Background: Atrial Septal Defect (ASD) is a common congenital cardiac disease, accounting for 10% of congenital heart diseases and 1/3 congenital heart defect in adults. Closure of ASD is often used as a treatment method. However, there is controversial opinions about ASD closure in adult >=40. Objective: To study the outcomes of ASD closure of in adults >= 40 years. Subject and Method: 40 patients (27 female and 13 male) of ASD ostium secundum with an age average of 48.85 +/-5.91 (40 \u2013 62 years) and the mean ASD sizeof 27.53 +/-8.37 mm, mean Qp/Qs of 2.97 +/-1.59 had indications for ASD closure (clinically symptomatic and/or right ventricular [RV] enlargement by echocardiography). Follow-up at 1 week, 1 month, 3 months, 6 months after ASD closure. Results: Left ventricular systolic function was unaffected by ASD closure and the majority of the patients reported improvement in their symptoms. The right ventricle end-diastolic dimension and pulmonary artery diameter decreased significantly (p<0,0001). No trivial shunts. Conclusion: ASD closure is safe and effective in patient over 40 years of age with minimal complications. The procedure resulted in a decrease in the RV size that was accompanied by improvement in clinical symptoms.
Atrial septal defect ; Closure of ASD

Background: Atrial Septal Defect (ASD) is one of the most common congenital cardiac defects. Both surgical and catheter occlusion of the defect has been found effective and safe in eliminating interatrial shunting. However, knowledge of the response of the left side of the heart to ASD closure is incomplete. Objective: This study assessed the left side of the heart\u2019s response to ASD closure over a 6-month follow-up period. Subjects and method: 148 patients of ASD ostium secundum with an average age of 26.13 +/- 14.24 years (2-62 years) and the mean ASD size of 24.92 +/- 7.97 mm has been studied by echocardiography before and after atrial septal defect closure. Results: The right ventricular diameter and hemodynamics were improved after ASD closure (p<0.0001). The left ventricular end-diastolic diameter and volume increased significantly after ASD closure (p<0.0001). Conclusions: The left ventricular systolic function was unaffected by ASD closure. The right side of the heart\u2019s response to ASD closure over 6-month follow-up period decreased significantly (p<0.0001).
Atrial septal defect ; ASD ; left ventricular function