OBJECTIVE:To prepare compound tretinoin cream No I,No II and observe their effects on chloasma.METHODS:The cream was prepared by taking tretinoin,kojoic acid and allantoin as main components and adding base material.The tretinoin was encapsulated with ?-cyclodextrin.RESULTS & CONCLUSION:The prescription of compound tretinoin cream is rational,preparation technic being stable and therapeutic effect on chloasma is satisfactory.
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