Sepsis is the main cause of infection death in intensive care unit(ICU),and thrombocytopenia is a common complication.Persistent thrombocytopenia is a marker of poor prognosis in critically ill patients.Sepsis-associated thrombocytopenia(SAT)involves a variety of pathophysiological mechanisms,and platelets play a key role in coagulation and inflammatory response.Platelet count(PLT)can not only predict the prognosis of patients with sepsis,but also be used as a therapeutic target to improve the success rate of rescue in patients with sepsis.This article will review the pathophysiological mechanism,prognosis and treatment of platelets in septic patients.

Objective? To investigate the risks of malnutrition in patients with lung cancer during chemotherapy and to analyze their influencing factors. Methods? The inpatients with lung cancer receiving chemotherapy in the Department of Respiratory Medicine, Enze Medical Center from September 2017 to August 2018 were selected by convenient sampling. The 112 patients were divided into groups according to Nutrition Risk Screen (NRS) 2002. Their general information, diet and malnutrition risks were investigated successively. Logistic regression analysis was used to identify the influencing factors to malnutrition risks of the patients during chemotherapy. Results? Totally 112 patients completed the study. 28 of them showed no risk of malnutrition, while 84 had risks of malnutrition. There were statistically significant differences in age, place of residency, household monthly income, nutritional management, tumor staging, intake of protein and fat, nausea, emesis and diarrhea between two groups with different nutrition conditions(P＜ 0.01). Logistic regression analysis revealed that age, place of residency,monthly income, nutritional management, tumor staging, intake of protein, nausea, emesis and diarrhea were the risk factors of malnutrition in patients with lung cancer during chemotherapy. Conclusions? Patients with lung cancer are at high risk of malnutrition during chemotherapy. Age, nutritional management, tumor staging, intake of protein, nausea, emesis and diarrhea are the risk factors of malnutrition in patients during chemotherapy. Effective nutritional management intervention shall be made for patients as early as possible, so as to reduce the incidence and worsening of malnutrition and improve patients' effects and quality of life.

Objective To investigate the prevalence of and influencing factors for atopic dermatitis (AD)in children aged 1-7 years in Shenzhen city,and to analyze difference in diagnostic results between two diagnostic criteria.Methods From December 1st 2013 to March 1st 2014,a questionnaire survey and physical examination were conducted to investigate the prevalence of AD in children aged 1-7 years in Shenzhen city.Results A total of 1 504 children were enrolled into this study,including 716 males and 788 females.Based on the clinical diagnosis by experienced dermatologists,the prevalence of AD was 11.84％ (17811 504) in total,11.73％ (84/716) and 11.93％ (94/788) in males and females,respectively,and there was no significant difference in the prevalence of AD between males and females (x2 =0.01,P ＞0.05).Based on the Williams' diagnostic criteria,the prevalence of AD was 3.92％ (59/1 504) in total,and 4.05％ (29/716) and 3.81％ (30/788) in males and females,respectively.Premature birth was a risk factor for the occurrence of AD (x2 =5.43,P ＜ 0.05).Conclusions The prevalence of AD is evidently increased among children aged 1-7 years in Shenzhen city,and premature birth is a risk factor for AD.Missed diagnosis will be reduced based on clinical diagnosis by experienced dermatologists.

Objective:To investigate the clinical value of eosinophil count in predicting the progression and prognosis of COVID-19.Methods:In this retrospective cohort study, 115 patients confirmed COVID-19 were enrolled in Taizhou Public Health Medical Center, Taizhou Hospital, Zhejiang Province, China, from January 22, 2020 to February 12, 2020. The subjects were divided into non-severe ( n=90) and severe ( n=25) groups, of which medium age was 46 years old, including 65 male and 50 female subjects. The value of eosinophil count in reflecting the severity of COVID-19 was tested with a receiver operating characteristic curve (ROC) analysis; Correlation analysis of eosinophil count at the admission with length of stay (LOS) were studied. GraphPad Prism6 and SPSS 19.0 statistical software were applied to data analysis. Differences among groups were analyzed with the Mann-Whitney U test. Results admission, Eosinophil counts of severe patients were significantly lower than those of non-severe ( P<0.001). The eosinophil count remained below normal for 1-7 days after admission and rose to normal by 21 to 28 days; The area under the ROC curve (AUC) of eosinophil to COVID-19 severity was 0.781(95% CI:0.693-0.869); The Eosinophil count at admission was negatively correlated with the patient's length of stay. Conclusions:The decrease of Eosinophil count can serve as a risk factor for auxiliary diagnosis in severe COVID-19 patients. The dynamic monitoring of eosinophils is useful for prognostic purposes.

Objective To explore the influence of evidence-based nursing on the comfort level of patient with indwelling urethral catheterization.Methods Total of 300 patients with indwelling urethral catheterizationwere divided into control group and observation group according to random number table method,with 150 patients in each group,respectively.Common nursing method wasadoptedto the control group,while evidence-based nursing interventionwas applied for observation group.Relevant literature was retrieved to select the optimal nursing evidence according to the clinical experience and patients' demand,to develop specific nursing planand assess the comfort level of the patients in the two groups according to pain level,frequent urination,urgent urination,micturition desire.Results In the control group,5 patients' comfort was in level 0 ; 65 patients' comfort was in level Ⅰ; 80 patients' comfort was in level Ⅱ; 0 patients' comfort was in level Ⅲ.In the observation group,69 patients' comfort was in level 0; 47 patients' comfort was in level Ⅰ; 34 patients' comfort was in level Ⅱ; 0 patients' comfort was in level Ⅲ.The difference of comfort level of the patients in the two groups had statistical significance (U =7.42,P ＜ 0.01).Conclusions The application of evidence-based nursing intervention can improve the comfort level of patient in indwelling urethral catheterization during the retention period.