Postoperative sensory dysfunction of breast cancer is a common complication after breast cancer surgery,which is main-ly manifested in numbness,pain and hypothyroidism,etc.This article introduced the common sensory impairments and related factors,as well as the evaluation and treatment of sensory dysfunction after breast cancer surgery.

Most of clinicians'researches are investigator-initiated clinical trial.There is a great difficulty in not knowing what to choose.Clinicians can think about the etiology and incidence, treatment effect evaluation, diagnostic methods and prognosis prediction.Clinicians can also find topics from clinical practice, from clinical guidelines, from literature and from different perspectives.If there is no high quality level of research evidence, it can be used as a research topic.

A two-sided market perspective was employed to depict public hospital as a platform,including cross-group network externality,demand complementarities and price discrimination.Knowledge worker framework was employed to depict features of physicians.The paper argued that the public hospital could support autonomy and achievement attributes.The development of organization platform indicates that public hospital should invest more resources in technician exclusively associated to platform,encourage physicians to use platform efficiently,establish a various organizational ecology,and entrust physicians greater governance.

Objective To investigate the value of adenosine triphosphate(ATP)bioluminescence assay for assessing object surface contamination degree in intensive care unit(ICU).Methods 30 groups of high frequency contact object(including ventilator panel,bedside table and computer keyboard)in ICU from January to December 2016 were enrolled for the study. Each object was sampled and evaluated before and after disinfection,and their surface was divided into two areas,whose sur-face contamination degree was evaluated by ATP bioluminescence assay and bacterial culture method that were classified as ATP group and control group.The fluorescence detection value and colony number were compared between two groups be-fore and after disinfection.The correlation between the fluorescence detection value and colony number was analyzed by Pearson correlation in the same sample,and the Kappa consistency test was used for the qualification rates of two detections. Results ①The fluorescence detection value and colony number of ventilator panel,bedside table and computer keyboard af-ter disinfection in two groups were significantly lower than that before disinfection(t=8.107~26.393,all P<0.05).②Pearson analysis result showed that both before and after disinfection,the fluorescence detection value had no significant cor-relation with colony number of ventilator panel,bedside table and computer keyboard(r=0.199~0.338,all P>0.05).③There were no significant differences in the qualification rate between two groups of ventilator panel,bedside table and com-puter keyboard before and after disinfection(χ2=0.000~1.404,all P>0.05).The qualification rate before the disinfection of ATP group and control group were 0 and 8.9%,and that after disinfection were 86.7% and 91.1%,whose Kappa consis-tency test result showed that the Kappa value was 0.776(95%CI:0.575~0.978)>0.75,so the consistency was quite sat-isfied.Conclusion ATP bioluminescence assay could be used as a rapid and handy preliminary screening to assist bacterial culture method to evaluate the object surface contamination in ICU,and the result was satisfactory and it would be worthy of clinical application.

Single-cell RNA sequencing is a method for transcriptome profiling at the single-cell level,and is a hotspot technology in the field of biological research currently.Compared with the common high-throughput RNA sequencing,single-cell RNA sequencing can distinguish the biological differences between single cells,and identify rare cell populations and subpopulations.This review mainly describes the single-cell RNA sequencing method,summarizes current application of this technique in the field of dermatology,and discusses limitations and prospects of this technique.

Objective Studies had suggested that risk of leukemia might be associated with occupational or residential exposures to electromagnetic fields and varied at distance to and level of the exposure or type of occupations. Through pooled analyses, etiologic insight on the associations between exposure and disease might be explained. Methods We carried out a Meta-analysis based on primary data (1980-2010) from 9 studies related to the electric and magnetic fields exposure and acute myeloid leukemia in adults to assess whether the combined results, adjusted for potential confounding, would indicate an association between them. Results In this study the overall estimated OR value was 1.24(95%CI: 1.11-1.37). The odds ratios for exposure categories of 0.1-0.2 μT, ≥0.2 μT, compared with ＜0.1 μT, were 1.17(95%CI: 0.98-1.39) and 1.51 (95%CI: 1.15-1.98),respectively. Conclusion Through employing the alternate cut points, stratification by level of exposure or distance and the relation on different ways of exposure, there appeared consistent evidence of increased risk between acute myeloid leukemia in adults and the extremely low frequency-electromagnetic to field exposure.

Post-stroke cognitive impairment (PSCI) is a cognitive impairment syndrome that occurs after stroke.The pathogenesis is unknown.Studies have shown that the occurrence and development of PSCI is associated with cerebral small vascular disease (CSVD).The imaging findings mainly include white matter hyperintensities,lacune,cortical or subcortical microinfarction,microbleeds,brain atrophy and enlarged perivascular space.This article reviews the correlation between PSCI and CSCD.

Idiopathic macular hole ( IMH ) refers to full thickness defect of retinal neurepithelium layer in macular area with unclear reasons. Early IMH can be observed. Vitrectomy combined with internal limiting membrane ( ILM ) peeling is a conventional method for treating IMH. The continuous improvement and innovation of ILM surgery contribute greatly to the diversity and maturation of IMH treatment. At present, the pharmacological vitreolysis and pneumatic vitreplysis have gradual progress in the prevention and treatment of IMH. In this article we review the current management of IMH.

Carotid artery stenting has emerged as a therapeutic alternative to carotid artery endarterectomy for stroke prevention in patients with carotid artery stenosis.Preoperative assessment of peri-interventional complications is an important part to make a treatment strategy.However,no such assessment is available in China now.We tried to make a review of the risk models for predicting peri-interventional complications of carotid artery stenting.

Rapid eye movement sleep behavior disorder (RBD) is a condition characterized by rap id eye movement sleep without atonia and with complex behaviors associated with dreams.Numerous studies have revealed that idiopathic RBD is the prodromal manifestation of neurodegenerative disorders,especially those mediated by α-synuclein.The structural and functional imaging of RBD,including transcranial sonog raphy (TCS),MRI,SPECT,PET,are increasingly becoming the hot issues.This review summarizes the radionuclide imaging in RBD,which may be one of the most promising modalities to detect the biomarkers for early diagnosis of neurodegenerative disorders.