Background: Smoking is significant risk factor for further kidney failure. Haroun et al. found that current smoking was associated with HR of 2.6 for future RRT and having kidney disease listed on the death certificate compared with the former and never smokers [2]. Regarding smoking and kidney pathophysiology, direct vascular effects are probably a major mechanism [3-5]. Smoking is a particularly associated with atherosclerosis. The purpose of this study was to determine the effects of smoking on renal function and arterial stiffness in the CKD patients. Methods: A cross-sectional study was conducted in which adolescents aged 20 to 60 years with CKD total 125 patients with non diabetic CKD (mean age 40.30±10.82) were recruited. CKD was evaluated by the eGFR using the Cockcroft-Gault formula. Cardio-Ankle vascular index (CAVI) was determined as an index of arterial stiffness.Results: Even though there wasn’t an age difference between the smoking and non smoking groups, the renal function (38.1±22.6 vs. 90.5±59.9, p<0.0001) among smokers decreased comparing to the non smokers. The Pearson’s correlation analysis indicated that the smoking index was significantly correlated with the renal function (r=-0.392, p=0.02) and the arterial stiffness (r=0.573, p<0.0001).Conclusion: We found that smoking influenced on renal, it is a significant risk factor of CKD.

Determining effect of pharmaceutical preparation of Osteocalcium-5 for 50-65years old patients who diagnosed as primary osteoprosis after menopause. All 120 volunteers were divided randomly into control and clinical experiemental group also private specialty test was taken from each group as well. Control group (n60) had oral medication Citratcalcium D, clinical experiement group had oral Osteocalcium-5. After medication result of mineral density of osteoprosis , fracture risk and result of private specialty were compared. Result: 65.8% of patients who diagnosed as primary osteoprosis after menopause are concept of Badgan private specialty. After 2 months of oral medication in each group SOS measurement enhanced by 3-4%, fracture risk decreased by 39.6%. Conclution: In Traditional medical, concept of Badgan private specialty more tendency for osteoprosis. Osteocalcium-5 improves osteon of compact bone patiets with osteoprosis after menopause and decreased risk of fracture. Also result of pharmaceutical preparation of Osteocalcium -5 does not depend on private specialty but patients who are active lifestyle and stomach fire is proper had possitive effect.