1.Villoglandular adenocarcinoma of cervix--a tumour with bland cytological features: report of a case missed on cytology.
The Malaysian journal of pathology 2003;25(2):139-43
The diagnosis of villoglandular adenocarcinoma of cervix on cytological smears is often missed due to the relatively bland cytological features of this tumour. A 45-year-old female with an exophytic cervical growth had three cervical smears reported as unsatisfactory. A cervical biopsy followed by Wertheim's hysterectomy showed a villoglandular adenocarcinoma (VGA) of cervix. Vaginal recurrence of VGA was again missed on the first post-operative vault smear. The second and third vault smears showed characteristic features of VGA that enabled correct identification. Review of some of the smears previously reported as unsatisfactory showed architectural features of VGA in the three dimensional (3-D) fragments that were previously considered to be benign.
Uterine cervix-Anatomy
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Adenocarcinoma
;
Cellular aspects of
;
Review of
;
seconds
2.Neonatal Clavicle Fracture: A Review of Fourteen Cases in East Coast Peninsular Malaysia
Awang MS ; Abdul Razak AH ; Che Ahmad A
The International Medical Journal Malaysia 2017;16(2):79-83
Introduction: The purpose of this study is to identify the incidence of clavicle fractures in newborn
associated with fetal, maternal and process of deliveries in Kuantan General Hospital from June 2012 until
January 2014. This study is to determine epidemiological data of clavicle fractures, maternal and baby risk
factors associated with clavicle fractures of newborn and its’ outcome. Methods: This is a prospective
study. 13 patients were identified to fulfill the inclusion criteria of the study. The data of
sociodemographic, associated fetal and maternal risk factors and the outcomes were recorded using
proforma. The statistical data analysis was done using SPSS 12.0. Results: Out of 20,257 live births at our
centre during the study period, 13 infants were diagnosed to have clavicle fractures, giving an incidence of
0.64 per 1000 live births. There were 5 (38.5%) left, 7 (53.8%) right and one (7.7%) bilateral fracture. All
fractures located at the mid shaft of the clavicle and none have associated brachial plexus injuries. All
infants were delivered through vaginal delivery (61.5%); five through assisted delivery (instrumental); 2
(15.4%) forcep and 3 (23.1%) vacuum. Two of the babies developed shoulder dystocia. The average birth
weight was 3371 grams (SD 0.269) and mean gestational age was 38.7 weeks (SD 1.16). Five of the mothers
(38.5%) were primigravida and eight (61.5%) were multigravida in which,7 (53.8%)were healthy without
other co-morbidty, 5 (38.5%) having gestational diabetis and one (7.7%) hypertension. The average maternal
weight was 62.0 kg and height 1.58 metres with average BMI of 24.16 (3.29SD). All eventually had a
complete recovery at 6 weeks with clinical and radiological evident of fracture union. Conclusions: In
conclusion, all patients with clavicle fractures were found following vaginal delivery. There were no
associations between neonatal clavicle fractures with maternal or baby risk factors. All fractures healed
without any complications.
3.Dual time point imaging of FDG PET/CT in a tuberculous spondylodiscitis
HR Abdul Razak ; N Abdul Rahim ; AJ Nordin
Biomedical Imaging and Intervention Journal 2010;6(2):1-3
Dual Time Point Imaging (DTPI) technique is a specialised protocol adopted in 18F-Fluorodeoxyglucose (FDG)
Positron Emission Tomography (PET) imaging. This technique is claimed to be useful in differentiating malignant and
infective lesions. The authors adopted this technique in a patient diagnosed with tuberculous spondylodiscitis and psoas abscess which demonstrated higher Maximum Standardized Uptake Value (SUVmax) during initial scans as compared with those obtained on delayed scans. The SUVmax changes between the two time points are believed to be a valuable finding for chronic granulomatous infective lesions such as tuberculosis.
4.Influence of Age, Weight, and Pirani Score on the Number of Castings in the Early Phase of Clubfoot Treatment using Ponseti Method
Mazlina Awang ; Abdul Razak Sulaiman ; Ismail Munajat ; Mohd Emil Fazliq
Malaysian Journal of Medical Sciences 2014;21(2):40-43
Background: The objectives of this study were to investigate whether severity of clubfoot, age, and weight of the patients at initial manipulation and casting influence the total number of castings required.
Methods: This prospective study was conducted on 38 idiopathic clubfoot patients undergoing weekly manipulation and casting using the method recommended by Ponseti. The patients’ age, weight, and foot Pirani score at the start of manipulation and casting were analysed against the total number of castings required to achieve correction to 60° abduction.
Results: Simple linear regression analysis on the influence of weight, age, and Pirani score at the time of cast initiation showed that the Pirani score was the only significant predictor for the total number of castings required.
Conclusion: The total number of castings required to treat clubfoot was determined by the severity of clubfoot but not by the weight and age of patients.
5.Cutaneous tuberculosis in Penang: A 12-year retrospective study
Tan WC ; Ong CK ; Lo Kang SC ; Abdul Razak M
Malaysian Journal of Dermatology 2008;21(-):75-80
Background Cutaneous tuberculosis (TB) is a form of extrapulmonary tuberculosis. Diagnosis of cutaneous TB is often difficult because of the diverse clinical presentations. The positive yields from
cultures are often low. To describe the demographic, clinical, histopathological and bacteriological aspects of cutaneous TB.
Materials and Methods This retrospective review looked at cases of cutaneous tuberculosis treated at the Respiratory and Dermatology unit, Penang Hospital from 1996 to 2007. Data were analysed with SPSS 13.0 version.
Results A total of 23 cases of cutaneous tuberculosis were reviewed. The male to female ratio was 2.3 to 1. The mean age was 37.7 ± 20.7 years. There were 10 Malays, 9 Chinese, 2 Indians and 2 Indonesian.
The types of cutaneous tuberculosis observed were lupus vulgaris (47.8%), tuberculides (17.5%), tuberculosis verrucosa cutis (13.0%), scrofuloderma (13.0%) and primary inoculation TB (8.7%). 43.5% of
patients had systemic involvement. Mantoux tests were positive in 85.0% of cases. Skin biopsies were performed in 91.3% of patients and 71.4% of them showed classical histopathologic findings suggestive of
tuberculosis. Mycobacterium tuberculosis was isolated in the culture from 28.6% of patients. Localized diseases were found more often in BCG-vaccinated individuals. Regional lymphadenopathy was noted
more often in patients with disseminated disease. No correlation was found between Mantoux reactivity and the extent of disease.
Conclusion Lupus vulgaris was the commonest form of cutaneous tuberculosis. Cultures were positive in only a small proportion of patients. Almost half of our patients had systemic involvement. The presence of regional lymphadenopathy often indicates disseminated
disease. Patients without BCG vaccination were at higher risk of disease dissemination.
6.An in vivo study of a locally-manufactured hydroxyapatite-based material as bone replacement material.
N H Abdul Razak ; K A Al-Salihi ; A R Samsudin
The Medical journal of Malaysia 2004;59 Suppl F():119-20
Defects were created in the mandible of a rabbit model whereby the right side was implanted with hydroxyapatite (HA) while the left side was left empty to act as control. Both the implant and control sites were evaluated clinically and histologically at 4,12,20,22 weeks. Decalcified sections were studied under confocal laser scanning microscope. No reactive cells were evident microscopically in all sections. There was bone ingrowth as early as 4 weeks when viewed by the topographic method. Enhancement of osteoconduction was evident by the presence of abundant capillaries, perivascular tissue and osteoprogenitor cells of the host. At 22 weeks, the implanted defect showed mature bone formation filling almost the whole field. This study demonstrated that the dense HA exhibits excellent biocompatibility as noted by the complete absence of reactive cells. It also promotes osteoconduction.
Materials
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Skeletal bone
;
week
;
Durapatite
;
in vivo study
7.An in vivo study of a locally-manufactured hydroxyapatite-based material as bone replacement material.
Abdul Razak NH ; Al-Salihi KA ; Samsudin AR
The Medical Journal of Malaysia 2004;59 Suppl B():119-120
Defects were created in the mandible of a rabbit model whereby the right side was implanted with hydroxyapatite (HA) while the left side was left empty to act as control. Both the implant and control sites were evaluated clinically and histologically at 4,12,20,22 weeks. Decalcified sections were studied under confocal laser scanning microscope. No reactive cells were evident microscopically in all sections. There was bone ingrowth as early as 4 weeks when viewed by the topographic method. Enhancement of osteoconduction was evident by the presence of abundant capillaries, perivascular tissue and osteoprogenitor cells of the host. At 22 weeks, the implanted defect showed mature bone formation filling almost the whole field. This study demonstrated that the dense HA exhibits excellent biocompatibility as noted by the complete absence of reactive cells. It also promotes osteoconduction.
*Bone Substitutes
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*Hydroxyapatites
;
Mandible/pathology
;
Mandible/*surgery
;
*Materials Testing
;
Osseointegration/physiology
8.Parental Issues Contributing To School Refusal: A Case Report
Siti Rohana Abdul Hadi ; Aida Harlina Abdul Razak ; Ek Zakuan Kalil ; Wan Salwina Wan Ismail
ASEAN Journal of Psychiatry 2014;15(1):83-85
Objective: This case report aims to highlight the importance of parental contribution to the school refusal problem. Methods: We report a case of a 9-year old boy who presented with school refusal behaviour. Results: There was no psychiatry diagnosis made in this patient. Parental issues such as ineffective and inconsistent parenting, and parental marital disharmony contribute significantly
to the school refusal behaviour. Conclusion: Parents in particular are important team players in the management of school refusal. Parental issues need to be
explored and managed accordingly to ensure good outcome.
Parents
;
Schools
;
Child
;
Behavior
9.Chronic Mania: Psychosocial Impact To The Family & Role Of Community Mental Health Team In Providing Care
Siti Rohana Abdul Hadi ; Suriati Mohamed Saini ; Aida Harlina Abdul Razak ; Marhani Midin
ASEAN Journal of Psychiatry 2014;15(2):217-219
Objective: This case report highlights the psychosocial complications of chronic
mania in a mother and the role of CMHT in improving the condition’s outcome.
Methods: We report a case of a Malay mother who had underlying chronic
mania for 20 years. Results: She was aggressive and abusive towards her
children causing tremendous trauma in them, had lost her child custody and
almost lost her husband to another woman. Lithium with multiple psychosocial
interventions delivered to the patient and her family had improved her mood
symptoms significantly and improved the family’s quality of life. Conclusion:
Chronic mania causes tremendously high illness burdens, and with extra care,
the outcome of the condition can be improved.
10.Memantine Augmentation In The Treatment Of Frontal Lobe Syndrome In Patients With End-Stage Renal Disease: A Case Report
Aida Abdul Razak ; T Maniam ; Hatta Sidi ; Shalisah Sharip ; Suriati Mohamed Saini
ASEAN Journal of Psychiatry 2014;15(1):93-96
This case report highlights the challenges in managing Frontal Lobe Syndrome (FLS) in a patient with end-stage renal disease. Methods: This is a case description of a 58 year-old gentleman who presented with behavioural changes: irritability, mood lability, aggression, psychosis, and overfamiliarity. His presenting symptoms were in keeping with (FLS) with positive findings on Computed Tomography (CT) scan of the brain and also neuropsychological
assessments. Difficulties arose in attempts to control his aggression without further compromising his renal function. Results: The usage of the commonly used antipsychotics in controlling aggression was restricted in view of the patient’s renal impairment. Augmentation with low dose memantine proved to be beneficial in this case, without causing further deterioration in renal function.
Conclusion: The use of memantine to augment the effect of risperidone was observed to be safe and successful in managing the behavioural changes associated with FLS in adults with end-stage renal disease.
Frontal Lobe
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Memantine
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Kidney Failure, Chronic