1.Some opinions of tumors of sellar fossa and sellar region in Viet Duc Hospital during 01/1991 - 06/1996
Journal of Vietnamese Medicine 1999;233(2):97-104
87 patients had been operated on 5 years and six months in which there were: 47 pituitary adenomas, 23 craniopharyngiomas, 1 metastatic carcinoma and 4 undentified tumors. Masculine sex was 54/33 (60%) and a great number of patients was young. Almost patients came late with a voluminous size of tumor. The main signs were visual failure for every patients and endocrine disturbances especially in pituitary adenoma or craniopharyngioma. The outcome in general was favourable and acceptable: improvement of visual acuity, endocrine disturbances diminution and disapperance of headache. The mortatily was low. The recurrency rate was still low, but the followup in long term showed an increase of reoperated patients. Laboratory investigations (especially radioimmuno assay) and histopathological classification were our two limitations in this study.
Neoplasms
2.Differential Expression Patterns of Leukaemia Associated Genes in Leukaemia Cell Lines Compared to Healthy Controls
Ang Pei-Shen ; Rajesh Ramasamy ; Noor Hamidah Hussin ; Cheong Soon-Keng ; Seow Heng-Fong ; Maha Abdullah
Malaysian Journal of Medicine and Health Sciences 2016;12(1):32-45
Introduction: The phenotype and genotype of cancer cells portray hallmarks of cancer which may
have clinical value. Cancer cell lines are ideal models to study and confirm these characteristics. We
previously established two subtracted cDNA libraries with differentially expressed genes from an
acute myeloid leukaemia patient with poor prognosis (PP) and good prognosis (GP). Objective: To
compare gene expression of the leukaemia associated genes with selected biological characteristics
in leukaemia cell lines and normal controls. Methodology: Expression of 28 PP genes associated
with early fetal/embryonic development, HOX-related genes, hematopoiesis and aerobic glycolysis/
hypoxia genes and 36 GP genes involved in oxidative phosphorylation, protein synthesis, chromatin
remodelling and cell motility were examined in B-lymphoid (BV173, Reh and RS4;11) and myeloid
(HL-60, K562) leukaemia cell lines after 72h in culture as well as peripheral blood mononuclear cells
from healthy controls (N=5) using semi-quantitative polymerase chain reaction (PCR) method. Cell
cycle profiles were analysed on flow cytometry while MTT cytotoxicity assay was used to determine
drug resistance to epirubicin. Results: Genes expressed significantly higher in B-lymphoid leukaemia
cell lines compared to healthy controls were mostly of the GP library i.e. oxidative phosphorylation
(3/10), protein synthesis (4/11), chromatin remodelling (3/3) and actin cytoskeleton genes (1/5). Only
two genes with significant difference were from the PP library. Cancer associated genes, HSPA9 and
PSPH (GP library) and BCAP31 (PP library) were significantly higher in the B-lymphoid leukemia cell
lines. No significant difference was observed between myeloid cell lines and healthy controls. This
may also be due heterogeneity of cell lines studied. PBMC from healthy controls were not in cell cycle.
G2/M profiles and growth curves showed B-lymphoid cells just reaching plateau after 72 hour culture
while myeloid cells were declining. IC50 values from cytotoxicity assay revealed myeloid cell lines had
an average 13-fold higher drug resistance to epirubicin compared to B-lymphoid cell lines. Only CCL1,
was expressed at least two-fold higher in myeloid compared to B-lymphoid cell lines. In contrast,
MTRNR2, EEF1A1, PTMA, HLA-DR, C6orf115, PBX3, ENPP4, SELL, and IL3Ra were expressed
more than 2-fold higher in B-lymphoid compared to myeloid cell lines studied here. Conclusion: Thus,
B-lymphoid leukaemia cell lines here exhibited active, proliferating characteristics closer to GP genes.
Higher expression of several genes in B-lymphoid compared to myeloid leukaemia cell lines may be
useful markers to study biological differences including drug resistance between lineages.
Neoplasms
3.Management of malodour fungating wound with nanocrystalline silver coated dressing
Steffi Wong ; Zaliana Brahim ; Nur Amreen Aminuddin ; Norzatulsyima Nasirudin
The Medical Journal of Malaysia 2017;72(5):316-317
Chronic exudative malodorous fungating wound of four
years at the right arm due to diffuse large B cell lymphoma
managed with silver dressings. In two months of application
with nanocrystalline silver coated dressings, there was
significant improvement in wound.
Neoplasms
4.Psycholigical distress among cancer patients on chemotherapy
Journal of University of Malaya Medical Centre 2010;13(1):12-18
Distress has become a major issue in cancer population. Patients may suffer from either physical,
psychological distress or both. Cancer patients who are undergoing chemotherapy are more likely
to experience psychological distress. This could be due to the negative effects of chemotherapy
agents, the uncertainty of post-treatment, and the occurrence of psychosocial problems. As a
result, the patient may experience a normal reaction such as sadness or may develop common
psychiatric disorders such as depression and anxiety
Neoplasms
5.An Orbital Solitary Fibrous Tumor: Report of Two Cases with Different Presentation
Hanisah AH ; Othmaliza O ; Rona Asnida N ; Sunder R ; Hazlita MI
Journal of Surgical Academia 2016;6(2):18-21
Solitary fibrous tumour (SFT) is a rare spindle-cell neoplasm that can occur in the orbit. We report two cases of
orbital SFT in a 35-year-old female and a 28-year-old male with different presentations. First patient presented with
slowly progressive left lateral upper lid mass which is firm in consistency and non tender. Patient had non axial
proptosis as the mass compressed the globe inferonasally. There was also funduscopy evidence of choroidal folds
superotemporally. There is slight impairment of vision on the left eye comparing to right eye. Meanwhile, the second
patient presented with a painless diffuse swelling of left upper eyelid. It was soft in consistency, non fluctuate and no
opening or pus discharge noted. There is mild mechanical ptosis, however there was no proptosis and no evidence of
compression into the globe nor visual impairment.Computed tomography (CT) imaging revealed a well
circumscribed and contrast enhanced soft tissue mass intraorbital extraconal mass in both cases. However in the first
case, the tumour was at the level of lacrimal gland with compression of the globe, while in second case, it was
superior and posterior to the left lacrimal gland with no globe compression. Both patients underwent complete
resection of their tumors. The histological findings showed alternating hypercellular and hypocellular areas
composed of bland spindle cells with a fibrous stroma. The strong immunoreactivity for CD34 supported the
diagnosis of orbital SFT. There was no recurrence at the 2nd and 3rd year follow-up visits for both patients. SFT
should be considered as one of the differential diagnosis of an orbital tumor. The combination of CT scan, histologic
findings and immunohistochemical staining provide accurate diagnosis. En bloc excision of the tumour is the
mainstay of treatment.
Neoplasms
6.Desmoplastic Small Round Cell Tumour of the Uterus: A Case Report
Nur Zaiti MA ; Mohd Rushdan MN ; Lee SJ
Journal of Surgical Academia 2017;7(1):47-50
Desmoplastic small round cell tumour (DSRCT) is a very rare malignant tumour which commonly presented as an
intraabdominal tumour. It has a distinct histological and immunophenotypic characteristic which differentiates it
from other types of small blue cell tumour such as Ewing’s sarcoma, primitive neuroectodermal tumour,
neuroblastoma and malignant mesothelioma. Apart from the abdomen, it may also originate from other region of the
body including the reproductive organs.
Neoplasms
7.Malignant mixed mullerian tumor: A case series
Carla Lenice Lee ; Ana Victoria V. Dy Echo
Philippine Journal of Obstetrics and Gynecology 2018;42(1):23-29
Uterine carcinosarcoma, also known as malignant mixed mullerian tumor (MMMT) is a rare and aggressive malignancy. It is the only type of uterine carcinoma with both an epithielial-derived carcinoma and a mesodermal-derived sarcoma. Classically, they have been considered as a soft tissue sarcoma, however, recent studies ascertain the pathogenesis of carcinosarcomas as to that of a metaplastic transformation of a carcinoma to give rise to a sarcomatous component. With the paradigm shift on the pathogenesis of disease, treatments have been aligned to follow protocols used in aggressive uterine carcinomas and are in further evaluation for its applicability to the aforementioned carcinosarcoma. This paper presents three cases of MMMT diagnosed in a Private Tertiary Hospital from October 2015 to February 2017. Among the three cases, two cases underwent endometrial sampling with results suggestive of MMMT and one case with an intraoperative frozen section done revealing carcinosarcoma. All cases underwent extrafascial hysterectomy with bilateral salpingo-oophorectomy (EHBSO) and bilateral lymph node dissection (BLND). Post-operatively, two of the cases underwent adjuvant chemotherapy and are currently alive. The one case that did not receive adjuvant chemotherapy succumbed to the disease eight months after diagnosis. With the high propensity of MMMT to metastasis, relapse and recurrence, it is then imperative that all cases are properly managed.
Neoplasms
8.Scintigraphic patterns of bone metastases in commonly encountered malignancies
Nicole Patricia A Hui ; Angelo 0. Martinez
The Philippine Journal of Nuclear Medicine 2018;13(1):23-27
Introduction:
Bone scan is the modality of choice for evaluation of bone metases in asymptomatic patients primary malignancy. The distribution and pattern of bone metases in prostate, breast, and lung malignancies are investigated using bone scan results. This could aid future interpretation of bone scans and narrow down the differential diagnoses by establishing the likely regional location of metastatic bone disease in commonly encountered malignancies.
Materials and methods:
Chart review of a total of 411 patients with histologically proven malignant disease, who underwent bone scan in the Division of Nuclear Medicine of the Philippine Heart Center for the first time from October 2013 to October 2016, was conducted.
Results:
Out of 411 patients, 149 had metastatic bone disease; 42 (28.2%) had lung cancer, 26 (17.4%) had prostate cancer, 60 (40.3%) had breast cancer, while the remaining 21 (14.1%) had other primary malignancies. Majority of the lessions were multiple and were found in the ribs, vertebrae and pelvic bones for lung cancer; ribs, lower thoraric and lumbar vertebrae, and pelvic bones for prostate and breast cancer.
Conclusion
There was no scintigraphic pattern attributable to a particular malignancy but rather, sites of predilection were observed in this study. The top 3 regions of distribution of bone metasis were as follows: for lung cancer, 1. ribs, 2. vertebrae, 3. pelvic bones; for prostate cancer,1. lower thoracic and lumbar vertebrae, 2. pelvic bones; 3. ribs; for breast cancer, 1. lower thoracic and lumbar vertebrae, 2. ribs, 3. pelvic bones. Involvement of the long bones wasw highest among lung and prostate cancers; whereas metasis to the sternum was most commonly seen in breast cancer.
Neoplasms
9.Hepatic Cystadenocarcinoma presenting as an ovarian new growth in a 65‐year‐old female: Case report
Stephen Matthew B Santos ; Dulce De Castro ; Joffrey S Betanio ; Walter Batucan
Southern Philippines Medical Center Journal of Health Care Services 2021;7(1):1-6
Biliary cystic tumors (BCT), which include the subgroups biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC), affect 5 to 10% of the global population. BCTs are solitary, multiloculated cysts that are usually intrahepatic in location. BCACs are rare tumors that arise from the malignant transformation of BCA. The presentation of BCT often mimics simple hepatic cysts and other hepatic cystic lesions making diagnosis difficult. With the recent advances in medical imaging, BCTs have been diagnosed more often. Patients with BCT are often asymptomatic. When symptoms are present, however, patients usually manifest with abdominal pain and distention. Given the high risk of recurrence, complete surgical resection by formal hepatic resection or enucleation is the best treatment of choice for patients. We present a case of a 65-year-old female who came in due to a four-year history of an enlarging abdomen. She was initially treated, preoperatively, as a case of ovarian new growth but was later managed as hepatic cystadenocarcinoma.
Neoplasms
10.Melanotic neuroectodermal tumor of infancy
Anjelane M. Enriquez ; Jose M. Carnate Jr.
Philippine Journal of Otolaryngology Head and Neck Surgery 2011;26(1):51-54
A case of melanotic neuroectodermal tumor of infancy (MNETI) is presented. The salient histopathologic features of this unusual neoplasm are discussed including post-chemotherapy morphologic changes.
Neoplasms