Study 3 representative districts of Ho Chi Minh city on number of people and the risk of acquiring HIV. The result shows some factors relating to high risk of acquiring HIV: 75,8% HIV found in drug addicted persons, especially the number of prostitute using drug tends to increase, and risker is easy and depraved life including using the same injection needle and do not use comdon when clients order. Besides, other factors include street children with the age of 10 to 19, construction workers. Therefore, there is a need to improve the awareness and practice skills to change behaviors leading to high level of acquiring HIV. And enhance the capacity of staff and their profession and skills in managing, caring, consulting and treating HIV-infected persons
HIV ; transmission ; Acquired Immunodeficiency Syndrome

From Jaruary 5 to 14/2003, in Lang Son, an interview was conducted involving 131 subjects discussing about the risk of transmission of HIV. They are: users of intravenous drug injection, prostitutes and their sex partners, stress children, HIV patients… There were 1393 intravenous drug users, this number was not reduced, even increased sex worker group includes 50 subjects with the trend of increase gradually. There are potential risk behaviours. Among about 150 street children, 20-30% had sex intercourse with prostitutes, 10-20% girls were forced in sex relation. The increasing groups of 600-800 of public motobikes drivers, who had risk sexual behaviours with prostitute, were an important cause of HIV transmission
HIV ; transmission ; Acquired Immunodeficiency Syndrome ; epidemiology ; risk factors

A 1997-2002 retrospective study of data related to AIDS control in Nge An province was conducted. The state, the tendency and transmission risks of HIV in subjects with high risk behaviours were uncontrolled. About 4313 subjects having high risk behaviours of transmission of the disease. Among about 257 sex workers, 30-50% injected intravenous drugs, 30-40% sharing injection needle with their partners, 2-10% did not use condom. About 450 street children, among them girls 1% beared sexual violation, 3-5% were intravenous drug users. Among about 500-1000 public motobike driver, 1-3% were intravenous drug user, 10-20% sharing needle
HIV ; Acquired Immunodeficiency Syndrome ; transmission ; epidemiology ; risk factors

Acquired Immune Deficiency Syndrome (AIDS) has been one of the main public heath problems that the Chinese public is facing. In order to estimate and predict the development of the epidemic situation, we studied on cellular automaton with the mechanism and characteristics of AIDS, and sets up an AIDS model on the base of the principle of cellular automaton. By studying the model, we analyzed the segregation power and AIDS-immune persons' influence on the transmission of the diseases. Some estimations and predictions can be drawn by studying model parameters. The structure of the model is flexible, and so it can change control tactics during evolution. Traditional differential equation cannot come up to it under the circumstances. It serves as tool with a great significance to the control as well as the prevention of AIDS.
Acquired Immunodeficiency Syndrome ; epidemiology ; transmission ; China ; epidemiology ; Humans ; Models, Theoretical

The virology of human immunodeficiency virus (HIV) infection is reviewed. The transmission of HIV is restricted to direct contact with the blood or other body fluids of infected human beings. Ordinary social contact with infected individuals holds no risk but in the health care setting all patients must be considered to be potentially infectious and universal precautions taken. The replication of HIV in cells of the immune system carrying the CD4 receptor creates a complex relationship between the virus infection and the host immune response. The pathogenesis and the principles of the laboratory diagnosis of HIV infection are reviewed. Since its discovery HIV has quickly become one of the most studied and best characterized of human pathogens. The diagnosis of HIV infection, because of its implications, has been made more accurate than for any other infection. This understanding has significantly improved treatment but has yet to provide curative therapy, and prevention of infection is still the basis of the fight against AIDS.
Acquired Immunodeficiency Syndrome - pathology ; Acquired Immunodeficiency Syndrome - transmission ; Animals ; HIV Antibodies - analysis ; HIV Infections - diagnosis ; Serologic Tests ; Virus Replication - physiology

Acquired Immunodeficiency Syndrome ; transmission ; China ; HIV Infections ; transmission ; Humans ; Models, Theoretical

Acquired Immunodeficiency Syndrome ; epidemiology ; transmission ; Female ; Homosexuality, Female ; Humans ; Risk-Taking

OBJECTIVETo uncover the transmission patterns of the HIV epidemic in Dehong prefecture.

METHODSThe reviewed case reports, data of sentinel surveillance, testing and special survey were analyzed by SAS 8.0 program. The transmission patterns were modeled by utilizing data including sizes of the whole population and the high risk groups, high risk behavior data from 1989 to 2007, and the population index such as sex ratio and fertility rate.

RESULTSIn 2005, case reports showed the proportion of people infected with HIV through sexual contact was 39.1%, and 46.9% in 2006. Among 1636 cases reported between January 1 to September 20, 2007, the proportion of people infected with HIV through sexual contact was 52%. From 1989 to 2007, the proportion of HIV infection among drug users was declining, while HIV infection through sexual contact was rising after standardizing the population tested/surveyed. The Asian Epidemic Model has shown that the proportions of incident HIV infections through sexual transmissions were 50.6%, 52.3% and 52.7% respectively from 2005 to 2007. Correspondingly, the proportions of incident cases by injecting drug user were 48.9%, 47.2% and 46.7% respectively during this period. Moreover, the Workbook method has shown that, among adults living with HIV in 2007, 50.3% were infected through injecting drugs and 48.4% through unsafe sexual activity.

CONCLUSIONThe rapid rise in HIV infections through injecting drug in Dehong prefecture has been initially curbed. HIV epidemic has already witnessed a change from predominantly through drug injecting-related activity to an almost equally fuelled epidemic by sexual and drug-related transmission.

Acquired Immunodeficiency Syndrome ; epidemiology ; transmission ; China ; epidemiology ; Humans ; Models, Statistical ; Risk Factors ; Social Problems

Objective To study the expression of selenoprotein genes in human immunodeficiency virus(HIV)infection and its mother-to-child transmission,so as to provide a theoretical basis for the prevention,diagnosis,and treatment of acquired immunodeficiency syndrome.Methods The dataset GSE4124 was downloaded from the Gene Expression Omnibus(GEO).Two groups of HIV-positive mothers(n=25)and HIV-negative mothers(n=20)were designed.HIV-positive mothers included a subset of transmitter(TR)mothers(n=11)and non-transmitter(NTR)mothers(n=14).Then,t-test was carried out to compare the expression levels of selenoprotein genes between the four groups(HIV-positive vs. HIV-negative,NTR vs. HIV-negative,TR vs. HIV-negative,TR vs. NTR).Univariate and multivariate Logistic regression were adopted to analyze the effects of differentially expressed genes on HIV infection and mother-to-child transmission.R software was used to establish a nomogram prediction model and evaluate the model performance.Results Compared with the HIV-negative group,HIV-positive,NTR,and TR groups had 8,5 and 8 down-regulated selenoprotein genes,respectively.Compared with the NTR group,the TR group had 4 down-regulated selenoprotein genes.Univariate Logistic regression analysis showed that abnormally high expression of GPX1,GPX3,GPX4,TXNRD1,TXNRD3,and SEPHS2 affected HIV infection and had no effect on mother-to-child transmission.The multivariate Logistic regression analysis showed that the abnormally high expression of TXNRD3(OR=0.032,95%CI=0.002-0.607,P=0.022)was positively correlated with HIV infection.As for the nomogram prediction model,the area under the receiver-operating characteristic curve for 1-year survival of HIV-infected patients was 0.840(95%CI=0.690-1.000),and that for 3-year survival of HIV-infected patients was 0.870(95%CI=0.730-1.000).Conclusions Multiple selenoprotein genes with down-regulated expression levels were involved in the regulation of HIV infection and mother-to-child transmission.The abnormal high expression of TXNRD3 was positively correlated with HIV infection.The findings provide new ideas for the prevention,diagnosis,and treatment of acquired immunodeficiency syndrome.
Humans ; Female ; HIV Infections ; Acquired Immunodeficiency Syndrome ; Infectious Disease Transmission, Vertical ; Nomograms ; Selenoproteins/genetics*

OBJECTIVETo analyze the current status of maternal HIV infection, mother to child transmission, and the work accomplishments in preventing mother-to-child transmission of HIV (PMTCT).

METHODSDuring October, 2001 to May, 2009, HIV voluntary consultation and examination were carried out in 339 866 pregnant women in the urban areas, while 594 pregnant women who tested positive were intervened, and interventions were also conducted among 326 babies who were born to HIV positive mothers, including HIV immune body examination on the babies when they were 12 months and 18 months old.

RESULTSA total of 594 pregnant women were found HIV positive, with the positive rate of 0.17% (594/339 866). And the rate was declining year by year. The highest rate was 0.47% (37/7837) in 2002, and the lowest rate was 0.12% (86/73 343) in 2008. Of the 594 positive pregnant women, 228 (38.38%) terminated pregnancy voluntarily, 43 (7.24%) kept on pregnancy and 317 (53.37%) parturients. Of 326 babies born by the 317 parturients, 317 survived.298 received curbing intervention for mother to child transmission (PMTCT), the ratio was 94.01% (298/317). Of 224 babies who were 18 months old, 221 accepted examination, and 7 HIV positive. The maternal infant transmission rate after intervention was 3.17% (7/221).

CONCLUSIONThrough the prevention of mother-to-child transmission of HIV, the HIV infection status in the pregnant women can be timely observed, which can effectively decrease the level of mother-to-child transmission of HIV.

Acquired Immunodeficiency Syndrome ; prevention & control ; transmission ; Adult ; China ; Female ; Humans ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; prevention & control ; Pregnancy