[Objective] We will sum up the relevant rules of the treatment of such diseases in the Treatise on Fevers by the pathogenesis of Sini Powder for improving the clinical curative effects.s [Method] The article quotes the original text of the Treatise on Fevers and analyzes the related criticisms by the other physicians,analyzes and summarizes the disciplinarian of the pathogenesis of SiNi decoction.By the way,we will present the application of the disciplinarian in the Treatise on Febrile Diseases.[Result] We find that Sini Powder is used to develop the condition of ShaoYin sickness,qi depression conceals the developing direction.So ZHANG Zhongjing eliminated the qi depression to know the developing direction firstly.According to the direction,he decided what was the best therapeutic schedule.[Conclusion] The pathogenesis of Sini decoction is the quintessence of SuiZhengZhiZhi,a thought of the Treatise on Fevers.We should understand and master the quintessence,improve the clinical diagnosis and treatment efficacy.

Physical restraint is a conventional nursing practice at home and abroad. AS the use of physical restraint in the hospital, the risk has been increasingly emerging. Many scholars have already realized the necessity of Restraint Minimization Act and the voices of reducing the using of physical restraint run high constantly. Therefore, this paper would review the status quo of the using of physical restraint, advantages and disadvantages, ethical issue, influencing factors and restraint minimization act domestic and international, so as to provide help and support for further research.

After leaving the ICU, many ICU patients and their families will be affected by the long-term effects of physical, psychological and social dysfunction, which will affect their recovery and quality of life.Therefore, it is necessary to provide follow-up care services for this group. The follow-up of ICU after more than 20 years of development has a positive effect on helping patients and their families cope with various problems after ICU and promoting comprehensive rehabilitation of patients. This article reviews the development of follow-up care after ICU, the follow-up care model after ICU, and the common tools for follow-up care after ICU, which provides reference and basis for follow-up nursing practice in domestic ICU.

Cervical cancer is a common malignant tumor of women,which is caused by human papillomavirus(HPV) infection especially high risk HPV infection(HR-HPV).According to the statistics from the World Health Organization (WHO),the incidence and fatality rate of cervical cancers are obviously rising and getting younger in resent years,which seriously threatens the health of women.In China,the mortality of cervical cancer is the first in the female reproductive tract malignant tumor.Although cervical cancer screening has received more and more attention,which reduces the risk of cervical cancer,it does not prevent the necessary factors of cervical cancer,i.e.the HPV infection.Therefore,effective prevention and treatment methods are urgently needed to control the occurrence and development of HPV infection.Both Chinese and Western medicine have made significant progress in the treatment of persistent HPV infection,and they have own advantages and can complement each other.The combination of Chinese and Western medicine is expected to be an effective way to treat cervical persistent HPV infection.

Tic disorder (TD) is a common neuro-developmental disorders in children during school age. The cause is complex and it can be induced or aggravated by varies of factors such as genetics, exogenous pathogens, and emotions. TD affects children's self-cognition, academic level, and social function, and causes parents to have unhealthy psychological states such as anxiety and depression, and affects family harmony. Therefore, clinical attention should not only be paid to the treatment of this disease, but also to prevention and nursing care. Incubative evil theory is one of the important theories of Traditional Chinese Medicine. This theory can help to treat and prevent diseases. Incubative evil is characterized by no symptoms with spontaneous attack by latent pathogen, but symptoms appearance induced by the pathogen. The pathological process of TD is similar to incubative evil characteristics. This paper discusses the prevention and nursing care of children's tic disorder based on the theory of incubative evil.

Osteoclast is a type of multinuclear giant cell, which plays a role in bone resorption in the homeostasis of bone mass. Excessive bone resorption leads to osteoporosis and other diseases characterized by decreased bone mass. Ca 2+ metabolism plays an important role as a second messenger in the differentiation, migration, fusion and bone resorption of osteoclast. The transient receptor potential vanilloid (TRPV) ion channel is expressed in a variety of cells, including osteoclast. Current studies have found that the TRPV ion channel can participate in the production and bone resorption function of osteoclast by increasing intracellular Ca 2+ concentration and calcium oscillations. This article reviews the relationship between the TRPV ion channel and the changes of Ca 2+ concentration and the potential mechanisms involved in osteoclast activity, so as to provide a reference for further research on diseases characterized by abnormally increased activation of osteoclast in the future.

Diabetic foot ulcers are common in elderly people with diabetes.Ongoing research is aimed at unraveling the complicated molecular mechanisms underlying diabetic foot ulcers.The role of cellular aging in delayed healing of diabetic foot ulcers has been recognized.Analyzing the relationship between cellular aging and diabetic foot ulcers, examining how cellular aging delays the healing of diabetic foot wounds, and identifying treatment methods for the removal of senescent cells and for slowing down cellular senescence will provide new therapeutic targets and strategies for the development of drugs for diabetic foot ulcers.

Small ubiquitin-like molecules(SUMO)regulate the function of a variety of cells by binding to target proteins.SUMO modification plays an important role in embryonic development,including heart,brain,liver,etc.Factors involved in lung development and maturation are regulated by SUMO modification,such as hypoxia-inducible factor,CCAAT enhancer-binding protein α,forkhead box protein M1,vascular endothelial-derived growth factor,and bone morphogenetic protein 4,thus affecting their activities and stabilities.Therefore,the SUMO modification status of target protein is the key to explore the development process of fetal lung.In this paper,we reviewed the research literature of SUMO mediated lung development in recent years,and combined with the research basis of our research group for many years,reviewed the factors regulating lung development and the SUMO status,in order to provide ideas for the study of drugs for effective prevention and treatment of pulmonary dysplasia.

Objective:To explore the effects of probiotics on non-motor symptoms in patients with Parkinson disease through Meta-analysis, so as to provide objective evidence for the clinical practice of probiotics on non-motor symptoms in patients with Parkinson disease.Methods:Randomized controlled trials on probiotics for non-motor symptoms of Parkinson disease were searched in Cochrane Library, PubMed, Embase, Web of Science, China National Knowledge Infrastructure, VIP, Wanfang Data and SinoMed. The search time limit was from the establishment of the database to September 1, 2022. Two researchers independently conducted article screening, data extraction, and quality evaluation, and used RevMan 5.4.1 for Meta-analysis.Results:A total of 543 patients were included in 8 articles. The results of Meta-analysis showed that the clinical efficacy of probiotics on constipation in patients with Parkinson disease [ OR=7.25, 95% CI (2.00, 26.23) , P=0.003], constipation symptoms [ SMD=1.21, 95% CI (0.38, 2.04) , P=0.004], constipation-associated quality of life [ SMD=0.93, 95% CI (0.60, 1.27) , P<0.001], average number of weekly spontaneous defecation [ SMD=0.80, 95% CI (0.42, 1.17) , P<0.001], anxiety [ SMD=0.54, 95% CI (0.28, 0.80) , P<0.001], depression [ SMD=0.73, 95% CI (0.48, 0.97) , P<0.001] and sleep quality [ SMD=0.53, 95% CI (0.16, 0.90) , P=0.005] were better than those in the control group, with statistically significant differences. Conclusions:Probiotics can effectively improve constipation, anxiety, depression, and sleep disorders in non-motor symptoms of Parkinson disease patients.

Objective:To analyze the research status, hot spots and trends in the field of rehabilitation nursing for children with cerebral palsy in China based on the visualization function of CiteSpace software, so as to provide reference for further research on rehabilitation nursing of children with cerebral palsy in China.Methods:Literature related to rehabilitation nursing of children with cerebral palsy was searched from CNKI, Wanfang Database and VIP, and the search period was from the establishment of the databases until June 18, 2023. In this study, CiteSpace 5.8.R3 was used for visual analysis of the literature.Results:A total of 1 092 articles were included, published from 1991 to 2023, and the number of published papers showed an overall upward trend. The distribution of literature among regions and institutions was uneven, and the degree of cooperation was low. Research frontiers included motor function, communication skills and quality of life.Conclusions:The research on rehabilitation nursing of children with cerebral palsy in China is in the development period, and the degree of attention and importance needs to be improved.