With the rapid development of modern society, high energy injury has greatly increase as compared with the past, and the number of trauma patients seeking medical treatments has risen year by year. Trauma emergency medicine has become the reflection of the service level and medical quality of medical institutions, as well as the hospital administrators' attention and concern to this discipline. This paper aims to elaborate the status and role of emergent medicine of trauma in the development of hospitals, to review the significant experience in the construction and reform of Tianjin Trauma Emergence Center, and put forward the prospect of future disciplines and center construction in combination with the practice.

Objective To explore the bioactive constituents of Shufeng Jiedu capsule and its potential mechanism in the treatment of acute lung injury(ALI)via network pharmacology,bioinformatics analysis and molecular docking methods.Methods The bioactive constituents of Shufeng Jiedu capsule were searched from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)database.The putative targets of Shufeng Jiedu capsule were obtained from TCMSP and Swiss Targets Predicion website.Targets associated with ALI were obtained from 5 disease target prediction databases,including DisGeNET,GeneCard,Online Mendelian Inheritance in Man(OMIM),Therapeutic Target Database(TTD),and National Center for Biotechnology Information(NCBI).The intersecting targets between drug-related targets and disease-related targets were defined as potential therapeutic targets of Shufeng Jiedu capsules in the treatment of ALI.A regulative network among drug,ingredients and potential therapeutic targets was explored,and it was further visualized by Cytoscape 2.6.1 software.The key bioactive ingredients and core therapeutic targets were speculated according to the topological parameters.Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis was applied to the potential therapeutic targets.AutoDock Vina 1.1.2 was used to perform molecular docking and the docking results were visualized by PyMol software.Results A total of 170 bioactive constituents of Shufeng Jiedu capsule were obtained from TCMSP database,and 104 potential therapeutic targets of ALI were obtained in the present study.Quercetin,Luteolin,Wogonin,Kaempferol,and Acacetin were taken as putatively key constituents via the drug-ingredients-targets network.Prostaglandin endoperoxidase 2(PTGS2),nitric oxide synthase 2(NOS2),glycogen synthase kinase-3β(GSK-3β),PIM1 kinase and peroxisome proliferator-activated receptor gene(PPARG)were identified as the hub targets and hypoxia-inducible factor-1(HIF-1)pathway et al was considered as the key pathway of Shufeng Jiedu capsule through KEGG analysis.Molecular docking showed a stable affinity between the key compounds and the hub targets,confirming the accuracy of the network pharmacology screening results.Conclusion The mechanism of Shufeng Jiedu capsule in treating ALI involves multiple active ingredients,therapeutic targets,and signaling pathways,which can provide new ideas for the clinical treatment of ALI.

Orthopedic robots, as intelligent medical devices, have achieved good outcomes in clinical application in some orthopedic surgeries. Artificial intelligence (AI) has played an important role in the development of orthopedic robots due to its powerful capabilities of information processing and decision-making. The developing trends of orthopedic robotics are automation and intelligentization. Since AI has demonstrated great advantages in preoperative planning, an increasing number of researchers have been devoted to AI application in intraoperative navigation by an orthopedic robot. This paper outlines the exploratory efforts in applying AI technology to the intraoperative navigation assisted by an orthopedic robot, describes the advantages of AI in improving accuracy and reducing radiation, and forecasts research prospects in application of AI technology to orthopedic robots based on the current situation.

Periprosthetic fracture of femur is the most common postoperative complication after total knee arthroplasty (TKA). Risk factors for periprosthetic fractures include female sex, osteoporosis/osteopenia, rheumatoid arthritis, osteoarthritis, neuromuscular disease, cognitive disorder, chronic use of corticosteroids, obesity, advanced age, infection, osteolysis around the prosthesis, knee joint ankyloses, notching of the anterior femoral cortex, etc. According to epidemiological research, the incidence of femoral periprosthetic fractures following TKA ranges from 0.3% to 2.5%. Lewis and Rorabeck classifications, the most commonly used classification of periprosthetic fractures of the femur, introduce the concept of prosthesis loosening and emphasize the ecessity of revision surgery. Other classifications include Su typing, Universal Typing System, and Rhee typing, the latest of which is the Kim typing proposed in 2022. Treatment strategies for periprosthetic femoral fractures after TKA include nonsurgical treatment, external fixation techniques, single-plate fixation, double-plate fixation, intramedullary nail fixation, and revision TKA and distal femur replacement. The purpose of this paper is to better guide the prevention and treatment of periprosthetic fractures after TKA by searching and analyzing relevant literature on periprosthetic fractures after TKA.

Objective To investigate the predictive values of serum complement C3, C4 and cholesterol levels in the prognosis of patients with sepsis. Methods The clinical data of all the patients with sepsis admitted to the Department of Critical Care Medicine of the General Hospital of Xinjiang Military Command from January 2015 to January 2017 were retrospectively analyzed. The levels of serum complement C3, C4, cholesterol, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) score, sequential organ failure score (SOFA), etc. were recorded within 24 hours after admission, the patients were divided into survival group and death group according to the 28-day prognosis, and the differences in various indexes between the two groups were compared respectively;the predictive efficacies of C3, C4 and cholesterol levels in the prognosis of sepsis patients were evaluated by plotting receiver operating characteristic curves (ROC). Results Finally, 120 patients with sepsis were enrolled, including 57 patients in the survival group and 63 patients in the death group. Compared with the survival group, the APACHE Ⅱscore and the SOFA score of the death group were increased significantly (APACHE Ⅱ score: 20.29±5.90 vs. 15.32±5.98, SOFA score: 7.62±3.11 vs. 5.16±2.50, both P < 0.01), however, serum C3, C4 and cholesterol levels were obviously decreased [C3 (g/L): 0.67±0.22 vs. 0.82±0.24, C4 (g/L): 0.17±0.05 vs. 0.20±0.06, cholesterol (mmol/L): 2.77±1.23 vs. 3.46±1.02, all P < 0.01]. ROC curve analyses showed: each of the following items, complement C3, C4, and cholesterol, alone predicting the prognosis of sepsis patients, the area under ROC curve (AUC) and 95% confidence interval (95%CI) were as follows: AUC = 0.680 (95%CI = 0.583-0.777, P = 0.001), AUC =0.657 (95%CI = 0.560-0.754, P = 0.003), and AUC = 0.711 (95%CI = 0.619-0.804, P < 0.001) respectively; when complement C3, C4 and cholesterol combination to predict the prognosis of patients with sepsis, the resulting predictive value was better than the predictive value results obtained by each one of the items or each combination of any two of them (the AUC of C3+C4+cholesterol was 0.725, 95%CI = 0.633-0.817, P < 0.001; the AUC of C3+C4 was 0.697,95%CI = 0.603-0.791, P < 0.001; the AUC of C3 + cholesterol was 0.718, 95%CI = 0.626-0.811, P < 0.001; the AUC of C4+cholesterol was 0.722, 95%CI = 0.629-0.815, P < 0.001). Conclusion Using combination of serum complement C3, C4 and cholesterol levels to predict the prognosis of patients with sepsis may obtain important predicting value, that can provide a reference to clinical doctors.

Objective:To explore the effects of foot intrinsic muscle strengthening training on knee function and gait in patients after total knee arthroplasty(TKA). Method:Eighty-two patients with unilateral severe knee osteoarthritis were randomly divided into treatment group(n=41)and control group(n=41).The control group received routine rehabilitation treatment after knee re-placement,while the treatment group received additional foot intrinsic muscle strengthening exercises alongside standard rehabilitation.Functional outcomes were evaluated preoperatively and at 12 weeks postoperatively us-ing the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC).Balance function was as-sessed using the Berg Balance Scale(BBS)and the Modified Falls Efficacy Scale(MFES).Gait analysis was per-formed using portable intelligent gait analysis equipment. Result:After 12 weeks of rehabilitation,the study group showed significantly better outcomes in WOMAC scores,MFES scores and BBS than those in the control group(P＜0.05).The single leg support time,step speed and step length of the operative limb in the treatment group were significantly improved compared with the control group(P＜0.05). Conclusion:Twelve weeks of foot intrinsic muscle strengthening exercises post-TKA can improve physical func-tion,balance ability,and gait in patients.

Traumatic spinopelvic dissociation is trauma-induced complete separation of the pelvis and spine anatomy. It is characterized by longitudinal fracture lines on both sides of the sacral bone with transverse fractures, multiplane unstable fractures, more common in high-energy violent injury, more combined injuries, high incidence of sacral nerve injury, improper treatment can easily lead to fracture re-displacement, painful deformity healing, secondary nerve injury, dysfunction and other adverse consequences. The difficulty in the surgical treatment of traumatic spinopelvic dissociation lies in the reduction and fixation of fractures. Among them, it is still controversial whether the reduction method of fracture should be open reduction or closed minimally invasive reduction, the internal fixation should be simple sacroiliac screw or plate, iliolumbar fixation or triangular fixation, and whether the sacral nerve injury needs direct decompression. With the improvement of the understanding of spinopelvic dissociation injuries and clinical application of closed minimally invasive reduction technology, minimally invasive sacroiliac screws, iliolumbar fixation, and triangular fixation are increasingly used in clinical treatment, postoperative wound complications are significantly reduced, patient function prognosis is good, indirect decompression of the injured sacral nerve after fracture reduction helps to restore nerve function, but when the fracture displacement is large with a narrow sacral canal and the nerve is compressed by the fracture or free bone mass, direct decompression by laminectomy is recommended.

Closed reduction percutaneous screw fixation offers significant biological and biomechanical advantages and can be employed independently for the surgical treatment of pelvic acetabular fractures, as well as serving as a complementary method to open reduction internal fixation. The osseous fixation pathway (OFP) constitutes the anatomical foundation for the minimally invasive approach to pelvic and acetabular fracture management. The pelvis's OFP can be categorized into anterior, middle, and posterior parts. The anterior OFP encompasses both the superior pubic/anterior column and inferior pubic OFPs. The former is primarily utilized for addressing transverse and T-shaped acetabular fractures, as well as anterior column and superior pubic fractures. The latter is predominantly applied to inferior pubic fractures. The middle OFP includes the anterior inferior iliac spine to the posterior iliac crest (LC-II) OFP, the gluteus medius column OFP, and the iliac crest OFP. The LC-II OFP is primarily designated for pelvic crescent, iliac wing, and select high anterior column acetabular fractures. The gluteus medius column OFP is used for the treatment of some iliac fractures or acetabular fractures. And the iliac crest OFP is used for the treatment of simple iliac wing fractures or acetabular fractures involving the iliac crest. The posterior OFP includes the posterior column of the acetabulum OFP, sacroiliac OFP, and sacral OFP. The posterior column of the acetabulum OFP is used for the treatment of acetabular fractures involving the posterior column; the sacroiliac OFP is mainly utilized for a range of pelvic injuries, including pelvic rotational or vertical unstable pelvic injury, sacroiliac dislocation or fracture dislocation; open injury of the posterior ring of the pelvis with relatively mild contamination; elderly sacral (incomplete) fractures; residual gap at the end of sacral fracture after pubic symphysis and plate internal fixation; certain traumatic spinopelvic dissociation ; in combination with lumbopelvic fixation for the treatment of pelvic fractures with lumbosacral junction injury. Sacral OFP is advised for treating bilateral sacroiliac dislocation and certain crescent-like pelvic fractures; bilateral sacral fractures; sacral fractures involving Denis III zone, osteoporotic sacral incomplete fractures. The pursuit of minimally invasive treatment modalities for pelvic and acetabular fractures comes with challenges. A comprehensive understanding of OFP morphology and intraoperative imaging, coupled with a commitment to enhancing fracture reduction quality and surgical proficiency, is imperative for the precise management of such injuries.

The development of modern science and technology continues to promote the advancement of surgical methods, the era of surgical surgery led by robots has arrived. Orthopaedic positioning robot is a kind of auxiliary treatment equipment to realize surgical planning by means of spatial mapping of target images. It is composed of movable robotic arm, optical tracking device and surgical planning navigation system. During the operation, the path navigation of surgical instruments can be planned and implemented according to the predetermined procedure, and the precise placement of orthopedic internal fixation can be completed with the participation of the surgeon. It is mainly used in trauma orthopaedics, joint replacement and spine surgery fields. It has clinical advantages such as accurate operation, stable performance and good repeatability. Robot assisted minimally invasive pelvic acetabular fracture surgery is mainly realized by assisted placement of the LC-II screw, sacral iliac screw, iliac lumbar triangular fixation, iliac lumbar fixation, acetabular anterior column screw, acetabular posterior column screw, Magic screw and other osseous fixation pathway screws. It has the advantages of relatively simple operation, small systematic error, accurate spatial positioning and safe screw insertion. The clinical introduction of robot-assisted surgery provides effective solutions and advanced technical supports for optimizing the surgical treatment of pelvic acetabular fractures and promoting the enhanced recovery after surgery. The continuous improvement of the application level of robots has created favorable conditions and technical support for promoting the development of intelligent, individualized, minimally invasive and precise treatment of pelvic and acetabular fractures.

Objective To analyze the expression and significance of BCAS3 and RFX3 proteins in mac-rophages from gout stone tissues.Methods Thirty gout stone excision specimens in this hospital from April 2019 to December 2022 were collected as the experimental group,and during the same period 25 specimens of synovial hyperplasia accompanied by foreign body giant cell reaction after joint replacement and 5 specimens of fat necrosis accompanied by macrophage hyperplasia served as the control group.The blood uric acid level of the control group was normal.Immunohistochemical staining was applied to conduct CD68,CD163,BCAS3 and RFX3 antibodies staining in all specimens.CD68 and CD163 were used to locate macrophages in tissues. The expression levels of BCAS3 and RFX3 in macrophages were detected.The expressions of the two antibod-ies and their correlation with age,sex and blood uric acid level were analyzed.The receiver operating character-istic (ROC) curve was used to evaluate the diagnostic value of the both on gout.Results The expression lev-els of BCAS3 and RFX3 in the experimental group were significantly higher than those in the control group (P<0.05).The BCAS3 and RFX3 protein expression levels in the control group had no statistical difference between the different sexes (P>0.05).The expression level of BCAS3 protein in the experimental group was positively correlated with the RFX3 protein expression (P<0.05);the uric acid level in the experimental group was positively correlated with the expression level of BCAS3 and RFX3 protein (P<0.05).The blood uric acid level in the control group had no correlation with BCAS3 and RFX3 protein (P>0.05).The age in the two groups had no correlation with the BCAS3 and RFX3 protein (P>0.05).The area under the curve (AUC),sensitivity and specificity of RFX3 were 0.935,96.55％ and 86.67％ respectively,which were higher than 0.742,70.00％ and 80.00％ of BCAS3.RFX3 had the higher diagnostic value for gout.Conclusion High expression of BCAS3 and RFX3 proteins in macrophages may participate in the pathogenesis of gout.There may be some synergistic promoting effect between the two.The diagnostic value of RFX3 for gout is higher than that of BCAS3.