The layout problem involves finding the best arrangement of physical components of the service system possible within the time, cost, and technology constraints of the situation. And the layout problem can be a very complex system design problem requiring the most sophisticated lay system analysis and design tools in order to develope satisfactory layout solutions. The objective of this layout study is to reorganize service rooms for minimizing overall patient's moving distance. In solving the service room layout problem, there exist a number of constraints on the building facilities in current location. All other service rooms can be moved if layout analysis indicates it would be beneficial. The first step is to analyze records in order to determine the number of trips made by patients between departments in two months. And a number of layout cases developed as methods to a good service room layout. The result is shortened total patient's layout distance of 252,880 meters.
Humans

The author examined expression of tumor-related antigens, such as p53 tumor supressor protein, c-myc, TGF-alpha, and TGF-beta proteins in 75 cases of surgically resected epithelial ovarian tumors. Peroxidase immunohistochemistry was used to determine the frequency of expression, the relationship among expression of these antigens and histopathological spectrums, and clinical stage, and their potential prognostic significance. The results are summarized as follows. A positive correlation was found between expression of p53(P=0.02), c-myc(P=0.03), and TGF-alpha(P=0.001) and histological degrees of malignancy(benign, borderline, or malignant) in epithelial ovarian tumors. A significant correlation was found between expression of p53 and histological degrees of malignancy in serous ovarian tumors(P=0.003) and mucinous tumors (P=0.049). A significant correlation was also found between expression of c-myc and the histological grade of serous carcinomas(P=0.02). A correlation between expression of these antigenic proteins and clinical stage of epithelial ovarian tumors was not demonstrated. Expression of p53 and c-myc was closely correlated with expression of TGF-alpha irrespective of the histological degrees of malignancy and type of epithelial ovarian tumors(0.4 < or = K < or = 0.7). The results of this study support the ideas that expression of c-myc and TGF-alpha might be a useful prognostic indicator in human ovarian carcinomas, and expression of p53 could be another indicator of prognosis, as the expression of p53 is characteristic in that the expression is mostly seen in invasive ovarian carcinomas.
Humans

No abstract available.
Humans

The authors studied the effect of recession of superior rectus muscle combined with anterior transposition of the inferior oblique muscle for DVD. Superior rectus muscle was tecessed by 4.0-4.5mm combined with antetior transposition of IOM on 26 eyes in 16 patients with 15 +/- 25 delta DVD from March 1991 to September 1995. In all cases we have done transposition of the IOM to just temporal insertion of IRM. The eyes, which have the amount of DVD were less than 20 delta, received 4.0mm recession of SRM, the ones and which have the amount of DVD were more than 20 delta, received 4.5mm recession of SRM. Averaged reduction of DVD in 4.0mm group was 14.5 delta, and in 4.5mm group was 17.6 delta. As for post operative complication, only mild upgaze limitation was abserved in all cases. Recession of SRM combined with anterior transposition of IOM can correct moderate degree of dissociated vertical deviation and this method is relatively simple than other procedure.
Humans

No abstract available.
Humans

No abstract available.
Humans

Extended pyelolithotomy was performed in two patients who had renal stones which were considered to be difficult to remove by ordinary pyelolithotomy. The operative technique was relatively simple and easy, and uneventful recovery followed in all cases.
Humans

No abstract available.
Humans

DFDBA(Decalcified freeze-dried bone allograft) is one of the allograft materials for periodontal bone regeneration. DFDBA provides an osteoconductive surface and osteoinductive factors. Therefore, DFDBA have been used successfully to regenerate the attachment apparatus during periodontal treatment. But recent studies was reported that wide variations in commercial bone bank preparations of DFDBA do exist, including the ability to induce new bone formation. DFDBA was experimental materials that was recovered, processed, tested, shipped and invoiced through Musculoskeletal Transplant Foundation. MTF(Musculoskeletal Transplant Foundation) is the world largest, non-profit, AATB(American Association of Tissue Banks) accredited tissue bank. The objective of this study was to determine the effects of serial dilutions of a DFDBA on human fetal osteoblastic cell proliferation and their potential to form and mineralize bone nodules. Human fetal osteoblastic cell line(hFOB 1.19) was cultured with DMEM and SSE(1microgram/ml, 10microgram/ml, 100 microgram/ml, 1mg/ml) at 34degrees C with 5% CO2 in 100% humidity. Cell proliferation was significantly increased at 1mg/ml, 100microgram/ml, 10microgram/ml, 1microgram/ml, 100ng/ml, 10ng/ml, 1ng/ml of DFDBA after 5 days incubation (p<0.05). Alkaline Phosphatase(ALP) level was significantly increased in 100ng/ml, 10ng/ml, 1ng/ml of DFDABA(p<0.05). A quantified calcium accumulation was significantly increased at 1ng/ml, 10ng/ml of MTF(p<0.05). These results indicated that DFDBA has an inductive effect on bone formation in vitro.
Humans

The purpose of this study was to investigate the effects of ICB(Irradiated frozen allogenic bone, Rocky Mountain Tissue Bank, USA) and MTF(Decalcified freeze-dried bone allograft, Musculoskeletal Transplant Foundation, USA) on the cell proliferation and differentiation of human fetal osteoblasts. Human fetal osteoblasts (hFOB1) were cultured with 10 ng/ml of ICB and MTF. The negatvie control group was cultured with DMSO and positive control group was cultured with BMP (2 ng/ml). MTT was performed to examine the viability of the cell, and alkaline phosphatase activity was analyzed to examine the mineralization. Calcium accumulation was also evaluated. ICB and MTF did not increase the rate of the cellular proliferation of hFOB1s while they enhanced ALP and calcium accumulation. The expression of osteocalcin (OC) and bone silaloprotein (BSP) increased in hFOB1 treated with ICB and MTF (10 ng/ml). These results suggest that ICB and MTF stimulate osteoblastic activity of the hFOB1.
Humans