"Helicobacter pylori (H.pylori) is considered an etiologic factor for the development of peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The combination of a proton pump inhibitor and two antibiotics has been the recommended first line therapy since the first guidelines for Helicobacter pylori infection in patients were published. However, bacterial resistance and adverse events occurrence are among most frequent causes for anti H.pylori treatment failure. More effective anti H.pylori therapy have been investigated in depth by researchers. One of the potential therapies is probiotic cultures; promising results have been observed in initial studies with numerous probiotic strains. Most of studies showed an improvement of H.pylori gastritis and decreasein H.pylori colonization after administration of probiotics. However, utilization of probiotics alone is not able to complete eradication H.pylori infection as published. The combination of some probiotic strains with standard triple therapy can reduce the occurrence of side effect due to antibiotics and increase the H.pylori eradication rate. In this article, we reviewed the possible mechanisms of action of probiotics on H.pylori and results of published studies using probiotics as possible agents to eradicate"