China ; Electrocardiography ; trends

Saireito, a 12-component Japanese herbal medicine, is used to treat immune-related diseases. We investigated the effects of oral administration of Saireito extract in a murine model of cardiac transplantation with fully mismatched allografts. Untreated recipients and those given water rejected their cardiac allografts acutely (median survival time [MST], 7 and 8 days, respectively), as did those treated with either 0.02 or 0.002 g/kg/day of Saireito extract (MST, 7 days in both groups). Recipients given 0.2 g/kg/day of Saireito extract had only moderate prolongation of allograft survival (MST, 41 days). However, all transplant recipients given 2 g/kg/day of Saireito extract had significant prolongation of allograft survival (MST>100 days). None of the single crude drug extracts of Saireito prolonged allograft survival, suggesting that its effects require administration of the combination agent. In mixed leukocyte cultures, proliferation of splenocytes from Saireito-treated CBA recipients was markedly suppressed compared with that of splenocytes from untreated mice, and interferon-γ production was significantly reduced. In flow cytometry experiment, the population of CD 4⁺CD 25⁺FOXP 3⁺cells was increased in the spleens of Saireito-treated CBA recipients compared with the spleens of naïve CBA mice or untreated CBA recipients. Thus, in our model, Saireito treatment induced hyporesponsiveness to cardiac allografts in a dose-dependent manner, and the combination of the components is essential for this effect.

Objective To evaluate the diagnostic value of color doppler imaging in lower limb deep vein thrombosis.Methods Application of color doppler ultrasonography,58 patients with clinically confirmed deep vein thrombosis were examined by the two-dimensional image,color characteristics and spectral characteristics of blood flow.Results The group of 58 cases had deep venous thrombosis,in which 37 cases were left leg,18 cases were right lower extremity,3 cases were lower limbs.By thrombosis of upper:iliofemoral type(central)in 35 cases,4 cases of pe-ripheral and mixed type in 19 cases.Conclusion Doppler ultrasound imaging to diagnose deep venous thrombosis was an effective method,and it had some guidance to select treatment methods.

Objective To study the effects of erythropoietin on expressions of myocardial cell Bcl-2 and Bax in rats with acute myocardial infarction(AMI).Methods Rats that survived after AMI were randomly divided into treatment group and control group. Treatment group were given EPO 3000 U/kg, A total of 3 d(preoperative 1 day, the same day, after 1 day),control group at the same point in time given the same amount of saline by the intraperitonealy injection. After 4 weeks, hemodynamics and left ventricular function were measured with catheterization,Bcl-2 and Bax were analyzed by immunohistochemical method. Results After 4 weeks, LVSP and +dp/dt_(max) in treatment group were significantly higher than those in control group(P＜0.05),LVEDP and-dp/dt_(max) were significantly lower than those in control group(P＜0.05);Change of heart rate in two groups were no difference(P＞0.05).The expression of myocardial cell Bcl-2 in treatment group were significantly higher than that in control group(P＜0.05);the expression of myocardial cell Bax and Bcl-2/Bax in treatment group were significantly lower than that in control group(P＜0.05).Conclusion The protective effect of EPO on ischemia and infarction of cardiac function may be related to the reduction of cardiomyocyte apoptosis.

Objiective To explore clinical pathologic characteristics, diagnosis and differential diagnosis of the cat-scratch diseases. Methods 2 patients with cat-scratch diseases were analyzed by histological observation and Warthin-Starry argentaffine fibers stain. Results One patient had a clearly medical history bitten finger by a roam a-bout cat. Histologically, the nodular was composed of epithelioid cells, multinuclear giant cells with a central necrot-ic. Conclusions The common etiology of the cat-scratch disease were Bartonella hensellae. These lesions greagly re-semble those of lymphogranuloma venereum and non-caseous tuberculosis. The diagnosis and differential diagnosis was based on the history, a specific cutaneous test and Warthin-Starry argentaffine fibers stain.

Execution is one of the key factors which influence the management level of hospital libraries. The paper introduces the concept, performance and synthesis patterns of execution, and points out that execution is the main means to enhance performance of li-brary, then puts forward concrete strategies to enhance execution of library from two levels: individuals and libraries.

Objective To study effects of high dosage of atorvastatin in acute coronary syndrome(ACS)patients on high sensitive creactive protein(hsCRP)and atherosclerosis.Methods 126 cases with ACS were divided into A,B and C group.30 patients in A group were given atorvastatin 20mg per night,41 cases in B group were given atorvastatin 40mg per night,while the other 55 patients in C group were taken atorvastatin 40mg per night and tirofiban in the first 24 to 48 hours.The patients were followed 6 months by evaluating serum hsCRP concentration,measuring the intimal thickness in the carotid artery with color Doppler.Results After treatment for 6 months,the patients in the three groups showed significant decrease in hsCRP,however,the therapeutic group showed significant difference amony the three groups.Additionally,the B and C groups further showed significant decrease in intimal thickness.Conclusion Using high-dose atorvastatin and tirofiban not only lowers hsCRP significantly,but also benefit stability of atherosclerotic plaque in carotid artery,and to reduce cardiovascular events.

Objective To explore the application of multislice computed tomographyic ( MSCT) perfusion imaging in the assessment of acute cerebral infarction. Methods 50 patients who initially diagnosed as acute cerebral infarction in 6 hours after their outbreak of infarction were selected. The Siemens semsation 4 MSCT was used to scan the patients and form time versus concentration curve analysis, including the comparision of region cerebral blood flow (CBF) between the necrosis region and the normal region, region cerebral blood volume (CBV), mean transit time ( MTT). Each case had to be examined by computed tomography at least once a week after infarction. Results 50 patients were found having a lower CBF and CBV in their necrosis region compared with the other side(P＜0.05) ,and had a longer MTT in their necrosis region compared with the other side( P ＜0.05) ,45 patients were observed a shrink of the size of the infarction region compared with the perfusion image in first 6 hours when they were reexamined by CT a week later(P ＜0.05) ,which proved the exist of ischemic penumbra area around the infarction center. Conclusion The multislice computed tomographyic perfusion imaging technology could define the infarction region and size at the early stage of acute cerebral infarction. It also provided clues to indicate the exist of a vascular area around the necrosis centre. It could diagnose acute cerebral infarction at hyperacute period and provide image proof for the thrombolysis in early period and treatment in individual manner.

The value and detection of right ventricular in circulation have been paid more attention,.Because of the defects in traditional method,Tei index is the method in right ventricular measurement.The Tei index is sensitive in assessing RV function of patients with congenital heart disease.It is not affected by valve regurgitation and RV geometry.The Tei index is accurate and simple in estimating right ventricular function in congenital heart disease and is valuable and invasive index in estimating right ventricular functions.

Objective To investigate the CR low dose radiography to COPD in patients with pseudo normal phenomenon.Methods 160 cases of COPD diagnosed,stratified random dividing method according to the pulmonary function test values were divided into A,B,C and D group.Each group had 32 cases,at the same time,the increase in lung function in patients with mild to moderate pulmonary emphysema in 32 cases was E group,wich was treated with normal dose as a control group,in the normal dose and low dose CR photography failed to clear the diagnosis of emphysema,causing false normalization,statistical the case number,and verify the pulmonary function classification criteria,identify false normalization of lesions in such a case,the general rule to judge the feasibility analysis and prevention.Results There was no significant chifference among 5 groups of pseudo normal comparison (x2 =4.56,P ＞0.05).Conclusion Chronic obstructive pulmonary disease with low dose CR photography on severe and extremely severe patients is deteded by emphysema detection with rate high.Moderate,mild COPD detection rate is extremely low.