Background: Tuberculosis was a leading cause of mortality in the beginning of the twentieth century. However, it continues to be a major public health problem in developing countries. This study aimed to evaluate the clinical and radiological profi le of tuberculosis of the spine in northern Nigeria. Methods: Eighty seven patients with tuberculosis of the spine were studied for 4 years, the patients were recruited from in and outpatient Neurology Clinic of Aminu Kano Teaching Hospital, and Murtala Muhammed specialist Hospital (MMSH), Kano. Clinico-radiologic evaluation was carried out. Results: Eighty seven patients were recruited. There were 57 males and 30 females (M : F = 2 : 1), their age ranged between 15 – 70 years and the mean age was 41.3 + SD 15.2. Farmers were mostly affected (23%). Seventy fi ve percent of the patients presented more than 2 months after the onset of the illness. Paraplegia/paraparesis, sensory impairment over the lower limbs (100%) and back pain (90.8%) were the most common features. Nine (13.4%) patients had cauda equina syndrome and 3 (3.4%) had cold psoas abscess. Ten (11.5%) patients had been treated for pulmonary tuberculosis previously, 10 (11.5%) patients had concomitant pulmonary TB. Fifty eight (66.7%) patient had paraplegia. Twenty (23%) patients had normal fi nding on spinal X-ray. Conclusion: Tuberculosis of the spine is a common cause of morbidity in Northwestern Nigeria. Thus, there is increasing need to improve on the prevention of this disabling disorder.