Depression is a common mental disease,characterized by a high suicide rate and social burden.Integrated traditional Chinese medicine (TCM) and western medicine will be a major mean of clinical treatment in the future.In the clinical research,integrated TCM and western medicine is recommended by improving curative effects and reducing adverse reactions.Research on action mechanism will be the main direction in ahead.The application of neuroimaging,genomics,neurochemistry and metabonomics can explore and expound the mechanism of depression treatment by integrated TCM and western medicine.This paper summarized both clinical and basic research on depression treated by integrated TCM and western medicine in recent years,which may contribute to the development of integrated TCM and western medicine in mental diseases.

Objective To evaluate the lipid-lowering effect of 10 mg policosanol versus an equal dose of atorvastatinin patients with dyslipidemia.Method Databases such as VIP,Wanfang,CNKI,Cochrance Library,PubMed,Web of Science and EMBASE were searched for random control trials(RCT) and controlled clinical trials (CCT) of 10 mg policosanol versus an equal dose of atorvastatinin their lipid-lowering effects.The quality was assessed by Cochrance Handbook 5.1.0 or Newcastle-Ottawa scale (NOS).The study related data were analyzed statistically with RevMan 5.2 software.4 RCTs were selected.257 patients were included in the trials.130 cases were in 10 mg policosanol group and 127 cases belonged to 10 mg atorvastatin group.Results Results of Meta-analysis show that TC[SMD=0.84,95%CI(0.41,1.27),P=0.000 1] and LDL-C[SMD=0.68,95%CI(0.28,1.09),P=0.001] were reduced more effectively in 10 mg atorvastatin group than in 10 mg policosanol group.HDL-C[SMD=0.27,95%CI(0.02,0.51),P=0.03] was elevated more in 10 mg policosanol group than 10 mg atorvastatin group.Both groups showed no statistic difference(P=0.42) in TG [SMD=0.10,95% CI:(-0.41,0.35),P=0.42].Conclusion The lipid-lowering efficacy of 10 mg atorvastatin is better than equal dose of policosanolin patients with dyslipidemia.Dose increase of policosanol should be considered to ensure the efficacy when policosanol was used tore place atorvastatin therapy.This study had some shortcomings, such as limited study numbers and small sample size.The reliability of this study should be verified from high-quality,multi-center RCTS with large samples.

From the perspective of law-and-economics, this paper analyzed the characteristics between medical workplace and other workplace in terms of public safety liability, risk identifiability and preventability. Then it went on to explore the costs structure incurred by medical violence, namely personal costs of victims, public safety cost, risk prevention cost and service supply cost. A law-and-economics optimal penalty model is then developed based on the benchmark of crime of violence free of social cost, and by incorporating the social cost of medical violence. And it is found that an upward deflection of the crime cost curve sharply drives up the optimal penalty corresponding to various levels of violence, and lowers the threshold violence constituting criminal offence, thus balancing the social costs borne by the public for medical violence.

Traditional mindset in anti-medical violence legislation tends to divert the responsibility to prevent medical violence to the party of the lowest costs, a design of obvious loopholes in reducing medical violence occurrence. By combining the legal liability and penalty adjustment to counter medical violence crimes, the US, Australia and South Korea are trying to match the private cost of victims and its social cost with the punishment of crime law. In this sense, China should highlight the nature of public safety of medical service, zero tolerance report and optimal punishment to medical violence crimes. This approach can take place of the existing incentive mechanism featuring violent conflicts, being conducive to building a safe and harmonious doctor-patient relationship.

Objective To observe the impact of individualized diet intervention on diet therapy compliance of patients with diabetes mellitus. Methods All of 180 patients with diabetes mellitus were randomly divided into the intervention group and the control group. The intervention group was treated with conventional treatment and care. While in the control group,the individualized nutrition intervention therapy was used together with conventional treatment and care. After six months,the differences of diet therapy compliance and metabolism indexes between the two groups were com-pared and analyzed. Results Compared with the control group, there was higher compliance of diet therapy in the in tervention group (P<0.01). The levels of glycemia, triglyceride, cholesterol, LDL-C and HbAlc in the intervention group were better than the control group,there was significant difference(P<0.01). Conclusion Individualized nutrition intervention therapy could improve the diet therapy compliance of patients with diabetes mellitus, and could also im-prove indexes of glucose and lipid metabolism.

Objective To observe the clinical efficacy and safety of Osteoset-T in the treatment of elderly patients with chronic osteomyelitis.Methods A total of 58 elderly patients with chronic osteomyelitis were randomly divided into control group and treatment group with 26 cases per group.Two groups were treated with debridement.After debridement,control group was given gentamicin bone cement (4 mg · g-1) filling the cavity,the treatment group was given Osteoset-T (4％ Tobramycin)filling the cavity.The clinical efficacy,lysozyme (LZM),C reactive protein (CRP) and adverse drug reactions were compared between the two groups.Results After treatment,the total effective rates in treatment and control groups were 88.46％ (23/26 cases) and 65.38％ (17/26 cases) with significant difference (P ＜ 0.05).After treatment,LZM in treatment and control groups were (22.45 ± 1.78),(18.54 ±1.32) μg · L-1;CRP in treatment and control groups were (1.58 ± 0.22),(3.86 ± 0.43) mg · L-1,with significant differences (P ＜ 0.05).The adverse drug reactions in treatment group were local infiltration fluid,which in control group were local infiltration fluid and delayed wound healing.The incidences of adverse drug reactions in treatment and control groups were 3.85％ and 7.69％ without significant difference (P ＞0.05).Conclusion Osteoset-T has a definitive clinical efficacy in the treatment of elderly patients with chronic osteomyelitis,which can improve the levels of LZM,reduce the levels of CRP,without increasing the incidence of adverse drug reactions.

Objective To explore the breakthrough point and working mode of clinical pharmacists participating in clinical work of oncology de-partment.Methods Clinical pharmacists provided personalized service for doctors , nurses and patients by participating in ward round , reviewing the management system and standard process of chemotherapy medica-tion, helping the software engineers write the management module of chemotherapy medication , summarizing knowledge points from medicine instructions and editing the handbook of high -risk drug , etc.Results and Conclusion Clinical pharmacists played an important role and obtained obvious effect in promoting chemotherapy medication safely and effectively.Promoting safe and rational administration of chemotherapy medication can serve as the starting points and working mode of clinical pharmacists participating in clinical work.

Objective To explore the effect of continuous care family visiting on disease uncertainty and psychological conditions in non-dialysis chronic renal failure patients .Methods Totals of 120 non-dialysis chronic renal failure patients admitted to our department from July 2011 to June 2013 were selected.In accordance with the principle of randomized controlling , patients were divided into observation group and control group, with 60 cases in each.The control group received conventional family supervision , while the observation group underwent continuous care family visiting in addition to traditional family supervision . The illness uncertainty and psychological conditions of two groups were assessed and compared before and after the intervention .Results Before the intervention , disease uncertainty and psychological conditions of the two groups were not significantly different (P>0.05).After the intervention, the scores of sense of uncertainty, complexity, unpredictability, lack of disease-related information or inconformity were (35.3 ±5.1), (8.7 ± 3.0), (8.8 ±3.5) and (12.5 ±2.8), which were significantly better than those in the control group (t=11.70,11.10,10.70,8.21,respectively;P <0.05).Before the intervention, the scores of anxiety and depression of the two groups were not significantly different (P>0.05).After the intervention, the scores of anxiety and depression were (42.1 ±5.8) and (41.3 ±5.6) in the observation group, which were significantly lower than those in the control group (t=3.440, 5.740, respectively;P<0.05).Conclusions Continuous care family visiting cannot only significantly alleviate the uncertainty of illness in non -dialysis chronic renal failure patients, but also improve their mental condition and quality of life , and enhance their motivation and adherence to treatment .

[Objective]We select the cases of the famous doctor RUAN Huaiqing in Zhejiang, hoping to provide reference for the modern clinical treatment of depression.[Methods]In view of the collation and study of ancient famous medical records,this article analyzes the cases about depression syndrome in Ruan Shi Yi An,including the gynecologic and miscellaneous diseases medical cases,and evaluates the treatment experience of them at the same time. [Results]RUAN Huaiqing considers the location of this disease belonging to the three viscera of heart, liver and spleen. For the most part, he uses Yueju Wan,Guipi Tang and Xiaoyao San as a treatment, and pays more attention to emotional adjustment.[Conclusion] RUAN Shi Yi An can reflect the clinical experience of RUAN Huaiqing,and he inherited the academic viewpoints and experience of diagnosis and treatment of the former. The discussion and treatment experience of RUAN Huaiqing about depression syndrome, is worthy learning and being applied to clinic.

Objective:To explore the expectations of different groups, including the vice president in charge of hospital infection, hospital infection management professionals, nursing managers, and department directors, on the core competence of head nurses in hospital infection prevention and control.Methods:Using the phenomenological research method, purposive sampling method was used to conduct in-depth semi-structured interviews with 25 interviewees from 5 tertiary general hospitals in Hangzhou City, Zhejiang Province, including vice presidents in charge of hospital infection, hospital infection management professionals, nursing managers, department directors, clinical staff and logistics supervisors. A total of 25 interviewers conducted in-depth semi-structured interviews, and the collected data were analyzed by Colaizzi′s 7-step analysis method.Results:Four themes were extracted, including the expectation of the head nurse′s infection control target management ability, the expectation of the head nurse′s infection control professional knowledge ability, the expectation of the head nurse′s infection control clinical practice ability, and the expectation of the head nurse′s infection control influence.Conclusions:In the sensory control management of the department, head nurses should have strong infection control target management ability, continue to learn and update the infection control knowledge and concepts, improve the clinical infection control practice ability, properly authorize, reasonably motivate and improve the infection control management. Team execution ability, create a good atmosphere of department sense control, and promote the development of infection control work.