Background: Acute renal failure (ARF) is an uncommon but alarming complication of idiopathic nephrotic syndrome. The renal failure could be secondary to causes evident from the history and evaluation, such as severe intravascular volume depletion, acute tubular necrosis but there is no report on this population in Vietnamese adult patients. Objective: To investigate on acute renal failure complicating of nephrotic syndrome. Subjects and method: Patients with idiopathic nephrotic syndrome who were admitted with acute renal failure have been enrolled to investigate the clinical findings, laboratory check up and histology examination. Results:We present 33 patients with idiopathic nephrotic syndrome who were admitted with acute renal failure between June 1997 and June 1998. We describe the clinical and renal pathology features of these patients in whom reversible idiopathic acute renal failure developed during the course of primary nephrotic syndrome (PNS). Improvement in renal function occurred in 80% of patients over a variable period of 10 days to 14 days. The histology findings are interstitial edema, tubular obstruction. Conclusions: Acute renal failure complicating of nephritic syndrome is reversible, the exact pathophysiology of ARF is not understood. Possible causes include edema, tubular obstruction, altered glomerular permeability, and unrecognized hypovolemia.
Acute Kidney Injury/ pathology Nephrotic Syndrome ; Adult

Background: Acute renal failure is a common emergency and esspecial dangerous in the neonatal disease group, account for from 8% to 24% of among total patients to be treated at Intensive Care Unit with the high rate of mortality and complication. The mortality rate due to acute renal failure in neonatal group account for from 24.4% to 66,7%. Objectives: This study aims to learn about the clinical and laboratory characteristics as well as some risks factors of neonatal acute renal failure. Subjects and method:A descriptive, retrospective study was conduct on 64 patients without diagnosed of acute renal failure in control group and other 32 cases of acute renal failure whom treated at Neonatal Department of National Hospital for Pediatric from 1st January 2005 to 31st March 2006. Results:The diagnosis was often done in the 1st week of life and the incidence occurred in boy more than in girl.The average reatininernie\r\n', u'was 251.7\xb112.96 \xb5ol/l, the electrical disorder (in which hyperkaliernie: 78.1%, hyponatrernie: 46.9%), anernie was 18.7%, acidosis netabolique was 71.9%. Risk factors of neonatal acute renal failure: the pre-puerperal eclampsia (p = 0.023, OR=1.23), infection (p <0.001, OR = 9.53), suffocation (p <0.05, OR = 2.489), respiratory failure (p <0.001, OR = 2.489). Conclusion: The clinical signs were hyponurie and anuria, oederne and arterial hypertension.\r\n', u'\r\n', u'
Acute Kidney Injury/ diagnosis ; pathology ; Infant

Background: Acute myelogenous leukemia (AML) is the most common disease of malignant hemopathy in adult. Although induction therapy induced the long complete remissions, but complications of this intensive therapy is very serious. Objectives: to evaluate the complications of induction chemotherapy in adult patients with acute myelogenous leukemia at Hue central hospital". Subject and method: 30 AML patients aged from 10 to 30 were treated at clinical hematology service, Hue central hospital from Mars, 2005 to July, 2006. The diagnosis of AML based on FAB classification. Induction therapy consisted of a combination of cytarabin 100mglm2/day given by continuous IV over 7 days and daunorubicin 45mg/m2/day for 3 days. Complications were evaluated based on toxicity grade of WHO. \r\n', u'Results: Alopecia was the most common complications (100%) but good recovery. Gastrointestinal toxicity included: nausea and vomiting (6.6%), oral mucositis (40%) and diarrhea (30%) Cerebral hemorrhage due thrombocytopenia (6.66%) and neutropenic septicemia (20%) are the most severe complications. Acute complications on cardio - vascular system were rare and only mild degree. Conclusion: The complications of induction chemotherapy in adult patients with acute myelogenous leukemia occur at many organs with different degrees. Among of them, bone marrow suppression is the most severe complication with cerebral hemorrhage due thrombocytopenia and neutropenic septicemia which are fatal complications in theses patients. \r\n', u'\r\n', u'
Leukemia ; Myeloid ; Acute/ complications ; pathology ; drug therapy

Acute Disease ; Adult ; Cholecystitis, Acute ; diagnosis ; pathology ; Diagnostic Errors ; Female ; Humans ; Myocarditis ; diagnosis ; pathology

Acute pancreatitis (AP) is a common and potentially life-threatening pancreatic inflammatory disease. Although it is usually self-limiting, up to 20% of patients will develop into severe AP. It may lead to systemic inflammatory response syndrome and multiple organ dysfunction, affecting the lungs, kidneys, liver, heart, etc. Surviving patients usually have sequelae of varying degrees, such as chronic hyperglycemia after AP (CHAP), pancreatic exocrine insufficiency, and chronic pancreatitis. Lacking specific target treatments is the main reason for high mortality and morbidity, which means that more research on the pathogenesis of AP is needed. Ferroptosis is a newly discovered regulated cell death (RCD), originally described in cancer cells, involving the accumulation of iron and the depletion of plasma membrane polyunsaturated fatty acids, and a caspase-independent RCD. It is closely related to neurological diseases, myocardial infarction, ischemia/reperfusion injury, cancer, etc. Research in the past years has also found the effects of ferroptosis in AP, pancreatic cancer, and AP complications, such as acute lung injury and acute kidney injury. This article reviews the research progress of ferroptosis and its association with the pathophysiological mechanisms of AP, trying to provide new insight into the pathogenesis and treatment of AP, facilitating the development of better-targeted drugs.
Humans ; Pancreatitis/pathology* ; Acute Disease ; Ferroptosis ; Pancreas/pathology* ; Acute Lung Injury/metabolism*

OBJECTIVETo study the morphological features of the lungs obtained from autopsies of severe acute respiratory syndrome (SARS) patients.

METHODSBilateral lungs from 7 patients died from SARS were carefully studied grossly and microscopically. All tissues from these cases were routinely processed and carefully studied.

RESULTSAll lungs from these cases were extremely expanded and became solid. Microscopically, the edema and fibrin exudates in the alveoli was the most common findings, especially in the early phase of the disease. The hyaline membrane was almost always present in the lungs of these cases. The organization of intra-alveolar fibrin exudates along with the interstitial fibrosis led to obliteration of alveoli and consolidation of lungs. The desquamation and hyperplasia of alveolar lining cells was also apparent. Foci of haemorrhage and lobular pneumonia, even diffuse fungal infection were frequently seen in these specimens. Micro-thrombus were easily found in these lungs.

CONCLUSIONSThe lung of SARS from autopsy is characterized by edema, intra-alveolar fibrin exudates, hyaline membrane formation, organization of intra-alveolar exudates and fibrosis, which lead to the obliteration of alveoli and consolidation of lungs.

Adult ; Female ; Humans ; Lung ; pathology ; Male ; Middle Aged ; Pulmonary Fibrosis ; pathology ; Severe Acute Respiratory Syndrome ; pathology

Adult ; Aspergillosis ; pathology ; Humans ; Lung Diseases, Fungal ; pathology ; Male ; Severe Acute Respiratory Syndrome ; pathology

Acute pancreatitis is one of the common surgical acute abdominal diseases. Since people first recognized acute pancreatitis in the middle of the nineteenth century, a diversified minimally invasive treatment model with standardization has been formed today. According to the main line of surgical intervention of acute pancreatitis treatment,this period can be roughly divided into five stages:exploration stage, conservative treatment stage, pancreatectomy stage, debridement and drainage of the pancreatic necrotic tissue stage, and minimally invasive treatment as the first choice led by the multidisciplinary team mode stage. Throughout history, the evolution and progress of surgical intervention strategies for acute pancreatitis cannot be separated from the progress of science and technology, the update of treatment concepts and the further understanding of the pathogenesis. This article will summarize the surgical characteristics of acute pancreatitis treatment at each stage to explain the development of surgical treatment of acute pancreatitis,to help investigate the development of surgical treatment of acute pancreatitis in the future.
Humans ; Acute Disease ; Treatment Outcome ; Debridement ; Pancreatitis, Acute Necrotizing/pathology* ; Drainage

Acute Disease ; Adult ; Humans ; Hydrogen Sulfide ; poisoning ; Male ; Poisoning ; pathology

Humans ; Pancreatitis, Acute Necrotizing ; pathology ; therapy ; Time Factors