weight ratio, and haematological, biochemical and histopathological profile between TQ-NLC treatment and the control group. However, inflammation was observed at the site of injection on the rat’s tail. Conclusion: Intravenous administration of TQ-NLC (25 mg/kg) did not exert acute toxic effect in female Sprague dawley rats. The data can be used as a basis to further develop TQNLC as a potential therapeutic drug.
Acute toxicity

No abstract available.
Leukemia, Megakaryoblastic, Acute*

No abstract available.
Porphyria, Acute Intermittent* ; Pregnancy*

No abstract available.
Acute Kidney Injury*

No abstract available.
Humans ; Leukemia, Myeloid, Acute*

No abstract available.
Acute Kidney Injury*

The maximal doses of Pancreatine, in concentrations of 1.5%o and 3%o that can be given in mice, equivalent 0.450g/1ml distilled water/mouse (preparation 1.5%o and 0.90g/1ml distilled water/mouse (preparation 3%o, ie 200 times the dose for pigs, were administered in mice orally. After the trial of acute toxicity, our finding are as follows: After 72 hours signs of poisoning or deaths were not observed. LD50 could not be determined because of the potential low toxicity of the product
Acute Toxicity Tests ; Poisoning

An interventive study on the 7th communes, Ho»ng Ho¸ district, Thanh Ho¸ province during4/1994 -12/1996 aimed to determine some factors that impacted on efficacy of the home treatment of acute diarrhea. The result showed that more than 50 health cadres did not instruct or incorrectly instructed the method of preparation as well as method of using some self- prepared solutions such as water of boiled rice, salt porridge and fried rice water..10% health cadres did not instruct about the use of traditional medicine or anti-diarrhea drugs. 37,5% health cadres did not instruct for mother about the more severve signs that need take children to health station leading to 8,33% patients with severe dehydration when coming to health station.
diarrhea ; Acute Disease