Health Personnel ; psychology ; Humans ; Love ; Rare Diseases ; therapy

Recombinant human growth hormone (rhGH) has been widely used in clinical treatment of growth hormone deficiency(GHD),and has achieved satisfactory effect.Growth hormone (GH) can stimulate liver cells to produce insulin-like growth actor(IGF-1) which mediated GH growth promoting effect.The majority of IGF-1 combine with insulin like growth factor binding protein 3.IGF-I promotes cell mitotic and inhibit cell apoptosis,in recent years,some scholars have reported that there is a certain relationship between IGF-1 and tumor occurrence and development,and thus leading to the attention to the efficacy and safety of rhGH treatment.

Objective:To investigate the effect of vitamin E supplementation on oxidative stress in patients with MHD(maintenance hemodialysis).Methods:58 patients with MHD and 20 healthy volunteers were involved in this study.The patients were administered 400mg/d of vitamin E for 6 weeks.The plasma levels of oxidative parameters including vitamin E(VitE),malondialdehyde(MDA),advanced oxidation protein product(AOPP),superoxide dismutase(SOD),activity of glutathione peroxidase(GSH-PX) were measured at the initial and the end of VitE supplementation respectively.Results:Plasma levels of AOPP and MDA(187.27?54.9?mol/L vs99.05?26.2?mol/L,7.74?2.17nmol/ml vs3.06?1.70nmol/ml)were significantly higher in patients with MHD compared with healthy controls(P

OBJECTIVE:To study the determination method of the percutaneous rate of Kechuan xuewei patch and its in vitro drug release profile.METHODS:The content of ephedrine hydrochloride(an index composition)in percutaneous reception fluid and release fluid were determined by HPLC,and the percutaneous penetration rate and the in vitro drug release rate were computed.RESULT:Ephedrine permeated at a constant rate of 6.467 9 ?g?cm-2?h-1/2 and the in vitro drug release rate was 21.382 ?g?cm-2?h-1/2,fitting Higuchi equation.CONCLUSION:Kechuan xuewei patch can be prepared as controlled release matrix system of skin permeation rate-limited type.

OBJECTIVE:To evaluate the effectiveness and safety of an aerosol inhalation of Sodium Houttuyfonate injection in accessory treatment of pneumonia.METHODS:Biomedical databases,including Medline,EMbase,The Cochrane Central Register of Controlled Trials,CBM-disk and CNKI were searched.Randomized controlled trials(RCTs) and quasi-RCTs that compare aerosol inhalation of Sodium Houttuyfonate injection with placebo or other aerosol inhalation regimens were collected.A critical quality assessment and Meta-analysis were performed for included studies.RESULTS:Six RCTs were included and all of them were carried out in China.None of the trials described the method of randomization,allocation concealment,blind,and follow-up.With Junci scales,6 trials scored C degree.Compared with the control group,aerosol inhalation of Sodium Houttuyfonate injection showed significantly higher total improvement rate.We didn't find any RCTs describing the safety of Sodium Houttuyfonate injection aerosol inhalation.CONCLUSION:Because of the low quality of RCTs on Sodium Houttuyfonate injection aerosol inhalation for pneumonia and the lack of RCTs describing the safety of Sodium Houttuyfonate injection aerosol inhalation,no reliable conclusion can be drawn from our Meta-analysis about its efficacy and safety.Well-designed RCTs are urgently needed to evaluate the value and safety of aerosol inhalation of Sodium Houttuyfonate injection in treating pneumonia.

Objective To observe the effect of gastroscopy injection of norepinephrine combined with routine triple therapy on peptic ulcer with gastrointestinal bleeding. Methods 84 cases of gastroscopy upper gastrointestinal bleeding caused by peptic ulcer patients were randomly divided into two groups, the control group 42 cases;the observation group 42 cases, the observation group was guven endoscopic injection of norepinephrine combined conventional triple therapy,the control group was given conventional triple therapy with hemostatic therapy. Efficiency and adverse reactions were observed in patients. Results In the observation group,36 csses was significantly effective,5 cases was effective,1 case was not effective,the total effective rate was 97.6%. In the control group,21 cases was significantly effective, 16 cases was effective ,5 cases was not effective,the total effective rate was 88. 1% ,the difference of the total effective rate between the two groups was significant( x2 =5. 137, P ＜ 0. 05 ). There was no serious adverse reactions in the two groups. Conclusion Endoscopic injection of norepinephrine and routine triple therapy in treatment of gastrointestinal hemorrhage of peptic ulcer was significantly better than conventional medical treatment alone.

Evans syndrome is a rare autoimmune disease.Clinical presentation are the different degrees of bleeding and hemolysis,similar to immune thrombocytopenia and autoimmune hemolytic anemia.The treatments are divided into first-line therapy,second-line therapy and third-line therapy,including corticosteroids,intravenous immunoglobulin; immunosuppressive agents,splenectomy; haemopoietic stem cell transplantation,romiplostim and so on.The treatment of refractory Evans syndrome is difficult.Immunosuppressive agents and haemopoietic stem cell transplantation are effective.This review focuses on recent developments in the treatment of Evans syndrome.

Objective To investigate the correlation of fasting plasma glucose (FPG) in early period of pregnancy and abnormal glucose metabolism during gestation period.Methods Two hundred and seventy-seven women with single pregnancy and non-propregnant diabetes mellitus were selected.FPG,fasting insulin,insulin resistance index were detected in early period of pregnancy ( ＜19 weeks).One hundred g oral glucose tolerant test (OGTT) was taken during 24-36 weeks.According to OGTT,patients were divided into gestational impaired glucose tolerance (GIGT) group (24 cases),gestational diabetes mellitus(GDM) group(23 cases),OGTT 1 h higher blood glucose (HG-1) group (26 cases) and normal group (204 cases).Results FPG,fasting insulin and insulin resistance index of GDM group and HG-1 group were obviously higher than those of normal group [( 4.58 ± 0.36 ),( 4.58 ± 0.38) mmol/L vs.( 4.20 ±0.33) mmol/L,(9.4 ± 1.1),(9.3 ±2.1) U/L vs.(7.0 ± 2.1) U/L,2.0 ± 0.4,2.0 ± 0.3 vs.1.3 ± 0.4,P＜ 0.05].FPG of GIGT group [(4.45 ±0.36) mmol/L] was higher than that of normal group (P ＜0.05).After controlled age,body mass index,family history of type-2 diabetes mellitus and sport exercises,the relative risk degree of blood glucose metabolism had correlation with FPG,fasting insulin and insulin resistance index in early period of pregnancy (P ＜ 0.05).Conclusion FPG,fasting insulin and insulin resistance index in early period of pregnancy can predict abnormal glucose metabolism.

BACKGROUND:About 50% patients with coronary heart disease have no symptoms of cardiac disease before the first onset of myocardial infarction. Therefore, it is of great importance to make early and accurate detection of coronary heart disease and myocardial ischemia.OBJECTIVE: To measure the time of heart repolarization with magnetocardiography and probe into the role of non-invasive magnetocardiographic examination in evaluating cardiac function in patients with coronary heart disease.DESIGN: Case-control observation.SETTING: Department of Cardiology of Philippustift Hospital, Essen,GermanyPARTICIPANTS: Totally 52 patients hospitalized for suspected coronary heart disease in the Department of Cardiology of Philippustift Hospital(Essen, Germany) between March 1998 and December 2002 were recruited,and another 10 patients diagnosed as old myocardial infarction were set as myocardial infarction group. Informed consents were obtained from the patients. Totally 32 healthy volunteers aged above 40 years old were recruited as the control group.METHODS: All the patients received the following examinations: physical and laboratory examinations, rest and stress electrocardiography(ECG), echocardiography, coronary artery angiography and magnetocardiography(MCG) examination. The control group received only rest ECG and MCG examination. The values of QT dispersion with ECG and MCG were compared between the patients and healthy controls. The diagnostic criteria for coronary heart disease: stenosis of one coronary artery ≥ 75% according to coronary artery angiography; index of repolarization time of the heart was measured with MCG QT dispersion and MCG dispersion coincidence (the mean of probe signal and QT dispersion of peripheral probe in each MCG).MAIN OUTCOME MEASURES: ECG QT dispersion, MCG QT dispersion as well as coincidence index of QT dispersion of the observed subjects in each group.RESULTS: The 52 patients with suspected coronary heart disease,10 with myocardial infarction, and 32 healthy controls all entered the result analysis. The patients with suspected coronary disease were divided into 2 groups: group with coronary heart disease (n=27) and group without coronary heart disease (n=25). [1] Comparison of ECG QT dispersion: there was no significant difference among the groups(P ＞ 0.05). [2] Comparison of MCG QT dispersion: MCG QT dispersion in myocardial infarction group was significantly higher than that in control group [81.3±21.5, 52.4±13.6 (F=13.113, P ＜ 0.05)]. [3]Comparison of coincidence index of QT dispersion: Coincidence index of QT dispersion in myocardial infarction group and coronary heart disease group was both significantly higher than that in control group [15.6±4.2, 14.9±4.1, 10.2±2.7 (F=2.403, 3.332, P ＜ 0.01)].CONCLUSION: Compared with ECG, MCG can better reflect changes in the repolarization process of patients with coronary heart disease,and coincidence index of dispersion is superior to QT dispersion. This is because MCG is more sensitive to tangential currents presented at the precardial region when myocardial ischemia and infarction occur.

Renal interstitial fibrosis is basically the common terminal pathway of various progressive renal diseases. Decrease of interstitial capillary density plays an important role in renal interstitial fibrosis. Endothelial progenitor cells can be induced to differentiate into mature vascular endothelial cells. They contribute to angiogenesis and angiopoiesis, and therefore may be a potential therapeutic approach for chronic kidney disease..