1.Clinical Correlates of Erectile Dysfunction among Male Patients on Methadone Maintenance Therapy (MMT) in Kuala Lumpur
NJ Nik Ruzyanei ; M Noormazita ; B Azlin ; I Normala ; Z Hazli ; S Abdul Aziz ; S Hatta
Malaysian Journal of Medicine and Health Sciences 2012;8(1):27-35
Introduction: Sexual dysfunction is common but not often assessed in the routine clinical care among
males on opiate substitute treatment. Objective: To determine the association between clinical variables
and erectile dysfunction (ED) among men on methadone maintenance therapy (MMT). Methods: A
cross-sectional study involving 108 participants who attended the Drug Clinic, Hospital Kuala Lumpur.
The instruments used include the Structured Clinical Interview for DSM-IV Axis-I Disorder (SCID-I),
Beck Depression Inventory (BDI) and International Index of Erectile Function-15 (IIEF-15). Results:
Concurrent heroin abuse was significantly associated with presence of ED (p=0.024). Treatment factors
including methadone dose and duration of methadone treatment were not significantly associated with
ED. Conclusion: Education on sexual dysfunction as a potential adverse effect and its association
with illicit heroin use should be considered in the doctor-patient consultation to encourage treatment
adherence and abstinence from heroin.
2.Combination Effect Of Argan Oil And Low Frequency Electromagnetic Field On Open Wound In Mice
Siti F. MASRE ; Muzamir M.K. ; Sabarina I. ; Jehan N. ; Yanti ROSLI
Malaysian Journal of Health Sciences 2018;16(Special Issue (Article)):41-45
This study was conducted to evaluate the effect of argan oil with the exposure of low frequency electromagnetic field (EMF)on open wound healing in mice. Eighteen male mice (20-40 g) were divided into three groups: phosphate buffer saline(PBS) as negative control, solcoseryl gel as positive control, and argan oil with the exposure of low frequency EMF, 1.2mT (treatment group). Full thickness wounds (4 mm diameter) were induced on the shaved dorsal of the mouse. All micewere sacrificed on day 12 after the final treatment. Macroscopic observation, wound contraction rate, histopathologyanalysis and total protein content were examined in this study. Results showed that wounds treated with argan oil andexposed to low frequency EMF has a significant increase in wound contraction rate (p < 0.05) and total protein content(p < 0.05). Moreover, histopathological analysis on the wound tissues displayed complete re-epithelization with thick anddense collagen fibers in the argan oil with low frequency EMF exposure treated group. In conclusion, topical treatment ofargan oil with low frequency EMF exposure yield a better healing progress and showed the ability to accelerate woundhealing.
3.Pharmacological and Safety Profile of Dexlansoprazole: A New Proton Pump Inhibitor - Implications for Treatment of Gastroesophageal Reflux Disease in the Asia Pacific Region.
Khean Lee GOH ; Myung Gyu CHOI ; Ping I HSU ; Hoon Jai CHUN ; Varocha MAHACHAI ; Udom KACHINTORN ; Somchai LEELAKUSOLVONG ; Nayoung KIM ; Abdul Aziz RANI ; Benjamin C Y WONG ; Justin WU ; Cheng Tang CHIU ; Vikram SHETTY ; Joseph C BOCOBO ; Melchor M CHAN ; Jaw Town LIN
Journal of Neurogastroenterology and Motility 2016;22(3):355-366
Although gastroesophageal reflux disease is not as common in Asia as in western countries, the prevalence has increased substantially during the past decade. Gastroesophageal reflux disease is associated with considerable reductions in subjective well-being and work productivity, as well as increased healthcare use. Proton pump inhibitors (PPIs) are currently the most effective treatment for gastroesophageal reflux disease. However, there are limitations associated with these drugs in terms of partial and non-response. Dexlansoprazole is the first PPI with a dual delayed release formulation designed to provide 2 separate releases of medication to extend the duration of effective plasma drug concentration. Dexlansoprazole has been shown to be effective for healing of erosive esophagitis, and to improve subjective well-being by controlling 24-hour symptoms. Dexlansoprazole has also been shown to achieve good plasma concentration regardless of administration with food, providing flexible dosing. Studies in healthy volunteers showed no clinically important effects on exposure to the active metabolite of clopidogrel or clopidogrel-induced platelet inhibition, with no dose adjustment of clopidogrel necessary when coprescribed. This review discusses the role of the new generation PPI, dexlansoprazole, in the treatment of gastroesophageal reflux disease in Asia.
Asia*
;
Blood Platelets
;
Delayed-Action Preparations
;
Delivery of Health Care
;
Dexlansoprazole*
;
Efficiency
;
Esophagitis
;
Gastroesophageal Reflux*
;
Healthy Volunteers
;
Plasma
;
Prevalence
;
Proton Pump Inhibitors
;
Proton Pumps*
;
Protons*
4.Could antiseptic gargling prevent COVID-19?
Mohamed, N.A. ; Ahmad Zainol Hady, A. ; Abdul Aziz, A.H. ; Isahak, I.
Tropical Biomedicine 2020;37(No.4):1141-1145
Coronavirus Disease 2019 (COVID-19) has infected more than 8 million people
globally since its discovery in December 2019. For COVID-19 prevention, the World Health
Organization recommended regular handwashing with soap, cough etiquette, mask wearing
and social distancing. However, COVID-19 is rather difficult to contain because of its high
transmissibility property. Gargling is effective for reducing infection in the respiratory tract.
Most antiseptic gargles have antimicrobial properties against common respiratory pathogens.
No published study on the effectiveness of antiseptic gargling among COVID-19 patients has
been available to date. This article reviewed available literature on methods and solutions
available for gargling and their effect on respiratory tract infections.
5.Are Dropped Bone Grafts Safe to be Re-used? - An Experimental Study Comparing Efficacy of Chlorhexidine, Povidone-Iodine and Alcohol
Mat-Salleh MF ; Sadagatullah AN ; Ibrahim MY ; Abdul-Aziz I ; Wan-Abdullah WA ; Maning N ; Md-Hassan MN ; Ab-Rashid MR
Malaysian Orthopaedic Journal 2021;15(No.2):70-76
Introduction: A dilemma arises when a bone graft or
fracture fragment is accidentally dropped on the operation
theatre floor and becomes contaminated. This study aimed to
determine the efficacy of simple and readily available
antiseptic solutions in disinfecting contaminated bones.
Materials and methods: This experimental study involved
225 bone specimens prepared from discarded bone
fragments during a series of 45 knee and hip arthroplasty
surgeries. The bone fragments were cut into five identical
cubes and were randomly assigned to either control (positive
or negative), or experimental groups (0.5% chlorhexidine,
10% povidone-iodine or 70% alcohol). The control negative
was to determine pre-contamination culture. All bone
specimens, except the control negative group were uniformly
contaminated by dropping on the operation theatre floor.
Subsequently, the dropped bone specimens except for the
control positive group, were disinfected by immersing in a
respective antiseptic solution for 10 minutes, before
transported to the microbiology laboratory for incubation.
Results: The incidence of a positive culture from a dropped
bone fragment was 86.5%. From the 37 specimens sent for
each group, the incidence of positive culture was 5.4% (2
specimens) after being disinfected using chlorhexidine,
67.6% (25 specimens) using povidone-iodine and 81.1% (30
specimens) using alcohol. Simple logistic regression analysis
demonstrated that chlorhexidine was significantly effective
in disinfecting contaminated bones (p-value <0.001, odd
ratio 0.009). Povidone-iodine and alcohol were not
statistically significant (p-value 0.059 and 0.53,
respectively). Organisms identified were Bacillus species
and coagulase negative Staphylococcus. No gram-negative
bacteria were isolated.
Conclusion: A total of 0.5% chlorhexidine is effective and
superior in disinfecting contaminated bones.