Introduction: The previous study confirmed, derivatives of 7-hydroxycoumarin isofraxidin, scopoletin, which is containing in Salsola Laricifolia, are studied to significant effect to cancer cells. The researchers have been determined the natural resources of Salsola Laricifolia grown in Mongolia and worked out of possibility of cultivation of this plant. To investigate of anticancer activity of Salsola Laricifolia and to find out possibility of natural anticancer drug are attracting the researcher’s attention. Methods: The acute toxicity studied by method Prozorovskii V.B. The cancer model is created by urethane, method of Nettleship Kay, Trainin on 50 Wistar strain rats during 4 months. Results: In the oncopathololgical analysis shows: in a Testing group observed infiltrated lymphocyte cells, inflammation cell were determined in interstitial tissue. In ‘1st control group observed difference of epithelium cell, increasing size and number of nucleus. Chromatin was agglomerated. Hyperplasia and infiltrated lymphocyte were produced. In ‘1st control group observed difference of epithelium cell and dysplasia, nucleus polymorphism was observed.The result of ELISA test was in 1st group 23.41±1,17 ng/mL, 2nd group 22.572±1.42 ng/mL, 3rd group was 23.984±0.46 ng/mL, 4th group was 24.573±0.07 ng/mL respectively Conclusions: Oncopathological analysis shows that, Salsola laricifolia has anticancer activity.The result of ELISA test was, the concentrate of p53 3,57% in Testing group; 8,15% in ‘1st control group’ decreased than Healthy groups and its confirmed that Salsola laricifolia has anticancer activity Key words: Salsola laricifolia, anticancer activity, cancer, p53, ELISA test