Objective To reveal the trend of change incidence of hepatitis A(HAV)in Shandong province and explore dynamic analysis methods.Method Dynamic analysis was made on data of hepatitis A in Shandong province from 1990 to 2006.Results The reported incidence of hepatitis A patients dropped from 53.97/100,000 to 1.14/100,000 in Shandong province from 1990 to 2006,which showed a marked downward trend;the groups under the age of 10 dropped from 55.60% to 5.12%,the average age of incidence moved from 14.40 years old to 40.19 years old.Conclusion The incidence of hepatitis A has been changed from prevalent to sporadic in Shandong province,and there was a further downward trend;the age of the high-risk population has been shifted to older age group;the sex ratio of incidence between males and females in the population above 10 years of age had an expansion trend,the age distribution curve differences between males and females was also expanded.

Adolescent ; Humans ; Lung ; diagnostic imaging ; pathology ; Lung Neoplasms ; diagnostic imaging ; pathology ; surgery ; Male ; Papilloma ; diagnostic imaging ; pathology ; surgery ; Pneumonectomy ; methods ; Tomography, X-Ray Computed

Objective To observe the consistency of MRI imaging and pathological examination.To discuss the value of MRI imaging in assessing the curative effect of neoadjuvant chemotherapy in breast cancer.Methods 98 patients with breast cancer were selected as research subjects.All patients received six cycles of neoadjuvant chemotherapy,and underwent surgical treatment after the end of chemotherapy.All of them were performed with MRI examination before and after 6 cycles of chemotherapy.The evaluation of MRI in assessing the neoadjuvant chemotherapy and postoperative efficacy of breast cancer were compared for the consistency.Results The total effective rate by pathological examination of 98 cases of breast cancer after 6 cycles of neoadjuvant chemotherapy was 71 .4%,and the effective rate by MRI examination was 74.5%,and two evaluation results were basically consistent.The sensitivity, specificity and accuracy of MRI to assess the complete response (CR)patients after chemotherapy were 87.3%, 67.1 % and 78.2%,respectively,which of the partial response(PR)patients were 92.5%,59.7% and 85.9%, respectively.The tumor shrinkage of 22 patients was reduced towards the heart,with 23 branches reduced according to the MRI image.The average gap between MRI measured maximum tumor diameter and pathological examination results was (0.42 ±0.27)cm.Conclusion The evaluation of MRI in assessing the neoadjuvant chemotherapy was consistent with the pathology results,which could be used for clinical treatment and surgery program,worthy of clinical application.

Objective To establish and evaluate blood smear review criteria for hematology analyzer,use hematology analyzer accurately,rationally and efficiently,so as to establish the review criteria suitable for our hospital.Methods The blood smear review criteria was established according to characteristics of hospitals and XE-2100 type hematology analyzer,and microscopic examination was performed on 1368 cases of blood smears.Then the concordance of test results of the hematology analyzer and manual method was analyzed,and the feasibility of the criteria was evaluated.Results The comparative results of analyzer method and blood smear method were as follows:platelet reduction (Kappa=0.95,U=35.19,P<0.0 1;with good concordance);immature granulocyte (Kappa=0.64,U:24.9,P<0.01;with acceptable concordance);atypitical lymphocyte (Kappa=0.60,U:22.2,P<0.01;with acceptable concordance);shift to the left (Kappa=0.52,U=21.98,P<0.01,with acceptable concordance);platelet aggregation (Kappa=0.60,U=17.56,P<0.01;with acceptable concordance):myeloblast (Kappa=0.39,U=13.54,P<0.01;with poor concordance): erythroblast (Kappa=0.36,U=8.24,P<0.01;with poor concordance).According to the review standard,the sensitivety.specificity and accuracy were all higher(81.9%,99.0%A and 95.5%respectively).Conclusion The review standard has high sensitivity and specificity,which indicates the specimens in accordance with the review standard should be performed microscopic examination according to the operating instruction so as to reduce missed diagnosis and misdiagnosis,improve the quality of hematological analysis.

Objective:To introduce an economical and pragmatic method of establishing oxygen-glucose deprivation model for hippocampal slice of neonatal rats in vitro. Methods: Hippocampal slices(400?m) from 8~10-day-old rats were transferred into an incubator with insert of Millicell membrance and incubated for 7d,14d,20d and 30d respectively.Then they were observed under convened microscope to evaluate their growing state,and detected their ability to absorb propidiumiodide(PI) under fluorescent microscope after they had been stained by PI , The state of the hippocampal slices was observed at different time after aerating Nitrogen gas. Results:(1)No PI labelled cells were found after 7d and 14d.However,15% PI positive cells were found after 30d.(2)The longer in Nitrogen gas ,the more apoptosis cells.(3)Intensive fluorescence was observed in the CA1, CA3 and DG areas of the hippocampal slice after aerating Nitrogen gas for 1.5h.Conclusion:The hippocampal slice can be alive for about 30 days.Stable oxygen-glucose deprivation model of the hippocampal slice in vitro was successfully established after aerating Nitrogen gas for 1.5h.

Objective To compare the content of saponin in Bark of Silktree Albizziae and Bark of Silktree Albizziae kaldora derived from different collection periods.Method Spectrophotometry was used to determine the contents of saponin.Result The contents of saponin in one-year Bark of Silktree Albizziae is different from two-year Bark of Silktree Albizziae(P0.05).The contents of saponin in multi-year Bark of Silktree Albizziae is different from multi-year Bark of Silktree Albizziae kaldora(P

0.05).But only 23 lesions(38.3%)showed high signal on T1WI.Conclusion:This research confirmed the MRI-guided HIFU equipment is useful to monitor the HIFU treatment and evaluate the curative effect accurately,which provids a basis for the latter treatment of liver tumors.

0.05). Conclusion:The treatment system of MR Imaging guided HIFU is feasible and effective.

Objective To investigate the application of Prolene Hernia System (PHS) in day case tension-free inguinal hernia repair under local anaesthesia. Methods One hundred and seventy patients with inguinal hernia underwent day tension-free repair under local anaesthesia by using PHS (manufactured by Johnson Co., Ltd.) from February 1998 to February 2003. Results The operation time was (15～68) min, with a mean of 35 min. The patients remained in the hospital for (3～20) hours (mean, 8 hours), with slight wound pain and tugging after operation but no need for analgesics. No wound infection or urinary retention occurred. Scrotal hydrocele was found in 4 cases. There were no recurrence or sensation of foreign body in a follow-up period for (2～14) months (mean, 8 months). Conclusions PHS in day case tension-free inguinal hernia repair under local anaesthesia is safe and reliable.

Intertrochanteric fractures occur mostly in the elderly population. Direction of fracture line, lesser trochanteric fracture, comminution and displacement are the chief concerns in radiological diagnosis of intertrochanteric fractures. Interchanteric fractures can be classified by Evansgrading, Jensens modification of Evansgrading, AO classification, and so on, which are to judge the stability of the fracture. Currently, the basic priciple of management is operation and fixation. The common implants of internal fixation consist of two basic kinds: gliding compression screws with lateral plate, such as dynamic hip screws (DHS), and intramedullary nail fixation, such as Gamma nails and proximal femoral nails. Exteranl fixators are only applied in cases of severe multiple trauma and elderly patients, and artificial joint replacements in those of serere comminuted fractures combined with high osteoporosis.